PMID- 36776564
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230214
IS  - 2753-149X (Electronic)
IS  - 2753-149X (Linking)
VI  - 1
DP  - 2022
TI  - Adolescent fluoxetine exposure increases ERK-related signaling within the 
      prefrontal cortex of adult male Sprague-Dawley rats.
LID - kvac015 [pii]
LID - 10.1093/oons/kvac015 [doi]
AB  - There has been a disproportionate increase in fluoxetine (FLX) prescription rates 
      within the juvenile population. Thus, we evaluated how adolescent FLX exposure 
      alters expression/phosphorylation of proteins from the extracellular signal 
      regulated kinase (ERK)-1/2 cascade within the adult prefrontal cortex (PFC). Male 
      Sprague-Dawley rats were exposed to FLX (20 mg/kg) for 15 consecutive days 
      (postnatal-day [PD] 35-49). At PD70 (adulthood), we examined protein markers for 
      ERK1/2, ribosomal S6 kinase (RSK), and mammalian target of rapamycin (mTOR). 
      FLX-pretreatment decreased body weight, while increasing PFC phosphorylation of 
      ERK1/2 and RSK, as well as total mTOR protein expression in adulthood. We provide 
      first-line evidence that juvenile FLX-pretreatment induces long-term decreases in 
      body weight-gain, along with neurobiological changes in the adult PFC - 
      highlighting that early-life antidepressant exposure increases ERK-related 
      signaling markers in later life.
FAU - Themann, Anapaula
AU  - Themann A
AD  - Department of Psychology, The University of Texas at El Paso, El Paso, TX, USA.
FAU - Rodriguez, Minerva
AU  - Rodriguez M
AD  - Department of Psychology, The University of Texas at El Paso, El Paso, TX, USA.
FAU - Garcia-Carachure, Israel
AU  - Garcia-Carachure I
AD  - Department of Psychology, The University of Texas at El Paso, El Paso, TX, USA.
FAU - Lira, Omar
AU  - Lira O
AD  - Department of Psychology, The University of Texas at El Paso, El Paso, TX, USA.
FAU - Iniguez, Sergio D
AU  - Iniguez SD
AD  - Department of Psychology, The University of Texas at El Paso, El Paso, TX, USA.
LA  - eng
GR  - SC2 GM109811/GM/NIGMS NIH HHS/United States
GR  - SC3 GM130467/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20221020
PL  - England
TA  - Oxf Open Neurosci
JT  - Oxford open neuroscience
JID - 9918487584406676
PMC - PMC9918101
MID - NIHMS1844978
OTO - NOTNLM
OT  - Antidepressant
OT  - ERK
OT  - Long-term
OT  - MAPK
OT  - RSK
OT  - mTOR
COIS- Conflict of Interest The authors declare no financial or non-financial conflicts 
      of interest. The funding agency was not involved in the experimental design, data 
      collection process, interpretation of results, nor writing of the manuscript for 
      publication.
EDAT- 2023/02/14 06:00
MHDA- 2023/02/14 06:01
PMCR- 2022/10/20
CRDT- 2023/02/13 03:21
PHST- 2023/02/13 03:21 [entrez]
PHST- 2023/02/14 06:00 [pubmed]
PHST- 2023/02/14 06:01 [medline]
PHST- 2022/10/20 00:00 [pmc-release]
AID - kvac015 [pii]
AID - 10.1093/oons/kvac015 [doi]
PST - ppublish
SO  - Oxf Open Neurosci. 2022;1:kvac015. doi: 10.1093/oons/kvac015. Epub 2022 Oct 20.