PMID- 36794867
OWN - NLM
STAT- MEDLINE
DCOM- 20230710
LR  - 20240409
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 213
IP  - 1
DP  - 2023 Jul 5
TI  - Features of BAFF and APRIL receptors on circulating B cells in antineutrophil 
      cytoplasmic antibody-associated vasculitis.
PG  - 125-137
LID - 10.1093/cei/uxad024 [doi]
AB  - To investigate the features of circulating B cells, their expressing receptors, 
      serum levels of B-cell activation factor of the TNF family (BAFF), and a 
      proliferation-inducing ligand (APRIL) in antineutrophil cytoplasmic 
      antibody-associated vasculitis (AAV). Blood samples from 24 patients with active 
      AAV (a-AAV), 13 with inactive AAV (i-AAV), and 19 healthy controls (HC) were 
      included in this study. The proportion of B cells and their expressing BAFF 
      receptor (BAFF-R), transmembrane activator and calcium modulator and cyclophilin 
      ligand interactor (TACI), and B-cell maturation antigen were analyzed via flow 
      cytometry. Serum levels of BAFF, APRIL, and interleukin (IL)-4, IL-6, IL-10, and 
      IL-13 were also evaluated using an enzyme-linked immunosorbent assay. The 
      proportion of plasmablasts (PB)/plasma cells (PC) and serum levels of BAFF, 
      APRIL, IL-4, and IL-6 were significantly higher in a-AAV than in HC. Higher serum 
      levels of BAFF, APRIL, and IL-4 were observed in i-AAV than in HC. Lower 
      expression of BAFF-R on memory B cells and higher expression of TACI on CD19+ 
      cells, immature B cells, and PB/PC were demonstrated in a-AAV and i-AAV than in 
      HC. The population of memory B cells was positively associated with serum APRIL 
      levels and BAFF-R expression in a-AAV. In conclusion, decreased expression of 
      BAFF-R on memory B cells and increased expression of TACI on CD19+ cells, 
      immature B cells, and PB/PC, as well as increased serum levels of BAFF and APRIL, 
      were sustained even in the remission phase of AAV. Persistent aberrant signaling 
      of BAFF/APRIL may contribute to disease relapse.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      British Society for Immunology. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Shimojima, Yasuhiro
AU  - Shimojima Y
AUID- ORCID: 0000-0001-7100-1121
AD  - Department of Medicine (Neurology and Rheumatology), Shinshu University School of 
      Medicine, Matsumoto, Japan.
FAU - Kishida, Dai
AU  - Kishida D
AD  - Department of Medicine (Neurology and Rheumatology), Shinshu University School of 
      Medicine, Matsumoto, Japan.
FAU - Ichikawa, Takanori
AU  - Ichikawa T
AD  - Department of Medicine (Neurology and Rheumatology), Shinshu University School of 
      Medicine, Matsumoto, Japan.
FAU - Takamatsu, Ryota
AU  - Takamatsu R
AD  - Department of Medicine (Neurology and Rheumatology), Shinshu University School of 
      Medicine, Matsumoto, Japan.
FAU - Nomura, Shun
AU  - Nomura S
AD  - Department of Medicine (Neurology and Rheumatology), Shinshu University School of 
      Medicine, Matsumoto, Japan.
FAU - Sekijima, Yoshiki
AU  - Sekijima Y
AD  - Department of Medicine (Neurology and Rheumatology), Shinshu University School of 
      Medicine, Matsumoto, Japan.
LA  - eng
GR  - JP21K08455/KAKENHI/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 207137-56-2 (Interleukin-4)
RN  - 0 (TNFSF13 protein, human)
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor Ligand Superfamily Member 13)
RN  - 0 (B-Cell Activating Factor)
RN  - 0 (B-Cell Activation Factor Receptor)
SB  - IM
MH  - Humans
MH  - *Interleukin-4
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Interleukin-6
MH  - Tumor Necrosis Factor Ligand Superfamily Member 13/metabolism
MH  - B-Cell Activating Factor
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
MH  - B-Cell Activation Factor Receptor
PMC - PMC10324548
OTO - NOTNLM
OT  - ANCA-associated vasculitis
OT  - APRIL
OT  - B-cell subsets
OT  - BAFF
OT  - BAFF-R
OT  - TACI
COIS- The authors declare that they have no financial or personal conflicts of interest
EDAT- 2023/02/17 06:00
MHDA- 2023/07/10 06:42
PMCR- 2024/02/16
CRDT- 2023/02/16 08:32
PHST- 2022/09/27 00:00 [received]
PHST- 2023/02/11 00:00 [revised]
PHST- 2023/02/15 00:00 [accepted]
PHST- 2023/07/10 06:42 [medline]
PHST- 2023/02/17 06:00 [pubmed]
PHST- 2023/02/16 08:32 [entrez]
PHST- 2024/02/16 00:00 [pmc-release]
AID - 7043033 [pii]
AID - uxad024 [pii]
AID - 10.1093/cei/uxad024 [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2023 Jul 5;213(1):125-137. doi: 10.1093/cei/uxad024.