PMID- 36775655
OWN - NLM
STAT- MEDLINE
DCOM- 20230214
LR  - 20230227
IS  - 1464-5157 (Electronic)
IS  - 0265-6736 (Linking)
VI  - 40
IP  - 1
DP  - 2023
TI  - Adverse events and complications after magnetic resonance-guided focused 
      ultrasound (MRgFUS) therapy in uterine fibroids - a systematic review and future 
      perspectives.
PG  - 2174274
LID - 10.1080/02656736.2023.2174274 [doi]
AB  - OBJECTIVES: The aim of this review was to analyze and summarize the most common 
      adverse events (AEs) and complications after magnetic resonance-guided focused 
      ultrasound (MRgFUS) therapy in uterine fibroids (UFs) and to establish the risk 
      factors of their occurrence. METHODS: We searched for original research studies 
      evaluating MRgFUS therapy in UFs with outcomes containing AEs and/or 
      complications in different databases (PubMed/MEDLINE, SCOPUS, COCHRANE) until 
      March 2022. Reviews, editorials, opinions or letters, case studies, conference 
      papers and abstracts were excluded from the analysis. The systematic literature 
      search identified 446 articles, 43 of which were analyzed. RESULTS: According to 
      available evidence, the overall incidence of serious complications in MRgFUS 
      therapy is relatively low. No AEs/complications were reported in 11 out of 43 
      analyzed studies. The mean occurrence of all AEs in the analyzed material was 
      24.67%. The most commonly described AEs included pain, skin burns, urinary tract 
      infections and sciatic neuropraxia. Major AEs, such as skin ulcerations or deep 
      vein thrombosis, occurred in 0.41% of cases in the analyzed material. CONCLUSION: 
      MRgFUS seems to be safe in UF therapy. The occurrence of AEs, especially major 
      ones, is relatively low in comparison with other methods. The new devices and 
      more experience of their users seem to reduce AE rate. The lack of unification in 
      AE reporting and missing data are the main issues in this area. More prospective, 
      randomized studies with unified reporting and long follow-up are needed to 
      determine the safety in a long-term perspective.
FAU - Kociuba, Jakub
AU  - Kociuba J
AUID- ORCID: 0000-0001-7959-3707
AD  - Second Department of Obstetrics and Gynecology, Center of Postgraduate Medical 
      Education, Warsaw, Poland.
FAU - Lozinski, Tomasz
AU  - Lozinski T
AUID- ORCID: 0000-0002-5129-5262
AD  - Department of Obstetrics and Gynecology, Pro-Familia Hospital, Rzeszow, Poland.
AD  - Department of Gynecology and Obstetrics, Institute of Medical Sciences, Medical 
      College of Rzeszow University, Rzeszow, Poland.
FAU - Zgliczynska, Magdalena
AU  - Zgliczynska M
AUID- ORCID: 0000-0003-4957-4921
AD  - Department of Obstetrics, Perinatology and Neonatology, Centre of Postgraduate 
      Medical Education, Warsaw, Poland.
FAU - Byrczak, Maciej
AU  - Byrczak M
AUID- ORCID: 0000-0002-8476-8759
AD  - Second Department of Obstetrics and Gynecology, Center of Postgraduate Medical 
      Education, Warsaw, Poland.
FAU - Vitale, Salvatore Giovanni
AU  - Vitale SG
AUID- ORCID: 0000-0001-6871-6097
AD  - Obstetrics and Gynecology Unit, Department of General Surgery and Medical 
      Surgical Specialties, University of Catania, Italy.
FAU - Skrzypczak, Maciej
AU  - Skrzypczak M
AUID- ORCID: 0000-0002-1289-5900
AD  - Second Department of Gynecology, Medical University of Lublin, Lublin, Poland.
FAU - Zareba, Kornelia
AU  - Zareba K
AUID- ORCID: 0000-0002-8262-4380
AD  - Obstetrics and Gynecology Department, College of Medicine and Health Sciences, 
      United Arab Emirates University, Al Ain, United Arab Emirates.
FAU - Ciebiera, Michal
AU  - Ciebiera M
AUID- ORCID: 0000-0001-5780-5983
AD  - Second Department of Obstetrics and Gynecology, Center of Postgraduate Medical 
      Education, Warsaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
PL  - England
TA  - Int J Hyperthermia
JT  - International journal of hyperthermia : the official journal of European Society 
      for Hyperthermic Oncology, North American Hyperthermia Group
JID - 8508395
SB  - IM
MH  - Humans
MH  - Female
MH  - Prospective Studies
MH  - Treatment Outcome
MH  - *Magnetic Resonance Imaging, Interventional/methods
MH  - *Leiomyoma/diagnostic imaging/therapy
MH  - *High-Intensity Focused Ultrasound Ablation/adverse effects/methods
MH  - Magnetic Resonance Imaging/methods
MH  - Magnetic Resonance Spectroscopy
MH  - *Uterine Neoplasms
OTO - NOTNLM
OT  - MR-HIFU
OT  - Magnetic resonance-guided focused ultrasound
OT  - adverse event
OT  - complication
OT  - uterine fibroid
EDAT- 2023/02/13 06:00
MHDA- 2023/02/15 06:00
CRDT- 2023/02/12 21:32
PHST- 2023/02/12 21:32 [entrez]
PHST- 2023/02/13 06:00 [pubmed]
PHST- 2023/02/15 06:00 [medline]
AID - 10.1080/02656736.2023.2174274 [doi]
PST - ppublish
SO  - Int J Hyperthermia. 2023;40(1):2174274. doi: 10.1080/02656736.2023.2174274.