PMID- 36776430
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230214
IS  - 2667-193X (Electronic)
IS  - 2667-193X (Linking)
VI  - 12
DP  - 2022 Aug
TI  - Validating intrinsic capacity to measure healthy aging in an upper middle-income 
      country: Findings from the ELSI-Brazil.
PG  - 100284
LID - 10.1016/j.lana.2022.100284 [doi]
LID - 100284
AB  - BACKGROUND: While efforts have been made to validate intrinsic capacity (IC) as a 
      multidimensional indicator of healthy aging in high-income countries, we still 
      need evidence from lower-income countries. We examined associations of IC with 
      wide ranges of activities of daily living in a nationally representative sample 
      of Brazilians aged>/=50 years. METHODS: This cross-sectional analysis included 7175 
      participants from the Brazilian Longitudinal Study of Aging. IC domains 
      (cognitive, psychological, sensory, locomotor, and vitality) were determined 
      using self-reported and physical performance measures. IC was operationalized 
      through factorial analysis. We investigated associations of IC and its domains 
      with functional ability in basic, instrumental, and advanced activities of daily 
      living (ADL, IADL, and AADL) using logistic regressions adjusted for 
      sociodemographic, clinical, and modifiable risk factors. FINDINGS: The IC 
      bi-factorial model revealed satisfactory goodness-of-fit. Preserved ability in 
      ADL and IADL, respectively, ranged from 69% and 29% to 89% and 74% across IC 
      quartiles. In adjusted analyses, every standard deviation increment in IC 
      composite score was associated with almost twice the odds of preserved ADL 
      (OR=1.72; 95%CI=1.54-1.93), preserved IADL (OR=1.95; 95%CI=1.77-2.16), and high 
      performance in AADL (OR=1.79; 95%CI=1.59-2.00). Similar results were reported 
      using the IC domains as predictors. Although age, race/ethnicity, and education 
      did not modify associations of IC with functional ability, we found sex 
      differences with stronger relationships of IC with preserved ADL or IADL in 
      females. INTERPRETATION: Our results support IC validity and reliability to 
      measure healthy aging in diverse socioeconomic and cultural settings. 
      Incorporating IC in routine practices can promote holistic and person-centered 
      care approaches in aging societies. FUNDING: The Brazilian Ministry of Health and 
      Ministry of Science, Technology, Innovation, and Communication.
CI  - (c) 2022 The Author(s).
FAU - Aliberti, Marlon J R
AU  - Aliberti MJR
AD  - Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de 
      Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de 
      Sao Paulo, Sao Paulo, Brazil.
AD  - Research Institute, Hospital Sirio-Libanes, Sao Paulo, Brazil.
FAU - Bertola, Laiss
AU  - Bertola L
AD  - Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de 
      Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de 
      Sao Paulo, Sao Paulo, Brazil.
FAU - Szlejf, Claudia
AU  - Szlejf C
AD  - Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de 
      Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de 
      Sao Paulo, Sao Paulo, Brazil.
AD  - Department of Big Data, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
FAU - Oliveira, Deborah
AU  - Oliveira D
AD  - Department of Psychiatry, Escola Paulista de Medicina, Universidade Federal de 
      Sao Paulo, Sao Paulo, Brazil.
FAU - Piovezan, Ronaldo D
AU  - Piovezan RD
AD  - Department of Psychobiology, Universidade Federal de Sao Paulo, Sao Paulo, 
      Brazil.
FAU - Cesari, Matteo
AU  - Cesari M
AD  - Department of Clinical Sciences and Community Health, University of Milan, Milan, 
      Italy.
FAU - de Andrade, Fabiola Bof
AU  - de Andrade FB
AD  - Rene Rachou Institute, Fundacao Oswaldo Cruz, Minas Gerais, Brazil.
FAU - Lima-Costa, Maria Fernanda
AU  - Lima-Costa MF
AD  - Rene Rachou Institute, Fundacao Oswaldo Cruz, Minas Gerais, Brazil.
AD  - Post Graduation in Public Health, Universidade Federal de Minas Gerais, Minas 
      Gerais, Brazil.
FAU - Perracini, Monica Rodrigues
AU  - Perracini MR
AD  - Master's and Doctoral Program in Physical Therapy, Universidade Cidade de Sao 
      Paulo, Sao Paulo, Brazil.
FAU - Ferri, Cleusa P
AU  - Ferri CP
AD  - Department of Psychiatry, Escola Paulista de Medicina, Universidade Federal de 
      Sao Paulo, Sao Paulo, Brazil.
FAU - Suemoto, Claudia K
AU  - Suemoto CK
AD  - Laboratorio de Investigacao Medica em Envelhecimento (LIM-66), Servico de 
      Geriatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de 
      Sao Paulo, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20220527
PL  - England
TA  - Lancet Reg Health Am
JT  - Lancet regional health. Americas
JID - 9918232503006676
PMC - PMC9903598
OTO - NOTNLM
OT  - AADL, Advanced Activities of Daily Living
OT  - ADL, Activities of Daily Living
OT  - Activities of daily living
OT  - CES-D, Center for Epidemiologic Studies Depression Scale
OT  - Developing countries
OT  - ELSI-Brazil, The Brazilian Longitudinal Study of Aging
OT  - Functional status
OT  - Gender diversity
OT  - Geriatric assessment
OT  - Healthy aging
OT  - IADL, Instrumental Activities of Daily Living
OT  - IC, Intrinsic Capacity
OT  - Intrinsic capacity
OT  - LMICs, Low- and Middle-income Countries
COIS- The authors have no competing interests.
EDAT- 2023/02/14 06:00
MHDA- 2023/02/14 06:01
PMCR- 2022/05/27
CRDT- 2023/02/13 03:18
PHST- 2023/02/13 03:18 [entrez]
PHST- 2023/02/14 06:00 [pubmed]
PHST- 2023/02/14 06:01 [medline]
PHST- 2022/05/27 00:00 [pmc-release]
AID - S2667-193X(22)00101-6 [pii]
AID - 100284 [pii]
AID - 10.1016/j.lana.2022.100284 [doi]
PST - epublish
SO  - Lancet Reg Health Am. 2022 May 27;12:100284. doi: 10.1016/j.lana.2022.100284. 
      eCollection 2022 Aug.