PMID- 36793325
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230217
IS  - 2190-4286 (Print)
IS  - 2190-4286 (Electronic)
IS  - 2190-4286 (Linking)
VI  - 14
DP  - 2023
TI  - Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery 
      systems.
PG  - 218-232
LID - 10.3762/bjnano.14.21 [doi]
AB  - Cyclodextrins have been widely employed for drug delivery systems (DDSs) in which 
      drugs are selectively delivered to a target site in the body. Recent interest has 
      been focused on the construction of cyclodextrin-based nanoarchitectures that 
      show sophisticated DDS functions. These nanoarchitectures are precisely 
      fabricated based on three important features of cyclodextrins, namely (1) the 
      preorganized three-dimensional molecular structure of nanometer size, (2) the 
      easy chemical modification to introduce functional groups, and (3) the formation 
      of dynamic inclusion complexes with various guests in water. With the use of 
      photoirradiation, drugs are released from cyclodextrin-based nanoarchitectures at 
      designated timing. Alternatively, therapeutic nucleic acids are stably protected 
      in the nanoarchitectures and delivered to the target site. The efficient delivery 
      of the CRISPR-Cas9 system for gene editing was also successful. Even more 
      complicated nanoarchitectures can be designed for sophisticated DDSs. 
      Cyclodextrin-based nanoarchitectures are highly promising for future applications 
      in medicine, pharmaceutics, and other relevant fields.
CI  - Copyright (c) 2023, Komiyama.
FAU - Komiyama, Makoto
AU  - Komiyama M
AUID- ORCID: 0000-0002-9381-1018
AD  - Research Center for Advanced Science and Technology (RCAST), The University of 
      Tokyo, 4-6-1 Komaba, Meguro, Tokyo 153-8904, Japan. ROR: 
      https://ror.org/057zh3y96. ISNI: https://www.isni.org/isni/000000012151536X
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230209
PL  - Germany
TA  - Beilstein J Nanotechnol
JT  - Beilstein journal of nanotechnology
JID - 101551563
PMC - PMC9924364
OTO - NOTNLM
OT  - cyclodextrin
OT  - drug delivery system (DDS)
OT  - nanoarchitecture
OT  - phototherapy
OT  - siRNA
EDAT- 2023/02/17 06:00
MHDA- 2023/02/17 06:01
PMCR- 2023/02/09
CRDT- 2023/02/16 02:14
PHST- 2022/11/05 00:00 [received]
PHST- 2023/01/26 00:00 [accepted]
PHST- 2023/02/16 02:14 [entrez]
PHST- 2023/02/17 06:00 [pubmed]
PHST- 2023/02/17 06:01 [medline]
PHST- 2023/02/09 00:00 [pmc-release]
AID - 10.3762/bjnano.14.21 [doi]
PST - epublish
SO  - Beilstein J Nanotechnol. 2023 Feb 9;14:218-232. doi: 10.3762/bjnano.14.21. 
      eCollection 2023.