PMID- 36798918
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230218
IS  - 2277-9175 (Print)
IS  - 2277-9175 (Electronic)
IS  - 2277-9175 (Linking)
VI  - 11
DP  - 2022
TI  - Association of Subclinical Hypothyroidism with Nonalcoholic Fatty Liver Disease 
      in Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study.
PG  - 124
LID - 10.4103/abr.abr_15_21 [doi]
LID - 124
AB  - BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus 
      (T2DM) are recognized as two common health problems. Metabolic diseases, such as 
      dyslipidemia, obesity, and hypertension are known risk factors for NAFLD. In 
      addition to these risk factors, other risk factors have been recently suggested, 
      such as thyroid dysfunction. MATERIALS AND METHODS: In this study, adult patients 
      with T2DM were recruited. Various clinical and biochemical parameters including 
      thyroid function tests, liver function tests, and liver sonography in all 
      participants were assessed and compared between with and without NAFLD groups. 
      RESULTS: Data from 926 diabetic patients were analyzed; of which, 744 (80.3%) had 
      fatty liver. The prevalence of subclinical hypothyroidism (SCH) in patients with 
      NAFLD was 11.6% and in patients without NAFLD was 6.0% (P = 0.029). Furthermore, 
      the prevalence of overt hypothyroidism was higher in diabetic patients with NAFLD 
      (3.9% vs. 1.6%); this difference was not statistically significant. In univariate 
      logistic regression analysis, hemoglobin A1c (odds ratio [OR]: 8.13); history of 
      insulin consumption (OR: 5.35); duration of diabetes (OR: 2.20); family history 
      of diabetes (OR: 2.85); history of antihypertensive drug use (OR: 2.14) as well 
      as SCH (OR: 2.03) were significant variables for NAFLD. According to the 
      multivariate logistic model, after eliminating the confounding effect of age, 
      sex, and body mass index; the chance of developing NAFLD in patients with SCH was 
      2.32 times higher than patients without SCH (P = 0.014). CONCLUSION: NAFLD is 
      extremely common in patients with T2DM. The relationship between hypothyroidism 
      and NAFLD is independent of other risk factors.
CI  - Copyright: (c) 2022 Advanced Biomedical Research.
FAU - Sheikhi, Vahid
AU  - Sheikhi V
AD  - Department of Pediatric Nephrology, Zahedan University of Medical Sciences, 
      Zahedan, Iran.
FAU - Heidari, Zahra
AU  - Heidari Z
AD  - Department of Endocrinology and Metabolism, Zahedan University of Medical 
      Sciences, Zahedan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20221226
PL  - India
TA  - Adv Biomed Res
JT  - Advanced biomedical research
JID - 101586897
PMC - PMC9926038
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - hypothyroidism
OT  - nonalcoholic fatty liver disease
OT  - type 2
COIS- There are no conflicts of interest.
EDAT- 2023/02/18 06:00
MHDA- 2023/02/18 06:01
PMCR- 2022/12/26
CRDT- 2023/02/17 02:18
PHST- 2021/01/24 00:00 [received]
PHST- 2021/06/16 00:00 [revised]
PHST- 2021/12/08 00:00 [accepted]
PHST- 2023/02/17 02:18 [entrez]
PHST- 2023/02/18 06:00 [pubmed]
PHST- 2023/02/18 06:01 [medline]
PHST- 2022/12/26 00:00 [pmc-release]
AID - ABR-11-124 [pii]
AID - 10.4103/abr.abr_15_21 [doi]
PST - epublish
SO  - Adv Biomed Res. 2022 Dec 26;11:124. doi: 10.4103/abr.abr_15_21. eCollection 2022.