PMID- 36790917
OWN - NLM
STAT- MEDLINE
DCOM- 20230302
LR  - 20230930
IS  - 1535-1815 (Electronic)
IS  - 0749-5161 (Linking)
VI  - 39
IP  - 3
DP  - 2023 Mar 1
TI  - Clinical Features and Management of Status Epilepticus in the Pediatric Intensive 
      Care Unit.
PG  - 142-147
LID - 10.1097/PEC.0000000000002915 [doi]
AB  - OBJECTIVES: Status epilepticus (SE) is associated with significant morbidity and 
      mortality in children. SE in the pediatric intensive care unit (PICU) are not 
      well characterized. The aim of this study is to retrospectively investigate the 
      clinical features and treatment of seizures in children admitted to the PICU of 
      our hospital. METHODS: We retrospectively examined the clinical characteristics 
      of patients aged between 1 month and 18 years who were admitted to our hospital 
      with SE or who were diagnosed with SE after hospitalization and were followed up 
      with continuous electroencephalographic monitoring between January 2015 and 
      December 2019. RESULTS: A total of 88 patients with SE, 50 (56.8%) boys and 38 
      (43.2%) girls, were included. The median age was 24 months (interquartile range, 
      12-80 months). When we evaluate the continuous electroencephalographic monitoring 
      data, 27 (30.7%) were lateralized, 20 (22.7%) were multifocal, 30 (34.1%) were 
      generalized, and 11 (12.5%) were bilateral independent epileptic activity. 
      Seventy nine patients (89.8%) were evaluated as convulsive status epilepticus 
      (CSE) and 9 (10.2%) as nonconvulsive status epilepticus (NCSE). Pediatric Risk of 
      Mortality (PRISM III) score and mortality of patients with NCSE were higher ( P = 
      0.004 and P = 0.046, respectively). Thirteen eight patients (43.1%) were 
      diagnosed as SE, 38 patients (43.1%) as refractory SE, and 12 patients (13.6%) as 
      super-refractory SE. The overall mortality rate was 10.2%. CONCLUSIONS: Status 
      epilepticus is a neurological emergency that causes mortality and morbidity. 
      Electroencephalographic monitoring is important for the recognition of seizures 
      and rapid intervention. No superiority of second-line treatments or combined 
      treatments was demonstrated in patients with SE.
CI  - Copyright (c) 2023 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Soydan, Ekin
AU  - Soydan E
AUID- ORCID: 0000-0003-2626-5499
AD  - From the Pediatric Intensive Care Unit.
FAU - Guzin, Yigithan
AU  - Guzin Y
AUID- ORCID: 0000-0002-8748-5586
AD  - Department of Pediatric Neurology, Dr. Behcet Uz Children's Hospital, University 
      of Health Sciences, Izmir, Turkey.
FAU - Topal, Sevgi
AU  - Topal S
AUID- ORCID: 0000-0002-7725-5509
AD  - From the Pediatric Intensive Care Unit.
FAU - Atakul, Gulhan
AU  - Atakul G
AUID- ORCID: 0000-0002-3832-9691
AD  - From the Pediatric Intensive Care Unit.
FAU - Colak, Mustafa
AU  - Colak M
AUID- ORCID: 0000-0001-8310-3766
AD  - From the Pediatric Intensive Care Unit.
FAU - Seven, Pinar
AU  - Seven P
AUID- ORCID: 0000-0001-7305-9984
AD  - From the Pediatric Intensive Care Unit.
FAU - Sandal, Ozlem Sarac
AU  - Sandal OS
AUID- ORCID: 0000-0002-5414-4670
AD  - From the Pediatric Intensive Care Unit.
FAU - Ceylan, Gokhan
AU  - Ceylan G
AUID- ORCID: 0000-0002-1730-6968
AD  - From the Pediatric Intensive Care Unit.
FAU - Unalp, Aycan
AU  - Unalp A
AUID- ORCID: 0000-0002-3611-5059
AD  - Department of Pediatric Neurology, Dr. Behcet Uz Children's Hospital, University 
      of Health Sciences, Izmir, Turkey.
FAU - Agin, Hasan
AU  - Agin H
AUID- ORCID: 0000-0003-3306-8899
AD  - From the Pediatric Intensive Care Unit.
LA  - eng
PT  - Journal Article
DEP - 20230216
PL  - United States
TA  - Pediatr Emerg Care
JT  - Pediatric emergency care
JID - 8507560
SB  - IM
MH  - Male
MH  - Child
MH  - Female
MH  - Humans
MH  - Child, Preschool
MH  - Infant
MH  - Retrospective Studies
MH  - *Electroencephalography/adverse effects
MH  - *Status Epilepticus/diagnosis/drug therapy
MH  - Seizures
MH  - Intensive Care Units, Pediatric
COIS- Disclosure: The authors declare no conflict of interest.
EDAT- 2023/02/16 06:00
MHDA- 2023/03/03 06:00
CRDT- 2023/02/15 12:33
PHST- 2023/02/16 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2023/02/15 12:33 [entrez]
AID - 00006565-202303000-00006 [pii]
AID - 10.1097/PEC.0000000000002915 [doi]
PST - ppublish
SO  - Pediatr Emerg Care. 2023 Mar 1;39(3):142-147. doi: 10.1097/PEC.0000000000002915. 
      Epub 2023 Feb 16.