PMID- 36787322
OWN - NLM
STAT- MEDLINE
DCOM- 20230216
LR  - 20230407
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 18
IP  - 2
DP  - 2023
TI  - Pain phenotyping and investigation of outcomes in physical therapy: An 
      exploratory study in patients with low back pain.
PG  - e0281517
LID - 10.1371/journal.pone.0281517 [doi]
LID - e0281517
AB  - Phenotypes have been proposed as a method of characterizing subgroups based on 
      biopsychosocial factors to identify responders to analgesic treatments. This 
      study aimed to, first, confirm phenotypes in patients with low back pain 
      receiving physical therapy based on an a priori set of factors used to derive 
      subgroups in other pain populations. Second, an exploratory analysis examined if 
      phenotypes differentiated pain and disability outcomes at four weeks of physical 
      therapy. Fifty-five participants completed psychological questionnaires and 
      pressure pain threshold (PPT). Somatization, anxiety, and depression domains of 
      the Symptom-Checklist-90-Revised, and PPT, were entered into a hierarchical 
      agglomerative cluster analysis with Ward's method to identify phenotypes. 
      Repeated measures ANOVAs assessed pain ratings and disability by phenotype at 
      four weeks. Three clusters emerged: 1) high emotional distress and pain 
      sensitivity (n = 10), 2) low emotional distress (n = 34), 3) low pain sensitivity 
      (n = 11). As an exploratory study, clusters did not differentiate pain ratings or 
      disability after four weeks of physical therapy (p's>0.05). However, trends were 
      observed as magnitude of change for pain varied by phenotype. This supports the 
      characterization of homogenous subgroups based on a protocol conducted in the 
      clinical setting with varying effect sizes noted by phenotype for short-term 
      changes in pain. As an exploratory study, future studies should aim to repeat 
      this trial in a larger sample of patients.
CI  - Copyright: (c) 2023 Wilson et al. This is an open access article distributed under 
      the terms of the Creative Commons Attribution License, which permits unrestricted 
      use, distribution, and reproduction in any medium, provided the original author 
      and source are credited.
FAU - Wilson, Abigail T
AU  - Wilson AT
AUID- ORCID: 0000-0001-9740-5917
AD  - School of Kinesiology and Rehabilitation Sciences, College of Health Professions 
      and Sciences, University of Central Florida, Orlando, Florida, United States of 
      America.
FAU - Riley, Joseph L 3rd
AU  - Riley JL 3rd
AD  - Department of Community Dentistry and Behavioral Science, University of Florida, 
      Gainesville, Florida, United States of America.
AD  - Pain Research & Intervention Center of Excellence, University of Florida, 
      Gainesville, Florida, United States of America.
FAU - Bishop, Mark D
AU  - Bishop MD
AD  - University of Florida Department of Physical Therapy, Gainesville, Florida, 
      United States of America.
FAU - Beneciuk, Jason M
AU  - Beneciuk JM
AD  - University of Florida Department of Physical Therapy, Gainesville, Florida, 
      United States of America.
AD  - Clinical Research Center, Brooks Rehabilitation, Jacksonville, Florida, United 
      States of America.
FAU - Cruz-Almeida, Yenisel
AU  - Cruz-Almeida Y
AD  - Department of Community Dentistry and Behavioral Science, University of Florida, 
      Gainesville, Florida, United States of America.
AD  - Pain Research & Intervention Center of Excellence, University of Florida, 
      Gainesville, Florida, United States of America.
FAU - Markut, Keri
AU  - Markut K
AD  - University of Florida Health Rehab Center-Orthopedic and Sports Medicine 
      Institute, Gainesville, Florida, United States of America.
FAU - Redd, Charlotte
AU  - Redd C
AD  - University of Florida Health Rehab Center-Orthopedic and Sports Medicine 
      Institute, Gainesville, Florida, United States of America.
FAU - LeBlond, Nicholas
AU  - LeBlond N
AD  - Duke University Health System Durham, North Carolina, United States of America.
FAU - Pham, Patrick H
AU  - Pham PH
AD  - Brooks Rehabilitation, Jacksonville, Florida, United States of America.
FAU - Shirey, David
AU  - Shirey D
AD  - Brooks Rehabilitation, Jacksonville, Florida, United States of America.
FAU - Bialosky, Joel E
AU  - Bialosky JE
AD  - University of Florida Department of Physical Therapy, Gainesville, Florida, 
      United States of America.
AD  - Clinical Research Center, Brooks Rehabilitation, Jacksonville, Florida, United 
      States of America.
LA  - eng
GR  - UL1 TR000064/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20230214
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Humans
MH  - *Low Back Pain/psychology
MH  - Pain Measurement/methods
MH  - Pain Threshold
MH  - Surveys and Questionnaires
MH  - Physical Therapy Modalities
MH  - Disability Evaluation
PMC - PMC9928110
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/02/15 06:00
MHDA- 2023/02/17 06:00
PMCR- 2023/02/14
CRDT- 2023/02/14 13:34
PHST- 2022/11/10 00:00 [received]
PHST- 2023/01/25 00:00 [accepted]
PHST- 2023/02/14 13:34 [entrez]
PHST- 2023/02/15 06:00 [pubmed]
PHST- 2023/02/17 06:00 [medline]
PHST- 2023/02/14 00:00 [pmc-release]
AID - PONE-D-22-31058 [pii]
AID - 10.1371/journal.pone.0281517 [doi]
PST - epublish
SO  - PLoS One. 2023 Feb 14;18(2):e0281517. doi: 10.1371/journal.pone.0281517. 
      eCollection 2023.