PMID- 36796338
OWN - NLM
STAT- MEDLINE
DCOM- 20230405
LR  - 20230405
IS  - 1423-0224 (Electronic)
IS  - 0302-282X (Linking)
VI  - 82
IP  - 2
DP  - 2023
TI  - Changes in Inflammatory Markers in Clinical High Risk of Developing Psychosis.
PG  - 104-116
LID - 10.1159/000528770 [doi]
AB  - INTRODUCTION: Immune alterations are associated with the progression of 
      psychosis. However, there are few studies designed to longitudinally measure 
      inflammatory biomarkers during psychotic episodes. We aimed to assess changes in 
      biomarkers from the prodromal phase to psychotic episodes in individuals with 
      clinical high risk (CHR) of psychosis and compare converters and non-converters 
      to psychosis as well as healthy controls (HCs). METHODS: We enrolled 394 
      individuals with CHR and 100 HCs. A total of 263 individuals with CHR completed 
      the 1-year follow-up, and 47 had converted to psychosis. Interleukin (IL)-1beta, 2, 
      6, 8, 10, tumor necrosis factor-alpha (TNF-alpha), and vascular endothelial growth factor 
      levels were measured at baseline and 1 year after completion of the clinical 
      assessment. RESULTS: The baseline serum levels of IL-10, IL-2, and IL-6 were 
      significantly lower in the conversion group than in the non-conversion group 
      (IL-10, p = 0.010; IL-2, p = 0.023; IL-6, p = 0.012) and HC (IL-6: p = 0.034). 
      Self-controlled comparisons showed that IL-2 changed significantly (p = 0.028), 
      and IL-6 levels tended toward significance (p = 0.088) in the conversion group. 
      In the non-conversion group, serum levels of TNF-alpha (p = 0.017) and VEGF (p = 
      0.037) changed significantly. Repeated measures analysis of variance revealed a 
      significant time effect related to TNF-alpha (F = 4.502, p = 0.037, effect size (eta2) 
      = 0.051), a group effect related to IL-1beta (F = 4.590, p = 0.036, eta2 = 0.062), and 
      IL-2 (F = 7.521, p = 0.011, eta2 = 0.212), but no time x group effect. DISCUSSION: 
      Alterations in the serum levels of inflammatory cytokines were found to precede 
      the first episode of psychosis in the CHR population, particularly for those who 
      later converted to psychosis. Longitudinal analysis supports the varied roles of 
      cytokines in individuals with CHR with later psychotic conversion or 
      non-conversion outcomes.
CI  - (c) 2023 S. Karger AG, Basel.
FAU - Zhang, TianHong
AU  - Zhang T
AD  - Shanghai Mental Health Center, Shanghai Intelligent Psychological Evaluation and 
      Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key 
      Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of 
      Medicine, Shanghai, China.
FAU - Zeng, JiaHui
AU  - Zeng J
AD  - Shanghai Mental Health Center, Shanghai Intelligent Psychological Evaluation and 
      Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key 
      Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of 
      Medicine, Shanghai, China.
FAU - Wei, YanYan
AU  - Wei Y
AD  - Shanghai Mental Health Center, Shanghai Intelligent Psychological Evaluation and 
      Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key 
      Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of 
      Medicine, Shanghai, China.
FAU - Ye, JiaYi
AU  - Ye J
AD  - Shanghai Mental Health Center, Shanghai Intelligent Psychological Evaluation and 
      Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key 
      Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of 
      Medicine, Shanghai, China.
FAU - Tang, XiaoChen
AU  - Tang X
AD  - Shanghai Mental Health Center, Shanghai Intelligent Psychological Evaluation and 
      Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key 
      Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of 
      Medicine, Shanghai, China.
FAU - Xu, LiHua
AU  - Xu L
AD  - Shanghai Mental Health Center, Shanghai Intelligent Psychological Evaluation and 
      Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key 
      Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of 
      Medicine, Shanghai, China.
FAU - Hu, YeGang
AU  - Hu Y
AD  - Shanghai Mental Health Center, Shanghai Intelligent Psychological Evaluation and 
      Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key 
      Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of 
      Medicine, Shanghai, China.
FAU - Liu, HaiChun
AU  - Liu H
AD  - Department of Automation, Shanghai Jiao Tong University, Shanghai, China.
FAU - Chen, Tao
AU  - Chen T
AD  - Big Data Research Lab, University of Waterloo, Waterloo, Ontario, Canada.
AD  - Labor and Worklife Program, Harvard University, Cambridge, Massachusetts, USA.
FAU - Li, ChunBo
AU  - Li C
AD  - Shanghai Mental Health Center, Shanghai Intelligent Psychological Evaluation and 
      Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key 
      Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of 
      Medicine, Shanghai, China.
FAU - Wang, JiJun
AU  - Wang J
AD  - Shanghai Mental Health Center, Shanghai Intelligent Psychological Evaluation and 
      Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key 
      Laboratory of Psychotic Disorders, Shanghai Jiaotong University School of 
      Medicine, Shanghai, China.
AD  - Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), 
      Chinese Academy of Science, Shanghai, China.
AD  - Institute of Psychology and Behavioral Science, Shanghai Jiao Tong University, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20230216
PL  - Switzerland
TA  - Neuropsychobiology
JT  - Neuropsychobiology
JID - 7512895
RN  - 130068-27-8 (Interleukin-10)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Interleukin-2)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Cytokines)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - *Interleukin-10
MH  - Interleukin-6
MH  - Tumor Necrosis Factor-alpha
MH  - Interleukin-2
MH  - Vascular Endothelial Growth Factor A
MH  - Longitudinal Studies
MH  - *Psychotic Disorders/epidemiology
MH  - Cytokines
MH  - Biomarkers
OTO - NOTNLM
OT  - Cytokine
OT  - Inflammatory markers
OT  - Interleukin
OT  - Transition
OT  - Ultra-high risk
EDAT- 2023/02/17 06:00
MHDA- 2023/04/05 06:42
CRDT- 2023/02/16 18:22
PHST- 2022/10/22 00:00 [received]
PHST- 2022/12/12 00:00 [accepted]
PHST- 2023/04/05 06:42 [medline]
PHST- 2023/02/17 06:00 [pubmed]
PHST- 2023/02/16 18:22 [entrez]
AID - 000528770 [pii]
AID - 10.1159/000528770 [doi]
PST - ppublish
SO  - Neuropsychobiology. 2023;82(2):104-116. doi: 10.1159/000528770. Epub 2023 Feb 16.