PMID- 36788484
OWN - NLM
STAT- MEDLINE
DCOM- 20230216
LR  - 20230221
IS  - 1471-2318 (Electronic)
IS  - 1471-2318 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Feb 14
TI  - Associations between transitions of intrinsic capacity and frailty status, and 
      3-year disability.
PG  - 96
LID - 10.1186/s12877-023-03795-4 [doi]
LID - 96
AB  - BACKGROUND: The trajectory of frailty and intrinsic capacity (IC) often overlap 
      in older adults. Longitudinal analyses of transitions of frailty and IC, and 
      their associations with incident functional decline are limited. The present 
      study aimed to identify transitions of frailty status and IC, and explore 
      associations between transitions of frailty and IC, and future disability among 
      community-dwelling older adults. METHODS: In the West China and Aging Trend 
      Study, 808 participants aged >/= 60 years completed baseline and three years 
      follow-up (frailty, IC and disability assessments). Physical frailty was measured 
      based on Fried phenotype. IC was evaluated by five domains (cognition, 
      locomotion, sensory, psychological, and vitality). Disability was defined as a 
      need for assistance in any items in activity of daily living (ADL) or the 
      instrumental activity of daily living (IADL). Logistic regressions were performed 
      to examine their relationships. RESULTS: Four transitions of IC status (kept 
      well: 27.4%, improved: 8.4%, worsened: 35.4%, and kept poor: 28.8%), and two 
      transitions of frailty status (kept not-frail/improved: 93.2%, kept 
      frail/worsened: 6.8%) were identified. Impaired locomotion and vitality at 
      baseline were significantly associated with kept frail or worsened frail. 
      However, impaired sensory and vitality at baseline not frailty status was 
      significantly associated with transitions of IC. Adjusted for covariates and 
      transitions of frailty, kept poor IC was associated with ADL (OR = 2.26, 
      95%CI = 1.17,4.34) and IADL disability (OR = 3.74, 95%CI = 1.79, 7.82). 
      CONCLUSIONS: Transitions of IC, but not frailty were associated with higher risk 
      of incident disability. Baseline locomotion and vitality impairment were 
      associated with worsened or kept frail. Our findings support the WHO's notion of 
      monitoring and optimizing IC to delay deterioration of IC and preventing frailty 
      and disability. CLINICAL TRIAL NUMBER: ChiCTR1800018895.
CI  - (c) 2023. The Author(s).
FAU - Jia, Shuli
AU  - Jia S
AD  - National Clinical Research Center of Geriatrics, West China Hospital, Sichuan 
      University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China.
FAU - Zhao, Wanyu
AU  - Zhao W
AD  - National Clinical Research Center of Geriatrics, West China Hospital, Sichuan 
      University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China.
AD  - Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, 
      No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China.
FAU - Ge, Meiling
AU  - Ge M
AD  - National Clinical Research Center of Geriatrics, West China Hospital, Sichuan 
      University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China.
AD  - Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, 
      No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China.
FAU - Xia, Xin
AU  - Xia X
AD  - National Clinical Research Center of Geriatrics, West China Hospital, Sichuan 
      University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China.
AD  - Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, 
      No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China.
FAU - Hu, Fengjuan
AU  - Hu F
AD  - National Clinical Research Center of Geriatrics, West China Hospital, Sichuan 
      University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China.
FAU - Hao, Qiukui
AU  - Hao Q
AD  - National Clinical Research Center of Geriatrics, West China Hospital, Sichuan 
      University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China.
AD  - Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, 
      No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China.
AD  - School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - National Clinical Research Center of Geriatrics, West China Hospital, Sichuan 
      University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China.
FAU - Yang, Mei
AU  - Yang M
AD  - National Clinical Research Center of Geriatrics, West China Hospital, Sichuan 
      University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China.
FAU - Yue, Jirong
AU  - Yue J
AD  - National Clinical Research Center of Geriatrics, West China Hospital, Sichuan 
      University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China.
AD  - Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, 
      No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China.
FAU - Dong, Birong
AU  - Dong B
AD  - National Clinical Research Center of Geriatrics, West China Hospital, Sichuan 
      University, No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China. 
      birongdong123@outlook.com.
AD  - Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, 
      No. 37, Guo Xue Xiang Renmin Nan Lu, Chengdu, 610041, Sichuan, China. 
      birongdong123@outlook.com.
LA  - eng
GR  - Z2021JC003/National Clinical Research Center for Geriatrics，West China Hospital, 
      Sichuan University/
GR  - 2019YF0900083SN/Chengdu Science and Technology Bureau Major Science and 
      Technology Application Demonstration Project/
GR  - 2020YFC200560/National Key R&D Program of China/
GR  - ZYGD20010/1.3.5 project for disciplines of excellence, West China Hospital, 
      Sichuan University/
GR  - 2017YFC0840101/National Key R&D Program of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230214
PL  - England
TA  - BMC Geriatr
JT  - BMC geriatrics
JID - 100968548
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Frail Elderly/psychology
MH  - Geriatric Assessment
MH  - *Frailty/diagnosis/epidemiology/complications
MH  - Activities of Daily Living/psychology
MH  - Independent Living
PMC - PMC9930336
OTO - NOTNLM
OT  - Disability
OT  - Frailty
OT  - Functional decline
OT  - Healthy aging
OT  - Intrinsic capacity
COIS- The authors declare that they have no competing interest.
EDAT- 2023/02/16 06:00
MHDA- 2023/02/17 06:00
PMCR- 2023/02/14
CRDT- 2023/02/15 00:23
PHST- 2022/09/01 00:00 [received]
PHST- 2023/02/02 00:00 [accepted]
PHST- 2023/02/15 00:23 [entrez]
PHST- 2023/02/16 06:00 [pubmed]
PHST- 2023/02/17 06:00 [medline]
PHST- 2023/02/14 00:00 [pmc-release]
AID - 10.1186/s12877-023-03795-4 [pii]
AID - 3795 [pii]
AID - 10.1186/s12877-023-03795-4 [doi]
PST - epublish
SO  - BMC Geriatr. 2023 Feb 14;23(1):96. doi: 10.1186/s12877-023-03795-4.