PMID- 3676759
OWN - NLM
STAT- MEDLINE
DCOM- 19871222
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 420
IP  - 2
DP  - 1987 Sep 15
TI  - Synaptic reorganization in the medial amygdaloid nucleus after lesion of the 
      accessory olfactory bulb of adult rat. I. Quantitative and electron microscopic 
      study of the recovery of synaptic density.
PG  - 243-52
AB  - The time course of the appearance of degenerating synapses and the loss and 
      reappearance of intact synapses was investigated in the medial amygdaloid nucleus 
      (MAN) following lesions of the accessory olfactory bulb (AOB). Degenerating 
      synapses were concentrated in the molecular layer of MAN. A quantitative electron 
      microscopic analysis of the molecular layer was performed at 2, 4, 8, 16, 32 and 
      64 days after the placement of kainic acid injections within AOB. At each 
      survival time, counts of synapses were made from photomicrographic montages. The 
      degenerating synapses were observed at 2 days after lesion. Their density reached 
      a peak at 2 or 4 days after the lesion and decreased thereafter. No degenerating 
      synapses were found at 64 days following the lesion. Shrinkage of the thickness 
      of molecular layer was observed following the AOB lesion. This was most 
      pronounced at 4 or 8 days after the lesion at which time the thickness was 70-75% 
      of the contralateral molecular layer. The shrinkage receded moderately (85% of 
      contralateral layer at 64 days after lesion). The compensated synaptic density of 
      intact synapses was reduced to less than half of the control density at 4 or 8 
      days after the lesion. Thereafter synaptic density increased gradually and 
      reached more than 80% of control density at 64 days after lesion. The recovery in 
      number of intact synapses following the lesion suggests the possibility of 
      synaptic reorganization by remaining afferent fibers.
FAU - Ichikawa, M
AU  - Ichikawa M
AD  - Department of Anatomy and Embryology, Tokyo Metropolitan Institute for 
      Neurosciences, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - EC 1.11.1.- (Horseradish Peroxidase)
SB  - IM
MH  - Amygdala/*physiology/ultrastructure
MH  - Animals
MH  - Cell Count
MH  - Horseradish Peroxidase
MH  - Male
MH  - Microscopy, Electron
MH  - Nerve Degeneration
MH  - *Neuronal Plasticity
MH  - Olfactory Bulb/*physiology/ultrastructure
MH  - Rats
MH  - Synapses/*physiology/ultrastructure
MH  - Time Factors
EDAT- 1987/09/15 00:00
MHDA- 1987/09/15 00:01
CRDT- 1987/09/15 00:00
PHST- 1987/09/15 00:00 [pubmed]
PHST- 1987/09/15 00:01 [medline]
PHST- 1987/09/15 00:00 [entrez]
AID - 0006-8993(87)91244-3 [pii]
AID - 10.1016/0006-8993(87)91244-3 [doi]
PST - ppublish
SO  - Brain Res. 1987 Sep 15;420(2):243-52. doi: 10.1016/0006-8993(87)91244-3.