PMID- 36786549
OWN - NLM
STAT- MEDLINE
DCOM- 20230216
LR  - 20230522
IS  - 1465-2080 (Electronic)
IS  - 1350-0872 (Print)
IS  - 1350-0872 (Linking)
VI  - 169
IP  - 2
DP  - 2023 Feb
TI  - Prevalence of multidrug-resistant coagulase-positive staphylococci in canine and 
      feline dermatological patients over a 10-year period: a retrospective study.
LID - 10.1099/mic.0.001300 [doi]
LID - 001300
AB  - Coagulase-positive staphylococci (CPS) are common cutaneous pathogens often 
      requiring multiple courses of antibiotics, which may facilitate selection for 
      methicillin-resistant (MR) and/or multidrug-resistant (MDR) strains. To determine 
      the prevalence of canine and feline MR/MDR CPS associated with skin diseases, 
      medical records were retrospectively searched from April 2010 to April 2020. Pets 
      with at least one positive culture for CPS were selected. Age, sex, antimicrobial 
      sensitivity, previous history of antimicrobial/immunomodulatory medications and 
      methicillin resistance/multidrug resistance status were recorded. Staphylococcus 
      pseudintermedius (SP) (575/748) and Staphylococcus schleiferi (SS) (159/748) in 
      dogs, and Staphylococcus aureus (12/22) in cats, were the most common CPS 
      isolated. Three hundred and twenty-three out of 575 isolates were MR-SP (56.2 %), 
      304/575 were MDR-SP (52.8 %), 100/159 were MR-SS (62.9 %) and 71/159 were MDR-SS 
      (44.6 %). A trend analysis showed a significant increase of resistance to 
      oxacillin and chloramphenicol for S. pseudintermedius (r=0.86, 0.8; P=0.0007, 
      0.0034, respectively). Major risk factors for MDR-SP included oxacillin 
      resistance (OR: 3; 95 % CI: 1.4-6.5; P=0.0044), positivity for PBP2a (OR: 2.3; 
      95 % CI: 1-5; P=0.031) and use of antibiotics in the previous year (OR: 2.8; 
      95 % CI: 1.3-5.8; P=0.0071). Oxacillin resistance was identified as a major risk 
      factor for MDR-SS (OR: 8.8; 95 % CI: 3.6-21.1; P<0.0001). These results confirmed 
      the widespread presence of MR/MDR CPS in referred dermatological patients. 
      Judicious antibiotic use, surveillance for MR/MDR infections and consideration of 
      alternative therapies are crucial in mitigating the development of resistant 
      strains.
FAU - Burke, Mikaela
AU  - Burke M
AD  - Department of Small Animal Clinical Sciences, College of Veterinary Medicine, 
      University of Florida, 2015 SW 16th Ave Gainesville, FL 32610, USA.
FAU - Santoro, Domenico
AU  - Santoro D
AD  - Department of Small Animal Clinical Sciences, College of Veterinary Medicine, 
      University of Florida, 2015 SW 16th Ave Gainesville, FL 32610, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Microbiology (Reading)
JT  - Microbiology (Reading, England)
JID - 9430468
RN  - 0 (Coagulase)
RN  - 0 (Anti-Bacterial Agents)
RN  - UH95VD7V76 (Oxacillin)
RN  - Staphylococcus pseudintermedius
RN  - Staphylococcus schleiferi
SB  - IM
MH  - Cats
MH  - Animals
MH  - Dogs
MH  - Retrospective Studies
MH  - Coagulase/genetics
MH  - Prevalence
MH  - *Cat Diseases/epidemiology
MH  - *Dog Diseases/epidemiology
MH  - *Staphylococcal Infections/epidemiology/veterinary
MH  - Anti-Bacterial Agents/pharmacology
MH  - Oxacillin
MH  - Microbial Sensitivity Tests
PMC - PMC10197874
OTO - NOTNLM
OT  - cats
OT  - coagulase-positive staphylococci
OT  - dermatology
OT  - dogs
OT  - multidrug resistance
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2023/02/15 06:00
MHDA- 2023/02/17 06:00
PMCR- 2023/02/14
CRDT- 2023/02/14 08:52
PHST- 2023/02/14 08:52 [entrez]
PHST- 2023/02/15 06:00 [pubmed]
PHST- 2023/02/17 06:00 [medline]
PHST- 2023/02/14 00:00 [pmc-release]
AID - 001300 [pii]
AID - 10.1099/mic.0.001300 [doi]
PST - ppublish
SO  - Microbiology (Reading). 2023 Feb;169(2):001300. doi: 10.1099/mic.0.001300.