PMID- 36787174 OWN - NLM STAT- MEDLINE DCOM- 20230216 LR - 20240210 IS - 2474-9842 (Electronic) IS - 2474-9842 (Linking) VI - 7 IP - 1 DP - 2023 Jan 6 TI - Short-term outcomes of health-related quality of life in patients with locally recurrent rectal cancer: multicentre, international, cross-sectional cohort study. LID - 10.1093/bjsopen/zrac168 [doi] LID - zrac168 AB - BACKGROUND: Overall survival rates for locally recurrent rectal cancer (LRRC) continue to improve but the evidence concerning health-related quality of life (HrQoL) remains limited. The aim of this study was to describe the short-term HrQoL differences between patients undergoing surgical and palliative treatments for LRRC. METHODS: An international, cross-sectional, observational study was undertaken at five centres across the UK and Australia. HrQoL in LRRC patients was assessed using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-CR29 and functional assessment of cancer therapy - colorectal (FACT-C) questionnaires and subgroups (curative versus palliative) were compared. Secondary analyses included the comparison of HrQoL according to the margin status, location of disease and type of treatment. Scores were interpreted using minimal clinically important differences (MCID) and Cohen effect size (ES). RESULTS: Out of 350 eligible patients, a total of 95 patients participated, 74.0 (78.0 per cent) treated with curative intent and 21.0 (22.0 per cent) with palliative intent. Median time between LRRC diagnosis and HrQoL assessments was 4 months. Higher overall FACT-C scores denoting better HrQoL were observed in patients undergoing curative treatment, demonstrating a MCID with a mean difference of 18.5 (P < 0.001) and an ES of 0.6. Patients undergoing surgery had higher scores denoting a higher burden of symptoms for the EORTC CR29 domains of urinary frequency (P < 0.001, ES 0.3) and frequency of defaecation (P < 0.001, ES 0.4). Higher overall FACT-C scores were observed in patients who underwent an R0 resection versus an R1 resection (P = 0.051, ES 0.6). EORTC CR29 scores identified worse body image in patients with posterior/central disease (P = 0.021). Patients undergoing palliative chemoradiation reported worse HrQoL scores with a higher symptom burden on the frequency of defaecation scale compared with palliative chemotherapy (P = 0.041). CONCLUSION: Several differences in short-term HrQoL outcomes between patients undergoing curative and palliative treatment for LRRC were documented. Patients undergoing curative surgery reported better overall HrQoL and a higher burden of pelvic symptoms. CI - (c) The Author(s) 2023. Published by Oxford University Press on behalf of BJS Society Ltd. FAU - Harji, Deena P AU - Harji DP AD - Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK. AD - Department of Colorectal Surgery, Manchester University NHS Foundation Trust, Manchester, UK. FAU - McKigney, Niamh AU - McKigney N AD - Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK. FAU - Koh, Cherry AU - Koh C AD - Surgical Outcomes Research Centre (SOuRCe), Royal Prince Alfred Hospital, Sydney, NSW, Australia. AD - Faculty of Medicine and Health, Central Clinical School, The University of Sydney, Sydney, NSW, Australia. AD - Royal Prince Alfred Hospital, RPA Institute of Academic Surgery, Sydney, NSW, Australia. AD - Department of Colorectal Surgery, Royal Prince Alfred Hospital, Sydney, NSW, Australia. FAU - Solomon, Michael J AU - Solomon MJ AD - Surgical Outcomes Research Centre (SOuRCe), Royal Prince Alfred Hospital, Sydney, NSW, Australia. AD - Faculty of Medicine and Health, Central Clinical School, The University of Sydney, Sydney, NSW, Australia. AD - Royal Prince Alfred Hospital, RPA Institute of Academic Surgery, Sydney, NSW, Australia. AD - Department of Colorectal Surgery, Royal Prince Alfred Hospital, Sydney, NSW, Australia. FAU - Griffiths, Ben AU - Griffiths B AD - Department of Colorectal Surgery, Manchester University NHS Foundation Trust, Manchester, UK. FAU - Evans, Martyn AU - Evans M AD - Department of Colorectal Surgery, Heol Maes Eglwys, Morriston, Swansea, UK. FAU - Heriot, Alexander AU - Heriot A AD - Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia. FAU - Sagar, Peter M AU - Sagar PM AD - The John Goligher Department of Colorectal Surgery, St James's University Hospital, Leeds, UK. FAU - Velikova, Galina AU - Velikova G AUID- ORCID: 0000-0003-1899-5942 AD - Leeds Institute of Medical Research, University of Leeds, Leeds, UK. AD - St James's Institute of Oncology, St James's University Hospital, Leeds, UK. FAU - Brown, Julia M AU - Brown JM AD - Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK. LA - eng GR - 25447/CRUK_/Cancer Research UK/United Kingdom PT - Journal Article PT - Multicenter Study PT - Observational Study PL - England TA - BJS Open JT - BJS open JID - 101722685 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Quality of Life MH - Neoplasm Recurrence, Local/surgery MH - *Rectal Neoplasms/surgery MH - Cohort Studies PMC - PMC9927560 EDAT- 2023/02/15 06:00 MHDA- 2023/02/17 06:00 PMCR- 2023/02/14 CRDT- 2023/02/14 11:53 PHST- 2022/05/04 00:00 [received] PHST- 2022/11/23 00:00 [revised] PHST- 2022/12/02 00:00 [accepted] PHST- 2023/02/14 11:53 [entrez] PHST- 2023/02/15 06:00 [pubmed] PHST- 2023/02/17 06:00 [medline] PHST- 2023/02/14 00:00 [pmc-release] AID - 7036348 [pii] AID - zrac168 [pii] AID - 10.1093/bjsopen/zrac168 [doi] PST - ppublish SO - BJS Open. 2023 Jan 6;7(1):zrac168. doi: 10.1093/bjsopen/zrac168.