PMID- 36798908
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230218
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 16
DP  - 2023
TI  - Correlation Between Mean Amplitude of Glycemic Excursion and Bone Turnover 
      Markers in Patients with Type 2 Diabetes: A Cross-Sectional Study.
PG  - 397-407
LID - 10.2147/DMSO.S388919 [doi]
AB  - OBJECTIVE: The present study explores the relationship between glycemic excursion 
      and bone turnover markers. METHODS: A total of 250 patients with type 2 diabetes 
      mellitus (T2DM) (142 female and 108 male patients) were enrolled in this study. 
      All participants underwent 72 hours of continuous glycemic monitoring to evaluate 
      the mean amplitude of glycemic excursions (MAGE) of each person. Bone turnover 
      markers and other biochemical data were measured for each patient. Linear 
      regression was performed to explore the relationship between bone turnover 
      markers and glycemic excursion. A value of P < 0.05 was considered statistically 
      significant. RESULTS: MAGE was negatively correlated to N-terminal propeptide of 
      type 1 collagen (P1NP) female: [odds ratios (95% confidence interval) (OR (95% 
      CI)), -2.516 (-5.389, 0.356)]; male: [-2.895, (-6.521, -0.731)] and C-terminal 
      telopeptide fragments of type-I collagen (beta-CTX) female [-0.025, (-0.036, 
      0.005)]; male [-0.043, (-0.082, 0.003)]. MAGE was still negatively correlated 
      with beta-CTX female [-0.036, (-0.198, -0.030)]; male [-0.048, (-0.089, -0.007)] 
      after adjusting for clinical data and biochemical indices. CONCLUSION: An 
      independent negative relationship between glycemic excursion and bone turnover 
      markers in patients with T2DM was identified in this study.
CI  - (c) 2023 Yang et al.
FAU - Yang, Jiamiao
AU  - Yang J
AD  - Department of Endocrinology, Shanghai Punan Hospital of Pudong New District, 
      Shanghai, People's Republic of China.
FAU - Zheng, Chao
AU  - Zheng C
AD  - Department of Endocrinology, Shanghai Punan Hospital of Pudong New District, 
      Shanghai, People's Republic of China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Endocrinology, Shanghai Punan Hospital of Pudong New District, 
      Shanghai, People's Republic of China.
FAU - Yang, Ling
AU  - Yang L
AD  - Department of Endocrinology, Shanghai Punan Hospital of Pudong New District, 
      Shanghai, People's Republic of China.
FAU - Liu, Lianyong
AU  - Liu L
AD  - Department of Endocrinology, Shanghai Punan Hospital of Pudong New District, 
      Shanghai, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20230210
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC9926982
OTO - NOTNLM
OT  - bone turnover markers
OT  - continuous glucose monitoring
OT  - glycemic variability
OT  - mean amplitude of glycemic excursions
OT  - type 2 diabetes mellitus
COIS- The authors report no conflicts of interest in this work.
EDAT- 2023/02/18 06:00
MHDA- 2023/02/18 06:01
PMCR- 2023/02/10
CRDT- 2023/02/17 02:18
PHST- 2022/09/09 00:00 [received]
PHST- 2023/01/13 00:00 [accepted]
PHST- 2023/02/17 02:18 [entrez]
PHST- 2023/02/18 06:00 [pubmed]
PHST- 2023/02/18 06:01 [medline]
PHST- 2023/02/10 00:00 [pmc-release]
AID - 388919 [pii]
AID - 10.2147/DMSO.S388919 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2023 Feb 10;16:397-407. doi: 10.2147/DMSO.S388919. 
      eCollection 2023.