PMID- 36780170
OWN - NLM
STAT- MEDLINE
DCOM- 20230328
LR  - 20230406
IS  - 1521-3773 (Electronic)
IS  - 1433-7851 (Linking)
VI  - 62
IP  - 15
DP  - 2023 Apr 3
TI  - Heterostructures with Built-in Electric Fields for Long-lasting Chemodynamic 
      Therapy.
PG  - e202300356
LID - 10.1002/anie.202300356 [doi]
AB  - Sustained signal activation by hydroxyl radicals (⋅OH) has great significance, 
      especially for tumor treatment, but remains challenging. Here, a built-in 
      electric field (BIEF)-driven strategy was proposed for sustainable generation of 
      ⋅OH, thereby achieving long-lasting chemodynamic therapy (LCDT). As a proof of 
      concept, a novel Janus-like Fe@Fe(3) O(4) -Cu(2) O heterogeneous catalyst was 
      designed and synthesized, in which the BIEF induced the transfer of electrons in 
      the Fe core to the surface, reducing  identical withCu(2+) to  identical withCu(+) , thus achieving 
      continuous Fenton-like reactions and ⋅OH release for over 18 h, which is 
      approximately 12 times longer than that of Fe(3) O(4) -Cu(2) O and 72 times 
      longer than that of Cu(2) O nanoparticles. In vitro and in vivo antitumor results 
      indicated that sustained ⋅OH levels led to persistent extracellular regulated 
      protein kinases (ERK) signal activation and irreparable oxidative damage to tumor 
      cells, which promoted irreversible tumor apoptosis. Importantly, this strategy 
      provides ideas for developing long-acting nanoplatforms for various applications.
CI  - (c) 2023 Wiley-VCH GmbH.
FAU - Zhang, Huilin
AU  - Zhang H
AD  - Departments of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan 
      University, Shanghai, 200040, P. R. China.
AD  - Department of Materials Science and State Key Laboratory of Molecular Engineering 
      of Polymers, Fudan University, Shanghai, 200438, P. R. China.
FAU - Chen, Yang
AU  - Chen Y
AD  - School of Life Sciences and Technology, Tongji University, Shanghai, 200092, P. 
      R. China.
FAU - Hua, Wei
AU  - Hua W
AD  - Departments of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan 
      University, Shanghai, 200040, P. R. China.
FAU - Gu, Wenjun
AU  - Gu W
AD  - Department of Materials Science and State Key Laboratory of Molecular Engineering 
      of Polymers, Fudan University, Shanghai, 200438, P. R. China.
FAU - Zhuang, Hongjun
AU  - Zhuang H
AD  - Department of Materials Science and State Key Laboratory of Molecular Engineering 
      of Polymers, Fudan University, Shanghai, 200438, P. R. China.
AD  - Departments of Rehabilitation, Zhongshan Hospital, Fudan University, Shanghai, 
      200032, P. R. China.
FAU - Li, Huiyan
AU  - Li H
AD  - Department of Materials Science and State Key Laboratory of Molecular Engineering 
      of Polymers, Fudan University, Shanghai, 200438, P. R. China.
FAU - Jiang, Xingwu
AU  - Jiang X
AD  - Department of Materials Science and State Key Laboratory of Molecular Engineering 
      of Polymers, Fudan University, Shanghai, 200438, P. R. China.
FAU - Mao, Ying
AU  - Mao Y
AD  - Departments of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan 
      University, Shanghai, 200040, P. R. China.
FAU - Liu, Yanyan
AU  - Liu Y
AD  - Department of Materials Science and State Key Laboratory of Molecular Engineering 
      of Polymers, Fudan University, Shanghai, 200438, P. R. China.
FAU - Jin, Dayong
AU  - Jin D
AD  - Institute for Biomedical Materials & Devices (IBMD), Faculty of Science, 
      University of Technology Sydney, New South Wales, 2007, Australia.
FAU - Bu, Wenbo
AU  - Bu W
AUID- ORCID: 0000-0001-6664-3453
AD  - Departments of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan 
      University, Shanghai, 200040, P. R. China.
AD  - Department of Materials Science and State Key Laboratory of Molecular Engineering 
      of Polymers, Fudan University, Shanghai, 200438, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230302
PL  - Germany
TA  - Angew Chem Int Ed Engl
JT  - Angewandte Chemie (International ed. in English)
JID - 0370543
RN  - 3352-57-6 (Hydroxyl Radical)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Humans
MH  - *Neoplasms/drug therapy
MH  - *Nanoparticles/chemistry
MH  - Hydroxyl Radical/metabolism
MH  - Oxidative Stress
MH  - Hydrogen Peroxide/metabolism
MH  - Cell Line, Tumor
OTO - NOTNLM
OT  - Antitumor Agent
OT  - Built-in Electron Field
OT  - Chemodynamic Therapy
OT  - Fenton Reaction
OT  - Radicals
EDAT- 2023/02/14 06:00
MHDA- 2023/03/28 17:13
CRDT- 2023/02/13 11:33
PHST- 2023/01/09 00:00 [received]
PHST- 2023/03/28 17:13 [medline]
PHST- 2023/02/14 06:00 [pubmed]
PHST- 2023/02/13 11:33 [entrez]
AID - 10.1002/anie.202300356 [doi]
PST - ppublish
SO  - Angew Chem Int Ed Engl. 2023 Apr 3;62(15):e202300356. doi: 
      10.1002/anie.202300356. Epub 2023 Mar 2.