PMID- 36791205
OWN - NLM
STAT- MEDLINE
DCOM- 20230217
LR  - 20230405
IS  - 2375-2548 (Electronic)
IS  - 2375-2548 (Linking)
VI  - 9
IP  - 7
DP  - 2023 Feb 15
TI  - The link between neuroinflammation and the neurovascular unit in 
      synucleinopathies.
PG  - eabq1141
LID - 10.1126/sciadv.abq1141 [doi]
LID - eabq1141
AB  - The neurovascular unit (NVU) is composed of vascular cells, glial cells, and 
      neurons. As a fundamental functional module in the central nervous system, the 
      NVU maintains homeostasis in the microenvironment and the integrity of the 
      blood-brain barrier. Disruption of the NVU and interactions among its components 
      are involved in the pathophysiology of synucleinopathies, which are characterized 
      by the pathological accumulation of alpha-synuclein. Neuroinflammation contributes to 
      the pathophysiology of synucleinopathies, including Parkinson's disease, multiple 
      system atrophy, and dementia with Lewy bodies. This review aims to summarize the 
      neuroinflammatory response of glial cells and vascular cells in the NVU. We also 
      review neuroinflammation in the context of the cross-talk between glial cells and 
      vascular cells, between glial cells and pericytes, and between microglia and 
      astroglia. Last, we discuss how alpha-synuclein affects neuroinflammation and how 
      neuroinflammation influences the aggregation and spread of alpha-synuclein and 
      analyze different properties of alpha-synuclein in synucleinopathies.
FAU - Wang, Qing
AU  - Wang Q
AUID- ORCID: 0000-0002-3882-6540
AD  - Department of Neurology, Zhujiang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510282, China.
FAU - Zheng, Jialing
AU  - Zheng J
AUID- ORCID: 0000-0003-2400-7103
AD  - Department of Neurology, Zhujiang Hospital, Southern Medical University, 
      Guangzhou, Guangdong 510282, China.
FAU - Pettersson, Sven
AU  - Pettersson S
AUID- ORCID: 0000-0001-8903-3738
AD  - ASEAN Microbiome Nutrition Centre, National Neuroscience Institute, Singapore 
      308433, Singapore.
AD  - Karolinska Institutet, Department of Odontology, 171 77 Solna, Sweden.
AD  - Faculty of Medical Sciences, Sunway University, Subang Jaya, 47500 Selangor, 
      Malaysia.
AD  - Department of Microbiology and Immunology, National University Singapore, 
      Singapore 117545, Singapore.
FAU - Reynolds, Richard
AU  - Reynolds R
AUID- ORCID: 0000-0003-4622-4694
AD  - Department of Brain Sciences, Imperial College London, Hammersmith Hospital 
      Campus, Burlington Danes Building, Du Cane Road, London W12 0NN, UK.
AD  - Centre for Molecular Neuropathology, Lee Kong Chian School of Medicine, Nanyang 
      Technological University, Singapore 308232, Singapore.
FAU - Tan, Eng-King
AU  - Tan EK
AUID- ORCID: 0000-0001-9928-4805
AD  - Department of Neurology, National Neuroscience Institute, Singapore General 
      Hospital, Duke-NUS Medical School, Singapore, Singapore.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230215
PL  - United States
TA  - Sci Adv
JT  - Science advances
JID - 101653440
RN  - 0 (alpha-Synuclein)
SB  - IM
MH  - Humans
MH  - alpha-Synuclein
MH  - *Synucleinopathies/pathology
MH  - Neuroinflammatory Diseases
MH  - *Parkinson Disease/pathology
MH  - Neurons/pathology
PMC - PMC9931221
EDAT- 2023/02/16 06:00
MHDA- 2023/02/18 06:00
PMCR- 2023/02/15
CRDT- 2023/02/15 14:03
PHST- 2023/02/15 14:03 [entrez]
PHST- 2023/02/16 06:00 [pubmed]
PHST- 2023/02/18 06:00 [medline]
PHST- 2023/02/15 00:00 [pmc-release]
AID - abq1141 [pii]
AID - 10.1126/sciadv.abq1141 [doi]
PST - ppublish
SO  - Sci Adv. 2023 Feb 15;9(7):eabq1141. doi: 10.1126/sciadv.abq1141. Epub 2023 Feb 
      15.