PMID- 36769304
OWN - NLM
STAT- MEDLINE
DCOM- 20230214
LR  - 20230214
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 3
DP  - 2023 Feb 3
TI  - The Functional Meaning of 5'UTR in Protein-Coding Genes.
LID - 10.3390/ijms24032976 [doi]
LID - 2976
AB  - As it is well known, messenger RNA has many regulatory regions along its sequence 
      length. One of them is the 5' untranslated region (5'UTR), which itself contains 
      many regulatory elements such as upstream ORFs (uORFs), internal ribosome entry 
      sites (IRESs), microRNA binding sites, and structural components involved in the 
      regulation of mRNA stability, pre-mRNA splicing, and translation initiation. 
      Activation of the alternative, more upstream transcription start site leads to an 
      extension of 5'UTR. One of the consequences of 5'UTRs extension may be 
      head-to-head gene overlap. This review describes elements in 5'UTR of 
      protein-coding transcripts and the functional significance of protein-coding 
      genes 5' overlap with implications for transcription, translation, and disease.
FAU - Ryczek, Natalia
AU  - Ryczek N
AUID- ORCID: 0000-0001-5624-079X
AD  - Institute of Human Biology and Evolution, Adam Mickiewicz University in Poznan, 
      Uniwersytetu Ponanskiego 6, 61-614 Poznan, Poland.
FAU - Lys, Aneta
AU  - Lys A
AD  - Institute of Human Biology and Evolution, Adam Mickiewicz University in Poznan, 
      Uniwersytetu Ponanskiego 6, 61-614 Poznan, Poland.
FAU - Makalowska, Izabela
AU  - Makalowska I
AD  - Institute of Human Biology and Evolution, Adam Mickiewicz University in Poznan, 
      Uniwersytetu Ponanskiego 6, 61-614 Poznan, Poland.
LA  - eng
GR  - 2017/25/B/NZ2/01519/National Science Center/
PT  - Journal Article
PT  - Review
DEP - 20230203
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (5' Untranslated Regions)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - 5' Untranslated Regions
MH  - *Protein Biosynthesis
MH  - RNA, Messenger/genetics
MH  - *Gene Expression Regulation
MH  - Regulatory Sequences, Nucleic Acid
PMC - PMC9917990
OTO - NOTNLM
OT  - 5'UTR
OT  - head-to-head genes overlap
OT  - miRNA
OT  - protein-coding genes
OT  - uORF
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/12 06:00
MHDA- 2023/02/15 06:00
PMCR- 2023/02/03
CRDT- 2023/02/11 01:25
PHST- 2022/12/28 00:00 [received]
PHST- 2023/01/20 00:00 [revised]
PHST- 2023/01/26 00:00 [accepted]
PHST- 2023/02/11 01:25 [entrez]
PHST- 2023/02/12 06:00 [pubmed]
PHST- 2023/02/15 06:00 [medline]
PHST- 2023/02/03 00:00 [pmc-release]
AID - ijms24032976 [pii]
AID - ijms-24-02976 [pii]
AID - 10.3390/ijms24032976 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Feb 3;24(3):2976. doi: 10.3390/ijms24032976.