PMID- 36782216
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230217
IS  - 1749-8546 (Print)
IS  - 1749-8546 (Electronic)
IS  - 1749-8546 (Linking)
VI  - 18
IP  - 1
DP  - 2023 Feb 13
TI  - Variable importance for projection (VIP) scores for analyzing the contribution of 
      risk factors in severe adverse events to Xiyanping injection.
PG  - 15
LID - 10.1186/s13020-023-00718-8 [doi]
LID - 15
AB  - BACKGROUND: Age and herb-drug combination are risk factors for the severity of 
      Xiyanping injection (XYP) associated adverse events (AEs). OBJECTIVE: To analyze 
      risk factors contributing to the severity of XYP's AEs using a variable 
      importance for projection (VIP) method. METHODS: AEs related to the use of XYP 
      were extracted from the China National Adverse Drug Reaction Monitoring 
      Information System (2004-2017) and classified as general or severe. Data were 
      analyzed with respect to age and 12 herb-drug combinations, including ribavirin 
      (RB), ceftriaxone, penicillin sodium, ambroxol hydrochloride (AH), clindamycin, 
      cefoxitin sodium, azithromycin (AZM), ceftazidime, amoxicillin sodium/potassium 
      clavulanate, levofloxacin hydrochloride, sodium cefazolin pentahydrate, and 
      acyclovir according to VIP scores and correlation coefficient (Coeff). RESULTS: A 
      total of 21,714 AEs (general 20,660; severe 1054) related to XYP combinations 
      were included. Using XYP alone tended to produce general AEs (All VIP = 3.124; 
      1.329; 1.857; 2.169; 2.400, Coeff < 0). For all set, 0-6 years old patients tend 
      to have general AEs (VIP = 2.425, Coeff < 0), while those > 41 years old patients 
      tend to have severe AEs (VIP = 1.180; 2.323, Coeff > 0). For 0-40 years old 
      patients, XYP-RB combination had a greater impact on the severity of AEs 
      (VIP = 1.158; 1.360; 1.147, Coeff > 0). For 7-17 years old patients, XYP-AZM 
      combination tended to produce general AEs (VIP = 1.502, Coeff < 0). In 
      individuals > 65 years old, XYP-AH combination tended to result in severe AEs 
      (VIP = 1.232, Coeff > 0). CONCLUSIONS: VIP method was expected to effectively 
      analyze risk factors in affecting the severity of AEs and control AEs more 
      effectively. Age is the key factor contributing to the severity of AEs, and there 
      are different influence directions. It is recommended that clinicians pay closer 
      attention to the metabolic characteristics of different age groups. It is safe to 
      use XYP alone and strictly implementing standardized operations such as 
      medication interval and flushing will avoid undesired AEs.
CI  - (c) 2023. The Author(s).
FAU - Zheng, Rui
AU  - Zheng R
AD  - Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, 
      Dongzhimen Hospital, Beijing University of Chinese Medicine, Haiyuncang Lane 5, 
      Dongcheng District, Beijing, 100700, China.
FAU - Chen, Zhao
AU  - Chen Z
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese 
      Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Dongcheng District, Beijing, 
      China.
FAU - Guan, Zhiyue
AU  - Guan Z
AD  - Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, 
      Dongzhimen Hospital, Beijing University of Chinese Medicine, Haiyuncang Lane 5, 
      Dongcheng District, Beijing, 100700, China.
FAU - Zhao, Chen
AU  - Zhao C
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese 
      Medical Sciences, No. 16, Nanxiaojie, Dongzhimennei, Dongcheng District, Beijing, 
      China.
FAU - Cui, Herong
AU  - Cui H
AD  - Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, 
      Dongzhimen Hospital, Beijing University of Chinese Medicine, Haiyuncang Lane 5, 
      Dongcheng District, Beijing, 100700, China.
AD  - School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, 
      China.
FAU - Shang, Hongcai
AU  - Shang H
AD  - Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, 
      Dongzhimen Hospital, Beijing University of Chinese Medicine, Haiyuncang Lane 5, 
      Dongcheng District, Beijing, 100700, China. shanghongcai@126.com.
LA  - eng
GR  - W02020052/National Ten Thousand Talent Program/
GR  - 82204937/National Natural Science Foundation of China/
GR  - 2020-QNRC1-04/Young Elite Scientists Sponsorship Program by CAST/
PT  - Journal Article
DEP - 20230213
PL  - England
TA  - Chin Med
JT  - Chinese medicine
JID - 101265109
PMC - PMC9923652
OTO - NOTNLM
OT  - Adverse events
OT  - Age
OT  - Herb-drug combination
OT  - Herb-drug interaction
OT  - Ribavirin
OT  - Risk factor
OT  - Safety
OT  - Severity
OT  - Variable importance for projection
OT  - Xiyanping injection
COIS- The authors declare that they have no competing interests.
EDAT- 2023/02/15 06:00
MHDA- 2023/02/15 06:01
PMCR- 2023/02/13
CRDT- 2023/02/14 00:13
PHST- 2022/10/07 00:00 [received]
PHST- 2023/01/30 00:00 [accepted]
PHST- 2023/02/14 00:13 [entrez]
PHST- 2023/02/15 06:00 [pubmed]
PHST- 2023/02/15 06:01 [medline]
PHST- 2023/02/13 00:00 [pmc-release]
AID - 10.1186/s13020-023-00718-8 [pii]
AID - 718 [pii]
AID - 10.1186/s13020-023-00718-8 [doi]
PST - epublish
SO  - Chin Med. 2023 Feb 13;18(1):15. doi: 10.1186/s13020-023-00718-8.