PMID- 36796639
OWN - NLM
STAT- MEDLINE
DCOM- 20230328
LR  - 20230328
IS  - 2468-7847 (Electronic)
IS  - 2468-7847 (Linking)
VI  - 52
IP  - 4
DP  - 2023 Apr
TI  - Contribution of amniocentesis in fetuses small for gestational age without other 
      sonographic signs.
PG  - 102552
LID - S2468-7847(23)00019-3 [pii]
LID - 10.1016/j.jogoh.2023.102552 [doi]
AB  - OBJECTIVE: Our study evaluated the contribution of amniocentesis in the 
      diagnostic approach of small-for-gestational-age fetuses (SGA) without 
      morphological abnormality identified on ultrasound by studying FISH (fluorescence 
      in situ hybridization) for chromosomes 13, 18 and 21, CMV PCR (cytomegalovirus 
      polymerase chain reaction), karyotype and CGH (genomic hybridization array) 
      METHODS: Our single-center retrospective cohort study included pregnant women 
      referred for prenatal diagnosis for a SGA fetus in whom amniocentesis was 
      performed between 2016 and 2019. A SGA fetus was defined as a fetus with an 
      estimated fetal weight (EFW) below the 10th percentile according to referral 
      growth curves in use. We evaluated the number of amniocenteses with an abnormal 
      result and identified factors that may be associated with this outcome. RESULTS: 
      Among the 79 amniocenteses performed, there were 5 (6.3%) abnormalities: 
      karyotype (1.3%) and CGH (5.1%). No complications were described. We did not find 
      any statistically significant factors associated with abnormal amniocentesis 
      findings even if some elements seemed reassuring such as late discovery 
      (p = 0.31), moderate SGA (p = 0.18), normal head, abdomen and femur measurements 
      (p = 0.57), but without statistically significant difference. CONCLUSION: Our 
      study found 6.3% pathological analysis of amniocenteses, of which several would 
      have been missed by conventional karyotyping. Patients must be informed about the 
      risk of detecting abnormalities of low severity, with low penetrance or with 
      unknown fetal consequences that could be source of anxiety.
CI  - Copyright (c) 2023 Elsevier Masson SAS. All rights reserved.
FAU - Labaye, Solene
AU  - Labaye S
AD  - Assistance Publique-Hopitaux de Paris, Service de Gynecologie-Obstetrique, 
      Hopital Louis Mourier, Colombes, France.
FAU - Peyronnet, Violaine
AU  - Peyronnet V
AD  - Assistance Publique-Hopitaux de Paris, Service de Gynecologie-Obstetrique, 
      Hopital Louis Mourier, Colombes, France; Universite de Paris Cite, Paris, France. 
      Electronic address: violaine.peyronnet@aphp.fr.
FAU - Coussement, Aurelie
AU  - Coussement A
AD  - Universite de Paris Cite, Paris, France; Assistance Publique-Hopitaux de Paris, 
      Service de Cytogenetique, Hopital Cochin, Paris, France.
FAU - Mandelbrot, Laurent
AU  - Mandelbrot L
AD  - Assistance Publique-Hopitaux de Paris, Service de Gynecologie-Obstetrique, 
      Hopital Louis Mourier, Colombes, France; Universite de Paris Cite, Paris, France; 
      Inserm IAME 1137 Infection . Antimicrobials. Modelling. Evolution.
FAU - Picone, Olivier
AU  - Picone O
AD  - Assistance Publique-Hopitaux de Paris, Service de Gynecologie-Obstetrique, 
      Hopital Louis Mourier, Colombes, France; Universite de Paris Cite, Paris, France; 
      Inserm IAME 1137 Infection . Antimicrobials. Modelling. Evolution.
LA  - eng
PT  - Journal Article
DEP - 20230215
PL  - France
TA  - J Gynecol Obstet Hum Reprod
JT  - Journal of gynecology obstetrics and human reproduction
JID - 101701588
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - *Amniocentesis
MH  - Gestational Age
MH  - Retrospective Studies
MH  - In Situ Hybridization, Fluorescence
MH  - Fetal Growth Retardation
MH  - Fetus
MH  - *Infant, Newborn, Diseases
OTO - NOTNLM
OT  - Amniocentesis
OT  - Comparative genomic hybridization array
OT  - Intrauterine growth restriction
OT  - Prenatal diagnosis
OT  - Small for gestational age
COIS- Declaration of Competing Interest The authors declare that they have no competing 
      interest.
EDAT- 2023/02/17 06:00
MHDA- 2023/03/28 17:14
CRDT- 2023/02/16 19:27
PHST- 2022/11/17 00:00 [received]
PHST- 2023/01/23 00:00 [revised]
PHST- 2023/02/12 00:00 [accepted]
PHST- 2023/03/28 17:14 [medline]
PHST- 2023/02/17 06:00 [pubmed]
PHST- 2023/02/16 19:27 [entrez]
AID - S2468-7847(23)00019-3 [pii]
AID - 10.1016/j.jogoh.2023.102552 [doi]
PST - ppublish
SO  - J Gynecol Obstet Hum Reprod. 2023 Apr;52(4):102552. doi: 
      10.1016/j.jogoh.2023.102552. Epub 2023 Feb 15.