PMID- 36786663
OWN - NLM
STAT- MEDLINE
DCOM- 20230331
LR  - 20230401
IS  - 1939-1676 (Electronic)
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 37
IP  - 2
DP  - 2023 Mar
TI  - Effect of withholding food versus feeding on creatinine, symmetric 
      dimethylarginine, cholesterol, triglycerides, and other biochemical analytes in 
      100 healthy dogs.
PG  - 626-634
LID - 10.1111/jvim.16630 [doi]
AB  - BACKGROUND: Withholding food is often recommended before collection of blood for 
      routine biochemical analysis in dogs despite a paucity of evidence to support 
      this requirement. OBJECTIVES: To compare measurements of selected biochemical 
      analytes collected before and after feeding in clinically healthy dogs. ANIMALS: 
      One hundred clinically healthy staff- and student-owned dogs weighing >/=15 kg. 
      METHODS: Prospective observational study. Food was withheld from the dogs for 
      10-26 hours. Preprandial serum was collected, and then dogs were fed their usual 
      food at an amount equivalent to at least 2/3 resting energy requirement (RER). 
      Selected serum analytes were measured at 2-, 4-, 6-, and 8-hours postprandially. 
      The proportion of postprandial values that exceeded either the reported allowable 
      total error (TEa), or for symmetric dimethylarginine (SDMA), the reference change 
      value (RCV), was determined. As neither TEa nor RCV is available for lipase, 
      comparison was made to the high end of the reference interval (RI). RESULTS: The 
      proportion of dogs with at least 1 postprandial measurement that exceeded the TEa 
      or RCV was 92/100 for triglycerides, 66/100 for blood urea nitrogen (BUN), 46/100 
      for phosphorus, 17/100 for glucose, 9/100 for bilirubin, 5/100 for SDMA, 2/100 
      for creatinine, and 0/100 for cholesterol and albumin. Postprandial lipase never 
      exceeded the RI in dogs with normal fasted lipase. CONCLUSIONS AND CLINICAL 
      IMPORTANCE: Withholding food is generally not necessary before performing routine 
      biochemical analysis in clinically healthy dogs. Withholding food might be 
      helpful to limit variability in analytes impacted by feeding, such as 
      triglycerides and phosphorus.
CI  - (c) 2023 The Authors. Journal of Veterinary Internal Medicine published by Wiley 
      Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
FAU - Yi, Katarina C
AU  - Yi KC
AUID- ORCID: 0000-0001-5646-5374
AD  - Department of Small Animal Clinical Sciences, College of Veterinary Medicine and 
      Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
FAU - Heseltine, Johanna C
AU  - Heseltine JC
AD  - Department of Small Animal Clinical Sciences, College of Veterinary Medicine and 
      Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
FAU - Jeffery, Nicholas D
AU  - Jeffery ND
AUID- ORCID: 0000-0002-9812-1788
AD  - Department of Small Animal Clinical Sciences, College of Veterinary Medicine and 
      Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
FAU - Cook, Audrey K
AU  - Cook AK
AUID- ORCID: 0000-0002-2840-6497
AD  - Department of Small Animal Clinical Sciences, College of Veterinary Medicine and 
      Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
FAU - Nabity, Mary B
AU  - Nabity MB
AUID- ORCID: 0000-0001-6787-822X
AD  - Department of Veterinary Pathobiology, College of Veterinary Medicine and 
      Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
LA  - eng
GR  - GINN fund/
PT  - Journal Article
PT  - Observational Study, Veterinary
DEP - 20230214
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - 0 (Triglycerides)
RN  - AYI8EX34EU (Creatinine)
RN  - 49787G1ULV (symmetric dimethylarginine)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 3.1.1.3 (Lipase)
SB  - IM
MH  - Dogs
MH  - Animals
MH  - Triglycerides
MH  - Creatinine
MH  - *Cholesterol
MH  - *Lipase
PMC - PMC10061199
OTO - NOTNLM
OT  - canine
OT  - hyperlipidemia
OT  - hypertriglyceridemia
OT  - postprandial
OT  - renal
COIS- Authors declare no conflict of interest.
EDAT- 2023/02/15 06:00
MHDA- 2023/03/31 06:42
PMCR- 2023/02/14
CRDT- 2023/02/14 09:32
PHST- 2022/05/30 00:00 [received]
PHST- 2023/01/05 00:00 [accepted]
PHST- 2023/03/31 06:42 [medline]
PHST- 2023/02/15 06:00 [pubmed]
PHST- 2023/02/14 09:32 [entrez]
PHST- 2023/02/14 00:00 [pmc-release]
AID - JVIM16630 [pii]
AID - 10.1111/jvim.16630 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2023 Mar;37(2):626-634. doi: 10.1111/jvim.16630. Epub 2023 Feb 
      14.