PMID- 36778550
OWN - NLM
STAT- MEDLINE
DCOM- 20230214
LR  - 20230328
IS  - 2296-2565 (Electronic)
IS  - 2296-2565 (Linking)
VI  - 11
DP  - 2023
TI  - Reduced serum 25(OH)D is closely related to bronchial mucus plug formation in 
      children with mycoplasma pneumonia: A prospective cohort study.
PG  - 1099683
LID - 10.3389/fpubh.2023.1099683 [doi]
LID - 1099683
AB  - BACKGROUND: The relationship between vitamin D nutritional status and the 
      formation of bronchial mucus plugs (BMPs) is unclear. The aims of the current 
      study were to investigate associations between serum 25(OH)D levels, serum 
      inflammatory factors, and clinical characteristics in children with mycoplasma 
      pneumonia (MPP), and to summarize the risk factors for BMPs in children with MPP. 
      METHODS: Clinical data from 175 children with MPP were collected and analyzed, 
      the children were divided into a BMP group and a non-BMP group. Serum 25(OH)D 
      levels, IL-8, and various inflammatory factors were compared in the two groups. 
      Associations between 25(OH)D levels and IL-8, various inflammatory factors, and 
      clinical characteristics were analyzed, and the diagnostic value of serum 25(OH)D 
      levels was assessed. RESULTS: Serum 25(OH)D level was significantly lower in the 
      BMP group (p < 0.05). Serum IL-8 level, percentages of neutrophils, and some 
      inflammatory factors were significantly higher in the BMP group (p < 0.05). Serum 
      25(OH)D level was negatively correlated with IL-8, neutrophil percentage, various 
      inflammatory factors (all p < 0.05). It was also associated with lobular 
      infection, pleural effusion, mechanical ventilation, and mycoplasma 2,063/2,064 
      mutation (all p < 0.05). In multivariate regression analysis 25(OH)D [odds ratio 
      (OR) 0.98, 95% confidence interval (CI) 0.97-0.99, p = 0.003], IL-8 (OR 1.02, 95% 
      CI 1.00-1.04, p = 0.002), polylobular infection (OR 1.75, 95% CI 1.17-2.64, p = 
      0.007), and MP DNA copies (OR 0.98, 95% CI 1.04-1.01, p = 0.022) were independent 
      risk factors for BMPs, and the area under the curve value was 0.915 (95% CI 
      0.895-0.935). If the serum 25(OH)D level was <50 nmol/L, the respective 
      percentages for sensitivity, specificity, positive predictive value, and negative 
      predictive value were 97, 81, 78.9, and 97.6%. CONCLUSIONS: Vitamin D deficiency 
      is common in children with MPP, and 25(OH)D levels are closely associated with 
      inflammatory factors and disease severity in children. The serum 25 (OH) D level 
      of MPP children with BMPs was lower than that of children without BMPs. Serum 
      25(OH)D can be used as a marker for the diagnosis of MPP in children with BMPs.
CI  - Copyright (c) 2023 Kun, Silei, Sun and Wenyan.
FAU - Kun, Jiang
AU  - Kun J
AD  - Department of Respiratory Medicine, Shanghai Children's Hospital, School of 
      Medicine, Shanghai Jiao Tong University, Shanghai, China.
FAU - Silei, Yan
AU  - Silei Y
AD  - Department of Respiratory Medicine, Shanghai Children's Hospital, School of 
      Medicine, Shanghai Jiao Tong University, Shanghai, China.
FAU - Sun, Chao
AU  - Sun C
AD  - Department of Respiratory Medicine, Shanghai Children's Hospital, School of 
      Medicine, Shanghai Jiao Tong University, Shanghai, China.
FAU - Wenyan, Huang
AU  - Wenyan H
AD  - Department of Nephrology, Shanghai Children's Hospital, School of Medicine, 
      Shanghai Jiao Tong University, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20230126
PL  - Switzerland
TA  - Front Public Health
JT  - Frontiers in public health
JID - 101616579
RN  - A288AR3C9H (25-hydroxyvitamin D)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Humans
MH  - Child
MH  - *Pneumonia, Mycoplasma/complications/diagnosis
MH  - Mycoplasma pneumoniae
MH  - Prospective Studies
MH  - Interleukin-8
MH  - Mucus
PMC - PMC9909285
OTO - NOTNLM
OT  - 25 hydroxyvitamin D
OT  - Mycoplasma pneumoniae
OT  - children
OT  - mycoplasma pneumonia
OT  - particularly bronchial mucus plugs
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/02/14 06:00
MHDA- 2023/02/15 06:00
PMCR- 2023/01/26
CRDT- 2023/02/13 03:48
PHST- 2022/11/16 00:00 [received]
PHST- 2023/01/09 00:00 [accepted]
PHST- 2023/02/13 03:48 [entrez]
PHST- 2023/02/14 06:00 [pubmed]
PHST- 2023/02/15 06:00 [medline]
PHST- 2023/01/26 00:00 [pmc-release]
AID - 10.3389/fpubh.2023.1099683 [doi]
PST - epublish
SO  - Front Public Health. 2023 Jan 26;11:1099683. doi: 10.3389/fpubh.2023.1099683. 
      eCollection 2023.