PMID- 36773884
OWN - NLM
STAT- MEDLINE
DCOM- 20230320
LR  - 20230326
IS  - 1878-7568 (Electronic)
IS  - 1742-7061 (Linking)
VI  - 160
DP  - 2023 Apr 1
TI  - Targeted therapy for peri-prosthetic osteolysis using macrophage 
      membrane-encapsulated human urine-derived stem cell extracellular vesicles.
PG  - 297-310
LID - S1742-7061(23)00074-0 [pii]
LID - 10.1016/j.actbio.2023.02.003 [doi]
AB  - Aseptic loosening of the prosthesis is a severe complication after joint 
      replacement. It is of great practical significance and social value to discover 
      the prevention and treatment strategies for this condition. Exosomes from 
      urine-derived stem cells (Exos) have great potential in promoting bone repair, 
      reconstruction, and regulating bone metabolism. However, they are easily 
      eliminated by macrophages and incapable of targeting the osteolysis zone. In this 
      study, based on macrophage "homing" into periprosthetic osteolysis region and 
      cell membrane encapsulating nanotechnology, exosomes from urine-derived stem 
      cells were encapsulated with macrophage membrane (MM) to prevent periprosthetic 
      osteolysis. We found that macrophage membrane encapsulated urine-derived stem 
      cell-derived exosomes (MM-Exos) can be targeted delivery to the osteolysis zone 
      and enhance the therapeutic effectiveness of Exos, which alleviated wear 
      particles-induced calvarial osteolysis. Furthermore, MM-Exos could provide 
      immunological camouflage and allow the Exos to avoid phagocytosis by macrophages 
      and stimulate cellular uptake by bone marrow-derived stem cells (BMSCs). 
      Therefore, we demonstrated the unique ability of the macrophage membrane as a 
      targeted transport of exosomes from urine-derived stem cells for the prevention 
      and treatment of periprosthetic osteolysis. These biomimetic nanoparticles 
      provided a new therapeutic exosome delivery system for preventing wear 
      particles-induced osteolysis. STATEMENT OF SIGNIFICANCE: Macrophage membrane 
      encapsulated urine-derived stem cell-derived exosomes (MM-Exos) can be targeted 
      delivery to the osteolysis zone and enhance the therapeutic effect of Exos on 
      peri‑prosthetic osteolysis prevention. MM-Exos could allow the Exos to avoid 
      phagocytosis by macrophages and promote the uptake of Exos by BMSCs.
CI  - Copyright (c) 2023 Acta Materialia Inc. Published by Elsevier Ltd. All rights 
      reserved.
FAU - Xie, Jie
AU  - Xie J
AD  - Department of Orthopedics, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, China.
FAU - Hu, Yihe
AU  - Hu Y
AD  - Department of Orthopedics, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, China; Department of Orthopedics, Xiangya Hospital, Central 
      South University, China.
FAU - Li, Hui
AU  - Li H
AD  - Department of Orthopedics, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, China.
FAU - Wang, Yinan
AU  - Wang Y
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, China.
FAU - Fan, Xiaolei
AU  - Fan X
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, China.
FAU - Lu, Wei
AU  - Lu W
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, China.
FAU - Liao, Runzhi
AU  - Liao R
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, China.
FAU - Wang, Haoyi
AU  - Wang H
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, China.
FAU - Cheng, Yurui
AU  - Cheng Y
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, China.
FAU - Yang, Yute
AU  - Yang Y
AD  - Department of Orthopedics, The First Affiliated Hospital, Zhejiang University 
      School of Medicine, China.
FAU - Wang, Jiahao
AU  - Wang J
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, China.
FAU - Liang, Shuailong
AU  - Liang S
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, China.
FAU - Ma, Tianliang
AU  - Ma T
AD  - Department of Orthopedics, Xiangya Hospital, Central South University, China. 
      Electronic address: tianliangma@163.com.
FAU - Su, Weiping
AU  - Su W
AD  - Department of Orthopedics, The 3rd Xiangya Hospital, Central South University, 
      Changsha, China. Electronic address: weiping_1017@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230210
PL  - England
TA  - Acta Biomater
JT  - Acta biomaterialia
JID - 101233144
SB  - IM
MH  - Humans
MH  - *Osteolysis/chemically induced
MH  - Stem Cells
MH  - *Exosomes/metabolism
MH  - Cell Membrane
MH  - Macrophages
OTO - NOTNLM
OT  - Aseptic loosening
OT  - Exosomes
OT  - Macrophage membrane
OT  - Osteolysis
OT  - Urine-derived stem cells
COIS- Declaration of Competing Interest All other authors declare no competing 
      interests.
EDAT- 2023/02/12 06:00
MHDA- 2023/03/21 06:00
CRDT- 2023/02/11 19:28
PHST- 2022/09/19 00:00 [received]
PHST- 2023/02/02 00:00 [revised]
PHST- 2023/02/02 00:00 [accepted]
PHST- 2023/02/12 06:00 [pubmed]
PHST- 2023/03/21 06:00 [medline]
PHST- 2023/02/11 19:28 [entrez]
AID - S1742-7061(23)00074-0 [pii]
AID - 10.1016/j.actbio.2023.02.003 [doi]
PST - ppublish
SO  - Acta Biomater. 2023 Apr 1;160:297-310. doi: 10.1016/j.actbio.2023.02.003. Epub 
      2023 Feb 10.