PMID- 36799652
OWN - NLM
STAT- MEDLINE
DCOM- 20230321
LR  - 20230321
IS  - 1600-0714 (Electronic)
IS  - 0904-2512 (Linking)
VI  - 52
IP  - 3
DP  - 2023 Mar
TI  - Changes in quality of life over time in patients diagnosed with oral leukoplakia: 
      A prospective longitudinal study.
PG  - 226-231
LID - 10.1111/jop.13415 [doi]
AB  - BACKGROUND: Oral leukoplakia (OL) is one of the most prevalent oral potentially 
      malignant disorders (OPMD). Although there is emerging evidence that quality of 
      life (QoL) is impaired in subjects with OL; studies to date are based on single 
      and heterogenous point-in-time assessments. The aim of this study was to 
      ascertain if QoL scores change over time in individuals diagnosed with OL. 
      METHODS: Forty-one individuals with OL were administered the Short Generic Health 
      Questionnaire (SF-12) and the discipline-specific Oral Potentially Malignant 
      Disorder Questionnaire (OPMDQ) at four points in time: at the time of clinical 
      diagnosis, at the post-biopsy review (confirmed diagnosis), and at 3- and 6-month 
      follow-up appointments. Responses were compared between the four time points. 
      RESULTS: No significant differences were observed in the SF-12 questionnaire 
      scores over time. However, a general improvement in the participants' life 
      quality was evident over the 6-month period under investigation in the domains of 
      psychological and social well-being (p = 0.0027) and effect of treatment on daily 
      life (p = 0.0317) as well as in the total score (p = 0.0005) of the OPMDQ. Age, 
      gender, medical status, tobacco/alcohol use, lesion site, size, the presence of 
      dysplasia and treatment did not impact QoL scores over time. CONCLUSIONS: QoL 
      scores of OL subjects may improve with time. Our results suggest that studies 
      examining QoL in individuals with OL should be controlled for time at which the 
      participants are surveyed.
CI  - (c) 2023 The Authors. Journal of Oral Pathology & Medicine published by John Wiley 
      & Sons Ltd.
FAU - Frydrych, Agnieszka M
AU  - Frydrych AM
AUID- ORCID: 0000-0001-5301-4148
AD  - UWA Dental School, The University of Western Australia, Nedlands, WA, Australia.
FAU - van Schaijik, Bede
AU  - van Schaijik B
AUID- ORCID: 0000-0003-1847-4936
AD  - UWA Dental School, The University of Western Australia, Nedlands, WA, Australia.
FAU - Parsons, Richard
AU  - Parsons R
AD  - Medical School, Curtin University, Bentley, WA, Australia.
FAU - Kujan, Omar
AU  - Kujan O
AUID- ORCID: 0000-0002-5951-8280
AD  - UWA Dental School, The University of Western Australia, Nedlands, WA, Australia.
LA  - eng
PT  - Journal Article
DEP - 20230228
PL  - Denmark
TA  - J Oral Pathol Med
JT  - Journal of oral pathology & medicine : official publication of the International 
      Association of Oral Pathologists and the American Academy of Oral Pathology
JID - 8911934
SB  - IM
MH  - Humans
MH  - *Quality of Life
MH  - Prospective Studies
MH  - Longitudinal Studies
MH  - Leukoplakia, Oral/pathology
MH  - *Mouth Diseases
OTO - NOTNLM
OT  - change
OT  - longitudinal study
OT  - oral leukoplakia
OT  - oral potentially malignant disorder
OT  - quality of life
EDAT- 2023/02/18 06:00
MHDA- 2023/03/22 06:00
CRDT- 2023/02/17 09:04
PHST- 2022/12/07 00:00 [revised]
PHST- 2022/11/13 00:00 [received]
PHST- 2023/02/15 00:00 [accepted]
PHST- 2023/02/18 06:00 [pubmed]
PHST- 2023/03/22 06:00 [medline]
PHST- 2023/02/17 09:04 [entrez]
AID - 10.1111/jop.13415 [doi]
PST - ppublish
SO  - J Oral Pathol Med. 2023 Mar;52(3):226-231. doi: 10.1111/jop.13415. Epub 2023 Feb 
      28.