PMID- 36792786
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230218
IS  - 2191-219X (Print)
IS  - 2191-219X (Electronic)
IS  - 2191-219X (Linking)
VI  - 13
IP  - 1
DP  - 2023 Feb 15
TI  - [(18)F] FDG uptake in patients with spondyloarthritis: correlation with serum 
      inflammatory biomarker levels.
PG  - 15
LID - 10.1186/s13550-023-00964-9 [doi]
LID - 15
AB  - BACKGROUND: We aimed to evaluate the correlation between 
      2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) uptake and disease activity assessed by 
      serum inflammatory biomarker levels in patients with spondyloarthritis (SpA). 
      METHODS: A total of 36 SpA patients (24 untreated and 12 treated) were examined 
      using FDG positron emission tomography (PET)/computed tomography and classified 
      into axial SpA (axSpA) and peripheral SpA (pSpA). FDG uptake was evaluated in 23 
      regions of the body and scored as follows: 0 = less than liver uptake; 1 = more 
      than or equal to liver uptake; and 2 = more than or equal to twice liver uptake. 
      A score of 1 or 2 was considered positive. The number of positive regions and the 
      total score were counted in each patient. The maximum standardized uptake value 
      (SUVmax) was calculated for each region, and maximum SUVmax (MaxSUVmax) was used 
      as a representative value. Correlation of PET findings with serum inflammatory 
      biomarker levels, including C-reactive protein (CRP), erythrocyte sedimentation 
      rate, and matrix metalloproteinase 3 (MMP-3), was analyzed. RESULTS: All but two 
      patients had at least one positive lesion. PET indices correlated significantly 
      with most of the serum inflammatory biomarker levels in untreated SpA, but not in 
      treated SpA. Further, MaxSUVmax, number of positive regions, and total score 
      correlated significantly with CRP (all P values < 0.001), and the number of 
      positive regions (P = 0.012) and total score (P = 0.007) correlated significantly 
      with MMP-3 in untreated pSpA. PET indices did not correlate with any serum 
      inflammatory biomarker level in untreated axSpA. CONCLUSION: FDG uptake in 
      untreated pSpA correlated significantly with serum inflammatory biomarker levels.
CI  - (c) 2023. The Author(s).
FAU - Manabe, Yuri
AU  - Manabe Y
AUID- ORCID: 0000-0002-5286-157X
AD  - Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, 
      Miki-cho, Kita-gun, Kagawa, 761-0793, Japan. manabe.yuri@kagawa-u.ac.jp.
FAU - Norikane, Takashi
AU  - Norikane T
AD  - Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, 
      Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
FAU - Yamamoto, Yuka
AU  - Yamamoto Y
AD  - Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, 
      Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
FAU - Murao, Mitsumasa
AU  - Murao M
AD  - Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, 
      Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
FAU - Shimada, Hiromi
AU  - Shimada H
AD  - Division of Hematology, Rheumatology and Respiratory Medicine, Department of 
      Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.
FAU - Wakiya, Risa
AU  - Wakiya R
AD  - Division of Hematology, Rheumatology and Respiratory Medicine, Department of 
      Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.
FAU - Nakashima, Shusaku
AU  - Nakashima S
AD  - Division of Hematology, Rheumatology and Respiratory Medicine, Department of 
      Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.
FAU - Dobashi, Hiroaki
AU  - Dobashi H
AD  - Division of Hematology, Rheumatology and Respiratory Medicine, Department of 
      Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.
FAU - Nishiyama, Yoshihiro
AU  - Nishiyama Y
AD  - Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, 
      Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
LA  - eng
PT  - Journal Article
DEP - 20230215
PL  - Germany
TA  - EJNMMI Res
JT  - EJNMMI research
JID - 101560946
PMC - PMC9931986
OTO - NOTNLM
OT  - CRP
OT  - FDG
OT  - MMP-3
OT  - PET
OT  - Spondyloarthritis
COIS- The authors declare that they have no competing interests.
EDAT- 2023/02/16 06:00
MHDA- 2023/02/16 06:01
PMCR- 2023/02/15
CRDT- 2023/02/15 23:25
PHST- 2022/12/14 00:00 [received]
PHST- 2023/02/05 00:00 [accepted]
PHST- 2023/02/15 23:25 [entrez]
PHST- 2023/02/16 06:00 [pubmed]
PHST- 2023/02/16 06:01 [medline]
PHST- 2023/02/15 00:00 [pmc-release]
AID - 10.1186/s13550-023-00964-9 [pii]
AID - 964 [pii]
AID - 10.1186/s13550-023-00964-9 [doi]
PST - epublish
SO  - EJNMMI Res. 2023 Feb 15;13(1):15. doi: 10.1186/s13550-023-00964-9.