PMID- 36788517
OWN - NLM
STAT- MEDLINE
DCOM- 20230216
LR  - 20230217
IS  - 2662-7671 (Electronic)
IS  - 2662-7671 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Feb 14
TI  - The effects of aqueous and ethanolic extracts of Rheum ribes on 
      insulin-resistance and apolipoproteins in patients with type 2 diabetes mellitus: 
      a randomized controlled trial.
PG  - 46
LID - 10.1186/s12906-023-03878-0 [doi]
LID - 46
AB  - BACKGROUND AND AIM: Previous studies have shown that Rheum ribes (R. ribes) could 
      be effective in controlling the blood glucose levels. This study was conducted to 
      determine the effects of R. ribes supplementation on glycemic indices and 
      apolipoproteins in patients with type 2 diabetes mellitus (T2DM). METHODS: In the 
      present randomized double-blind controlled trial, 60 type 2 diabetic patients 
      aged 30-60 years with a body mass index (BMI) of 20-30 kg/m(2) and hemoglobin A1c 
      (HbA1c) of 6-8% were enrolled. Patients were randomly assigned to receive 450 mg 
      of aqueous R. ribes extract (AG), 450 mg of ethanolic R. ribes extract (EG), or 
      placebo (PG) three times daily for 6 weeks. At the baseline and at the end of the 
      study, blood glucose levels, homeostatic model assessment of insulin resistance 
      (HOMA-IR) and the homeostatic model assessment of beta-cell dysfunction (HOMA-B), as 
      well as apolipoprotein A-I (ApoA1) and apolipoprotein B (ApoB) were measured. 
      RESULTS: There was a significant decrease in the serum levels of insulin in AG 
      and EG groups (P = 0.003 and P = 0.001, respectively), HOMA-IR (P = 0.01 and 
      P = 0.001, respectively), HOMA-B (P = 0.002 and P = 0.001, respectively), ApoB 
      (P = 0.006 and P = 0.03, respectively), ApoB/ApoA1 ratio (P = 0.016 and P = 0.04, 
      respectively). However, a significant increase in ApoA1 (P = 0.08 and P = 0.05, 
      respectively) with no significant changes in blood glucose, at the end of study 
      compared to beginning values, were observed. None of the variables showed a 
      significant change in PG. At the end of the study; while there were significant 
      differences in insulin (P = 0.04), HOMA-IR (P = 0.03), HOMA-B (P = 0.01), ApoB 
      (P = 0.02), and ApoB/ApoA1 ratio (P = 0.03) among the groups but ApoA1 had no 
      significant change. CONCLUSION: Consumption of R. ribes intake could have 
      beneficial effects on insulin resistance and apolipoproteins in type 2 diabetic 
      patients. (Registered at en.irct.ir, identification number: IRCT201410142709N31).
CI  - (c) 2023. The Author(s).
FAU - Ghafouri, Atieh
AU  - Ghafouri A
AD  - Department of Nutrition, School of Public Health, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Jafari Karegar, Sahar
AU  - Jafari Karegar S
AD  - Department of Nutrition, School of Public Health, Iran University of Medical 
      Sciences, Tehran, Iran.
AD  - Student Research Committee, Faculty of Public Health Branch, Iran University of 
      Medical Sciences, Tehran, Iran.
FAU - Hajiluian, Ghazaleh
AU  - Hajiluian G
AD  - Department of Nutrition, School of Public Health, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Hosseini, Sharieh
AU  - Hosseini S
AD  - Department of Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical 
      Sciences, Islamic Azad University, Tehran, Iran.
FAU - Shidfar, Shahrzad
AU  - Shidfar S
AD  - Worcester Memorial Hospital, University of Massachusetts, Worcester, MA, USA.
FAU - Kamalinejad, Mohammad
AU  - Kamalinejad M
AD  - School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Hosseini, Agha Fatemeh
AU  - Hosseini AF
AD  - Department of Statistics, School of Public Health, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Heydari, Iraj
AU  - Heydari I
AD  - Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Shidfar, Farzad
AU  - Shidfar F
AD  - Department of Nutrition, School of Public Health, Iran University of Medical 
      Sciences, Tehran, Iran. shidfar.f@iums.ac.ir.
AD  - Research Center for Prevention of Cardiovascular Diseases, Institute of 
      Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran. 
      shidfar.f@iums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20230214
PL  - England
TA  - BMC Complement Med Ther
JT  - BMC complementary medicine and therapies
JID - 101761232
RN  - 0 (Apolipoproteins B)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Humans
MH  - Apolipoproteins B
MH  - Blood Glucose
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Insulin
MH  - *Insulin Resistance
MH  - *Rheum
MH  - *Plant Extracts/therapeutic use
PMC - PMC9926739
OTO - NOTNLM
OT  - Apolipoproteins
OT  - Aqueous extract
OT  - Diabetes mellitus
OT  - Ethanolic extract
OT  - Rheum ribes
COIS- The authors declare no competing interests.
EDAT- 2023/02/16 06:00
MHDA- 2023/02/17 06:00
PMCR- 2023/02/14
CRDT- 2023/02/15 00:24
PHST- 2022/08/29 00:00 [received]
PHST- 2023/02/09 00:00 [accepted]
PHST- 2023/02/15 00:24 [entrez]
PHST- 2023/02/16 06:00 [pubmed]
PHST- 2023/02/17 06:00 [medline]
PHST- 2023/02/14 00:00 [pmc-release]
AID - 10.1186/s12906-023-03878-0 [pii]
AID - 3878 [pii]
AID - 10.1186/s12906-023-03878-0 [doi]
PST - epublish
SO  - BMC Complement Med Ther. 2023 Feb 14;23(1):46. doi: 10.1186/s12906-023-03878-0.