PMID- 36777353
OWN - NLM
STAT- MEDLINE
DCOM- 20230214
LR  - 20230228
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 14
DP  - 2023
TI  - Association between body fat and sarcopenia in older adults with type 2 diabetes 
      mellitus: A cross-sectional study.
PG  - 1094075
LID - 10.3389/fendo.2023.1094075 [doi]
LID - 1094075
AB  - OBJECTIVES: To investigate the association between body fat (BF%) and sarcopenia 
      in older adults with type 2 diabetes mellitus (T2DM) and potential link with 
      increased levels of inflammatory indicators and insulin resistance. METHODS: A 
      total of 543 older adults with T2DM were included in this cross-sectional study. 
      Appendicular skeletal muscle (ASM), handgrip strength and gait speed were 
      measured to diagnose sarcopenia according to the updated Asian Working Group for 
      Sarcopenia (AWGS) 2019 criteria. Body composition data were tested using 
      dual-energy X-ray absorptiometry (DEXA). Levels of serum high-sensitive 
      C-reactive protein (hs-CRP), interleukin-6, fasting blood insulin (FINS), 
      hemoglobin A1c (HbA1c), 25-hydroxyvitamin D(3) [25(OH) D(3)] were also 
      determined. RESULTS: The prevalence of sarcopenia in all participants was 8.84%, 
      of which 11.90% were male and 5.84% females. The Pearson's correlation analysis 
      revealed that BF% was negatively correlated with gait speed in men and women (R 
      =-0.195, P=0.001; R = -0.136, P =0.025, respectively). After adjusting for all 
      potential confounders, sarcopenia was positive associated with BF% (male, OR: 
      1.38, 95% CI: 1.15-1.65, P< 0.001; female, OR: 1.30, 95% CI: 1.07-1.56, P=0.007), 
      and negatively associated with body mass index (BMI) (male, OR: 0.57, 95% CI: 
      0.44-0.73, P<0.001; female, OR: 0.48, 95% CI: 0.33-0.70, P<0.001). No significant 
      differences were found in hs-CRP, interleukin-6, and insulin resistance between 
      older T2DM adults with and without sarcopenia. CONCLUSION: Higher BF% was linked 
      to an increased risk of sarcopenia in older adults with T2DM, suggesting the 
      importance of assessing BF% rather than BMI alone to manage sarcopenia.
CI  - Copyright (c) 2023 Sun, Fu, Mu, Duan, Chan and Xiu.
FAU - Sun, Lina
AU  - Sun L
AD  - Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital, 
      Capital Medical University, Beijing, China.
FAU - Fu, Junling
AU  - Fu J
AD  - Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital, 
      Capital Medical University, Beijing, China.
FAU - Mu, Zhijing
AU  - Mu Z
AD  - Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital, 
      Capital Medical University, Beijing, China.
FAU - Duan, Xiaoye
AU  - Duan X
AD  - Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital, 
      Capital Medical University, Beijing, China.
FAU - Chan, Piu
AU  - Chan P
AD  - National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, 
      Capital Medical University, Beijing, China.
AD  - Department of Neurobiology, Neurology and Geriatrics, Beijing Institute of 
      Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, China.
AD  - Advanced Innovation Center for Human Brain Protection, Capital Medical 
      University, Beijing, China.
AD  - Key Laboratory for Neurodegenerative Disease of the Ministry of Education, 
      Clinical Center for Parkinson's Disease, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory for Parkinson's Disease, Xuanwu Hospital, Capital Medical 
      University, Beijing, China.
AD  - Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China.
FAU - Xiu, Shuangling
AU  - Xiu S
AD  - Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital, 
      Capital Medical University, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230127
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - Aged
MH  - *Sarcopenia/epidemiology/etiology/diagnosis
MH  - Cross-Sectional Studies
MH  - Hand Strength
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Insulin Resistance
MH  - C-Reactive Protein
MH  - Interleukin-6
MH  - Adipose Tissue
PMC - PMC9911832
OTO - NOTNLM
OT  - China
OT  - body composition
OT  - body fat
OT  - diabetes
OT  - obesity
OT  - sarcopenia
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/02/14 06:00
MHDA- 2023/02/15 06:00
PMCR- 2023/01/01
CRDT- 2023/02/13 03:34
PHST- 2022/11/09 00:00 [received]
PHST- 2023/01/17 00:00 [accepted]
PHST- 2023/02/13 03:34 [entrez]
PHST- 2023/02/14 06:00 [pubmed]
PHST- 2023/02/15 06:00 [medline]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2023.1094075 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2023 Jan 27;14:1094075. doi: 
      10.3389/fendo.2023.1094075. eCollection 2023.