PMID- 36775854
OWN - NLM
STAT- MEDLINE
DCOM- 20230329
LR  - 20240109
IS  - 1738-8872 (Electronic)
IS  - 1017-7825 (Print)
IS  - 1017-7825 (Linking)
VI  - 33
IP  - 3
DP  - 2023 Mar 28
TI  - Anti-Atopic Activities of Sargassum horneri Hot Water Extracts in 
      2,4-Dinitrochlorobezene-Induced Mouse Models.
PG  - 363-370
LID - 10.4014/jmb.2211.11007 [doi]
AB  - Atopic dermatitis (AD) is a chronic inflammation associated with skin 
      hypersensitivity caused by environmental factors. The objent of this study was to 
      assess the hot water extracts of Sargassum horneri (SHHWE) on AD. AD was induced 
      by spreading 2,4-dinitrochlorobenzene (DNCB) on the BALB/c mice. The efficacy of 
      SHHWE was tested by observing the immunoglobulin E (IgE), cytokine, skin clinical 
      severity score and cytokine secretions in concanavalin A (Con A)-stimulated 
      splenocytes. The levels of interleukine (IL)-4, IL-5 and IgE, the 
      pro-inflammatory cytokines that are closely related, were notably suppressed in a 
      does-dependent manner by SHHWE, whereas the level of interferon gamma (IFN-gamma), the 
      atopy-related Th1 cytokine inhibiting the production of Th2 cytokines, was 
      increased. Therefore, these results show that SHHWE has a potent anti-inhibitory 
      effect on AD and is highly valuable for cosmetic development.
FAU - Woo, Ga-Eun
AU  - Woo GE
AD  - Department of Food Science and Technology/Institute of Food Science, Pukyong 
      National University, Busan 48513, Republic of Korea.
FAU - Hwang, Hye-Ji
AU  - Hwang HJ
AD  - Department of Food Science and Technology/Institute of Food Science, Pukyong 
      National University, Busan 48513, Republic of Korea.
FAU - Park, A-Yeoung
AU  - Park AY
AD  - Department of Food Science and Technology/Institute of Food Science, Pukyong 
      National University, Busan 48513, Republic of Korea.
FAU - Sim, Ji-Yoon
AU  - Sim JY
AD  - Department of Food Science and Technology/Institute of Food Science, Pukyong 
      National University, Busan 48513, Republic of Korea.
FAU - Woo, Seon-Young
AU  - Woo SY
AD  - Department of Food Science and Technology/Institute of Food Science, Pukyong 
      National University, Busan 48513, Republic of Korea.
FAU - Kim, Min-Ji
AU  - Kim MJ
AD  - Department of Food Science and Technology/Institute of Food Science, Pukyong 
      National University, Busan 48513, Republic of Korea.
FAU - Jeong, So-Mi
AU  - Jeong SM
AD  - Institute of Fisheries Sciences, Pukyong National University, Busan 48513, 
      Republic of Korea.
FAU - Sung, Nak-Yun
AU  - Sung NY
AD  - Division of Natural Product Research, Korea Prime Pharmacy CO., LTD., Jeonnam 
      58144, Korea.
FAU - Kim, Dong-Sub
AU  - Kim DS
AD  - Division of Natural Product Research, Korea Prime Pharmacy CO., LTD., Jeonnam 
      58144, Korea.
FAU - Ahn, Dong-Hyun
AU  - Ahn DH
AD  - Department of Food Science and Technology/Institute of Food Science, Pukyong 
      National University, Busan 48513, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20230113
PL  - Korea (South)
TA  - J Microbiol Biotechnol
JT  - Journal of microbiology and biotechnology
JID - 9431852
RN  - 0 (Plant Extracts)
RN  - 0 (Cytokines)
RN  - 059QF0KO0R (Water)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Mice
MH  - *Sargassum
MH  - Plant Extracts/pharmacology
MH  - Skin
MH  - *Dermatitis, Atopic/chemically induced
MH  - Cytokines
MH  - Water
MH  - Immunoglobulin E
MH  - Mice, Inbred BALB C
PMC - PMC10084757
OTO - NOTNLM
OT  - IgE
OT  - Sargassum horneri
OT  - Th1
OT  - Th2
OT  - atopic dermatitis
OT  - skin severity score
COIS- Conflict of Interest The authors have no financial conflicts of interest to 
      declare.
EDAT- 2023/02/13 06:00
MHDA- 2023/03/29 06:04
PMCR- 2023/01/13
CRDT- 2023/02/12 23:52
PHST- 2022/11/04 00:00 [received]
PHST- 2022/12/06 00:00 [revised]
PHST- 2022/12/18 00:00 [accepted]
PHST- 2023/03/29 06:04 [medline]
PHST- 2023/02/13 06:00 [pubmed]
PHST- 2023/02/12 23:52 [entrez]
PHST- 2023/01/13 00:00 [pmc-release]
AID - jmb.2211.11007 [pii]
AID - jmb-33-3-363 [pii]
AID - 10.4014/jmb.2211.11007 [doi]
PST - ppublish
SO  - J Microbiol Biotechnol. 2023 Mar 28;33(3):363-370. doi: 10.4014/jmb.2211.11007. 
      Epub 2023 Jan 13.