PMID- 36777048
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230328
IS  - 2631-827X (Electronic)
IS  - 2631-827X (Linking)
VI  - 4
IP  - 2
DP  - 2022 Apr
TI  - Case Series: Re-induction of Intravenous, Weight-Based Ustekinumab Is Well 
      Tolerated in Patients With Moderate-Severe Crohn's Disease.
PG  - otac012
LID - 10.1093/crocol/otac012 [doi]
LID - otac012
AB  - BACKGROUND: Crohn's disease (CD) patients may benefit from biologic optimization. 
      METHODS: We retrospectively assessed adverse events (AEs) and clinical/endoscopic 
      response after ustekinumab re-induction in CD patients. RESULTS: We identified 28 
      patients, all with prior biologic exposure. Eight weeks following re-induction, 
      10.7% reported >/=1 AE. Three serious AEs occurred in a single patient (CD flares). 
      No infusion reactions occurred. 53.8% and 38.5% achieved clinical response and 
      remission, respectively. 42.8% achieved both endoscopic improvement and 
      remission. CONCLUSIONS: Ustekinumab re-induction was well tolerated. Clinical and 
      endoscopic disease activity improved in some patients. Further larger studies are 
      needed to verify these findings in a broader population.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of Crohn's & 
      Colitis Foundation.
FAU - Lee, Scott David
AU  - Lee SD
AUID- ORCID: 0000-0001-8936-8052
AD  - University of Washington, Division of Gastroenterology, Seattle, Washington, USA.
FAU - Kamp, Kendra
AU  - Kamp K
AD  - University of Washington, Division of Gastroenterology, Seattle, Washington, USA.
FAU - Clark-Snustad, Kindra Dawn
AU  - Clark-Snustad KD
AD  - University of Washington, Division of Gastroenterology, Seattle, Washington, USA.
LA  - eng
PT  - Journal Article
DEP - 20220427
PL  - England
TA  - Crohns Colitis 360
JT  - Crohn's & colitis 360
JID - 101752188
PMC - PMC9802251
OTO - NOTNLM
OT  - Crohn's disease
OT  - re-induction
OT  - ustekinumab
EDAT- 2023/02/14 06:00
MHDA- 2023/02/14 06:01
PMCR- 2022/04/27
CRDT- 2023/02/13 03:29
PHST- 2022/02/03 00:00 [received]
PHST- 2023/02/13 03:29 [entrez]
PHST- 2023/02/14 06:00 [pubmed]
PHST- 2023/02/14 06:01 [medline]
PHST- 2022/04/27 00:00 [pmc-release]
AID - otac012 [pii]
AID - 10.1093/crocol/otac012 [doi]
PST - epublish
SO  - Crohns Colitis 360. 2022 Apr 27;4(2):otac012. doi: 10.1093/crocol/otac012. 
      eCollection 2022 Apr.