PMID- 36771259 OWN - NLM STAT- MEDLINE DCOM- 20230214 LR - 20230214 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 15 IP - 3 DP - 2023 Jan 20 TI - Joint Effect of Multiple Metals on Hyperuricemia and Their Interaction with Obesity: A Community-Based Cross-Sectional Study in China. LID - 10.3390/nu15030552 [doi] LID - 552 AB - Metal exposures have been inconsistently related to the risk of hyperuricemia, and limited research has investigated the interaction between obesity and metals in hyperuricemia. To explore their associations and interaction effects, 3300 participants were enrolled from 11 districts within 1 province in China, and the blood concentrations of 13 metals were measured to assess internal exposure. Multivariable logistic regression, restricted cubic spline (RCS), Bayesian kernel machine regression (BKMR), and interaction analysis were applied in the single- and multi-metal models. In single-metal models, five metals (V, Cr, Mn, Co, and Zn) were positively associated with hyperuricemia in males, but V was negatively associated with hyperuricemia in females. Following the multi-metal logistic regression, the multivariate-adjusted odds ratios (95% confidence intervals) of hyperuricemia were 1.7 (1.18, 2.45) for Cr and 1.76 (1.26, 2.46) for Co in males, and 0.68 (0.47, 0.99) for V in females. For V and Co, RCS models revealed wavy and inverted V-shaped negative associations with female hyperuricemia risk. The BKMR models showed a significant joint effect of multiple metals on hyperuricemia when the concentrations of five metals were at or above their 55th percentile compared to their median values, and V, Cr, Mn, and Co were major contributors to the combined effect. A potential interaction between Cr and obesity and Zn and obesity in increasing the risk of hyperuricemia was observed. Our results suggest that higher levels of Cr and Co may increase male hyperuricemia risk, while higher levels of V may decrease female hyperuricemia risk. Therefore, the management of metal exposure in the environment and diet should be improved to prevent hyperuricemia. FAU - Wu, Shan AU - Wu S AD - Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China. FAU - Huang, Huimin AU - Huang H AD - Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China. FAU - Ji, Guiyuan AU - Ji G AD - Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. FAU - Li, Lvrong AU - Li L AD - Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China. FAU - Xing, Xiaohui AU - Xing X AD - Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China. FAU - Dong, Ming AU - Dong M AD - Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510399, China. FAU - Ma, Anping AU - Ma A AD - Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510399, China. FAU - Li, Jiajie AU - Li J AD - Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China. FAU - Wei, Yuan AU - Wei Y AD - Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China. FAU - Zhao, Dongwei AU - Zhao D AD - Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China. FAU - Ma, Wenjun AU - Ma W AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510630, China. FAU - Bai, Yan AU - Bai Y AD - Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China. AD - Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. FAU - Wu, Banghua AU - Wu B AD - Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510399, China. FAU - Liu, Tao AU - Liu T AUID- ORCID: 0000-0003-1451-5251 AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510630, China. AD - Disease Control and Prevention Institute of Jinan University, Jinan University, Guangzhou 510632, China. FAU - Chen, Qingsong AU - Chen Q AD - Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China. AD - NMPA Key Laboratory for Technology Research and Evaluation of Pharmacovigilance, Guangdong Pharmaceutical University, 283 Jianghai Avenue, Guangzhou 510300, China. LA - eng GR - 2019GCZX012/the Project for Innovation and Strong School of Department of Education of Guangdong Province/ GR - 2020KCXTD022/National Science Foundation of Guangdong Province Colleges and Universities/ GR - 2019A1515110656/GuangDong Basic and Applied Basic Research Foundation/ PT - Journal Article DEP - 20230120 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Metals) SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - Bayes Theorem MH - *Hyperuricemia/epidemiology MH - Metals MH - China/epidemiology MH - Obesity/epidemiology PMC - PMC9921062 OTO - NOTNLM OT - BKMR models OT - cross-sectional study OT - hyperuricemia OT - interaction OT - obesity OT - whole blood metals COIS- The authors declare no conflict of interest. EDAT- 2023/02/12 06:00 MHDA- 2023/02/15 06:00 PMCR- 2023/01/20 CRDT- 2023/02/11 01:37 PHST- 2022/11/26 00:00 [received] PHST- 2023/01/14 00:00 [revised] PHST- 2023/01/19 00:00 [accepted] PHST- 2023/02/11 01:37 [entrez] PHST- 2023/02/12 06:00 [pubmed] PHST- 2023/02/15 06:00 [medline] PHST- 2023/01/20 00:00 [pmc-release] AID - nu15030552 [pii] AID - nutrients-15-00552 [pii] AID - 10.3390/nu15030552 [doi] PST - epublish SO - Nutrients. 2023 Jan 20;15(3):552. doi: 10.3390/nu15030552.