PMID- 36794231
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230217
IS  - 2297-1769 (Print)
IS  - 2297-1769 (Electronic)
IS  - 2297-1769 (Linking)
VI  - 9
DP  - 2022
TI  - Pharmacokinetic and pharmacodynamic properties of pantoprazole in calves.
PG  - 1101461
LID - 10.3389/fvets.2022.1101461 [doi]
LID - 1101461
AB  - INTRODUCTION: Development of abomasal ulceration is a large concern, especially 
      within calves; however, there is a paucity of research into the use of gastro 
      protectants in ruminant species. Proton pump inhibitors, such as pantoprazole, 
      are widely used in humans and companion animals. Their efficacy in ruminant 
      species is undetermined. The objectives of this study were to 1) estimate the 
      plasma pharmacokinetic parameters for pantoprazole in neonatal calves after three 
      days of intravenous (IV) or subcutaneous (SC) administration, and 2) measure the 
      effect pantoprazole had on abomasal pH over the treatment period. METHODS: 
      Pantoprazole was administered to 6 Holstein-Angus cross bull calves at a dose of 
      1 mg/kg (IV) or 2 mg/kg (SC), once a day (every 24 h) for three days. Plasma 
      samples were collected over a 72 h period and analyzed via HPLC-UV for 
      determining pantoprazole concentrations. Pharmacokinetic parameters were derived 
      via non-compartmental analysis. Abomasal (n= 8) samples were collected via 
      abomasal cannulas over a 12 h period, per calf per day. Abomasal pH was 
      determined via a bench top pH analyzer. RESULTS: Following Day 1 of IV 
      administration, plasma clearance, elimination half-life, and volume of 
      distribution of pantoprazole were estimated at 199.9 mL/kg/h, 1.44 h, and 0.51 
      L/kg, respectively. On Day 3 of IV administration, the reported values were 192.9 
      mL/kg/h, 2.52 h, and 1.80 L/kg mL, respectively. Elimination half-life and volume 
      of distribution (V/F) of pantoprazole following SC administration were estimated 
      at 1.81 h and 0.55 L/kg, respectively, on Day 1; and 2.99 h and 2.82 L/kg, 
      respectively, on Day 3. DISCUSSION: The reported values for IV administration 
      were similar to those previously reported in calves. SC administration appears to 
      be well absorbed and tolerated. The sulfone metabolite was detectable for 36 h 
      after the last administration for both routes. Abomasal pH was significantly 
      higher than the pre-pantoprazole pH 4, 6, and 8 h after administration in both 
      the IV and SC groups. Further studies of pantoprazole as a treatment/preventative 
      for abomasal ulcers are warranted.
CI  - Copyright (c) 2023 Olivarez, Mulon, Ebner, Cremerius, Cantrell, Rahn, 
      Soto-Gonzalez, Bergman, Cox, Mochel, Kreuder and Smith.
FAU - Olivarez, Jeff D
AU  - Olivarez JD
AD  - Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, 
      IA, United States.
FAU - Mulon, Pierre-Yves
AU  - Mulon PY
AD  - Large Animal Clinical Sciences, College of Veterinary Medicine, University of 
      Tennessee, Knoxville, Knoxville, TN, United States.
FAU - Ebner, Lisa S
AU  - Ebner LS
AD  - College of Veterinary Medicine, Lincoln Memorial University, Harrogate, TN, 
      United States.
FAU - Cremerius, Haley
AU  - Cremerius H
AD  - Large Animal Clinical Sciences, College of Veterinary Medicine, University of 
      Tennessee, Knoxville, Knoxville, TN, United States.
FAU - Cantrell, Channing
AU  - Cantrell C
AD  - Large Animal Clinical Sciences, College of Veterinary Medicine, University of 
      Tennessee, Knoxville, Knoxville, TN, United States.
FAU - Rahn, Rebecca
AU  - Rahn R
AD  - Large Animal Clinical Sciences, College of Veterinary Medicine, University of 
      Tennessee, Knoxville, Knoxville, TN, United States.
FAU - Soto-Gonzalez, Windy
AU  - Soto-Gonzalez W
AD  - Large Animal Clinical Sciences, College of Veterinary Medicine, University of 
      Tennessee, Knoxville, Knoxville, TN, United States.
FAU - Bergman, Joan
AU  - Bergman J
AD  - Biomedical and Diagnostic Sciences, University of Tennessee, Knoxville, 
      Knoxville, TN, United States.
FAU - Cox, Sherry
AU  - Cox S
AD  - Biomedical and Diagnostic Sciences, University of Tennessee, Knoxville, 
      Knoxville, TN, United States.
FAU - Mochel, Jonathan P
AU  - Mochel JP
AD  - Veterinary Diagnostic and Production Animal Medicine, College of Veterinary 
      Medicine, Iowa State University, Ames, IA, United States.
FAU - Kreuder, Amanda J
AU  - Kreuder AJ
AD  - Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, 
      Iowa State University, Ames, IA, United States.
FAU - Smith, Joe S
AU  - Smith JS
AD  - Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, 
      IA, United States.
AD  - Large Animal Clinical Sciences, College of Veterinary Medicine, University of 
      Tennessee, Knoxville, Knoxville, TN, United States.
LA  - eng
PT  - Journal Article
DEP - 20230130
PL  - Switzerland
TA  - Front Vet Sci
JT  - Frontiers in veterinary science
JID - 101666658
PMC - PMC9923100
OTO - NOTNLM
OT  - abomasum
OT  - bovine
OT  - cattle
OT  - proton pump inhibitor
OT  - ulcer
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/02/17 06:00
MHDA- 2023/02/17 06:01
PMCR- 2022/01/01
CRDT- 2023/02/16 02:28
PHST- 2022/11/17 00:00 [received]
PHST- 2022/12/29 00:00 [accepted]
PHST- 2023/02/16 02:28 [entrez]
PHST- 2023/02/17 06:00 [pubmed]
PHST- 2023/02/17 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fvets.2022.1101461 [doi]
PST - epublish
SO  - Front Vet Sci. 2023 Jan 30;9:1101461. doi: 10.3389/fvets.2022.1101461. 
      eCollection 2022.