PMID- 36780623
OWN - NLM
STAT- MEDLINE
DCOM- 20230216
LR  - 20230216
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 333
DP  - 2022 Dec
TI  - CLINICAL AND IMMUNOLOGICAL PROFILE OF NEWLY DIAGNOSED DIABETIC PATIENTS IN A 
      COHORT OF YOUNG ADULTS OF NATIONAL HEPATITIS C VIRUS SURVEY IN EGYPT.
PG  - 51-56
AB  - T2DM (Type 2 diabetes mellitus) is considered a disease that affects old age 
      group. Recently, it has become common in children, adolescents and adults. Aim of 
      the work - to highlight the challenges in differentiating T1DM (type1 diabetes 
      mellitus) from T2DM (type2 diabetes mellitus) in early onset diabetes in youth 
      depending on clinical and laboratory characteristics. Our cross-sectional study 
      was performed on 200 newly diagnosed diabetic patients aged (18-30) years. All 
      patients were subjected to detailed medical history and full clinical 
      examination. Laboratory investigations included FBS, 2hPP, HbA1C, fasting C 
      peptide and GADA. About 59% (118) of our patients were T2DM while (82) 41% were 
      T1DM. T1DM was more dominant than T2DM in age group less than 25 years (T1DM 79% 
      versus T2DM 21%, P<0.001), while T2DM was more than T1DM in age group more than 
      25 years (T2DM 93% versus T1DM 17%, P<0.001). GADA was detected in 73.2% of T1DM 
      patient and it was high titer while GADA was detected in only 8% of T2DM with low 
      titer, in addition GADA positive patients were significantly younger than 
      negative patients, age (20.9+/-2.5 years vs. 26.4+/-3.5 years respectively) (P 
      <0.001). About 8% of phenotypically type 2 diabetic youth had GADA positive 
      antibodies which did not confer impact on c peptide level or glycemic control yet 
      type 1 diabetics who were GADA negative had a better glycemic control.
FAU - Halawa, M
AU  - Halawa M
AD  - 1Department of Internal Medicine and Endocrinology, Ain shams university, Egypt.
FAU - Elhefnawy, M
AU  - Elhefnawy M
AD  - 2National Institute of Diabetes and Endocrinology, Egypt.
FAU - Eid, Y
AU  - Eid Y
AD  - 1Department of Internal Medicine and Endocrinology, Ain shams university, Egypt.
FAU - Elhalawany, S
AU  - Elhalawany S
AD  - 1Department of Internal Medicine and Endocrinology, Ain shams university, Egypt.
FAU - Hegab, A
AU  - Hegab A
AD  - 2National Institute of Diabetes and Endocrinology, Egypt.
FAU - Hendawy, L
AU  - Hendawy L
AD  - 1Department of Internal Medicine and Endocrinology, Ain shams university, Egypt.
LA  - eng
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
RN  - 0 (Autoantibodies)
RN  - 0 (C-Peptide)
SB  - IM
MH  - Adolescent
MH  - Humans
MH  - Young Adult
MH  - Autoantibodies
MH  - C-Peptide
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 1/complications/diagnosis
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Egypt/epidemiology
MH  - Hepacivirus
EDAT- 2023/02/14 06:00
MHDA- 2023/02/16 06:00
CRDT- 2023/02/13 16:32
PHST- 2023/02/13 16:32 [entrez]
PHST- 2023/02/14 06:00 [pubmed]
PHST- 2023/02/16 06:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2022 Dec;(333):51-56.