PMID- 36801127
OWN - NLM
STAT- MEDLINE
DCOM- 20230424
LR  - 20230424
IS  - 1444-2892 (Electronic)
IS  - 1443-9506 (Linking)
VI  - 32
IP  - 4
DP  - 2023 Apr
TI  - Trends in Modifiable Risk Factors Amongst First Presentation ST Elevation 
      Myocardial Infarction Patients in a Large Longitudinal Registry.
PG  - 480-486
LID - S1443-9506(23)00022-7 [pii]
LID - 10.1016/j.hlc.2022.12.012 [doi]
AB  - BACKGROUND: Recent studies suggest that the risk factor profile of patients 
      presenting with ST elevation myocardial infarction (STEMI) is changing. AIM: The 
      aim is to determine if there has been a shift of cardiovascular risk factors to 
      cardiometabolic causes in the first presentation STEMI population. METHOD: We 
      analysed data from a STEMI registry from a large tertiary referral percutaneous 
      coronary intervention centre to determine the prevalence and trends of the 
      modifiable risk factors of hypertension, diabetes, smoking and 
      hypercholesterolaemia. PARTICIPANTS: Consecutive first presentation STEMI 
      patients between January 2006 to December 2018. RESULTS: Among the 2,366 patients 
      included (mean age 59, SD 12.66, 80% male) the common risk factors were 
      hypertension (47%), hypercholesterolaemia (47%) current smoking (42%) and 
      diabetes (27%). Over the 13 years, patients with diabetes (20% to 26%, OR 1.09 
      per year, CI 1.06-1.11, p<0.001) and patients with no modifiable risk factors 
      increased (9% to 17%, OR 1.08, CI 1.04-1.11, p<0.001). Concurrently there was a 
      fall in prevalence of hypercholesterolaemia, (47% to 37%, OR 0.94 per year, CI 
      0.92-0.96, p<0.001) and smoking (44% to 41%, OR 0.94, CI 0.92-0.96, p<0.001) but 
      no significant change in rates of hypertension (53% to 49%, OR 0.99, CI 
      0.97-1.01, p=0.25). CONCLUSION: The risk factor profile of first presentation 
      STEMI has changed over time with a reduction in smoking and a concurrent rise in 
      patients with no traditional risk factors. This suggests the mechanism of STEMI 
      may be changing and further investigation of potential causal factors is 
      warranted for the prevention and management of cardiovascular disease.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Kazi, Samia N
AU  - Kazi SN
AD  - Department of Cardiology, Westmead Hospital, Sydney, NSW, Australia; Westmead 
      Applied Research Centre and Faculty of Medicine and Health, University of Sydney, 
      Sydney, NSW, Australia.
FAU - Von Huben, Amy
AU  - Von Huben A
AD  - Westmead Applied Research Centre and Faculty of Medicine and Health, University 
      of Sydney, Sydney, NSW, Australia.
FAU - Marschner, Simone
AU  - Marschner S
AD  - Westmead Applied Research Centre and Faculty of Medicine and Health, University 
      of Sydney, Sydney, NSW, Australia.
FAU - Chong, James J H
AU  - Chong JJH
AD  - Department of Cardiology, Westmead Hospital, Sydney, NSW, Australia; Centre for 
      Heart Research, The Westmead Institute for Medical Research, Sydney, NSW, 
      Australia.
FAU - Denniss, Alan Robert
AU  - Denniss AR
AD  - Department of Cardiology, Westmead Hospital, Sydney, NSW, Australia; Department 
      of Cardiology, Blacktown Hospital, Sydney, NSW, Australia; School of Medicine, 
      Western Sydney University, Sydney, NSW, Australia; Sydney Medical School, 
      University of Sydney, Sydney, NSW, Australia.
FAU - Ong, Andrew T L
AU  - Ong ATL
AD  - Department of Cardiology, Westmead Hospital, Sydney, NSW, Australia.
FAU - Chow, Clara K
AU  - Chow CK
AD  - Department of Cardiology, Westmead Hospital, Sydney, NSW, Australia; Westmead 
      Applied Research Centre and Faculty of Medicine and Health, University of Sydney, 
      Sydney, NSW, Australia. Electronic address: clara.chow@sydney.edu.au.
LA  - eng
PT  - Journal Article
DEP - 20230216
PL  - Australia
TA  - Heart Lung Circ
JT  - Heart, lung & circulation
JID - 100963739
SB  - IM
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Female
MH  - *ST Elevation Myocardial Infarction/diagnosis/epidemiology
MH  - *Hypercholesterolemia/complications/epidemiology
MH  - Risk Factors
MH  - *Diabetes Mellitus/epidemiology
MH  - *Hypertension/complications/epidemiology
MH  - *Percutaneous Coronary Intervention
MH  - Registries
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Cardiometabolic risk factors
OT  - Cardiovascular diseases
OT  - Heart disease risk factors
OT  - Myocardial infarction
OT  - ST elevation myocardial infarction
EDAT- 2023/02/22 06:00
MHDA- 2023/04/24 06:41
CRDT- 2023/02/21 16:13
PHST- 2021/10/13 00:00 [received]
PHST- 2022/08/18 00:00 [revised]
PHST- 2022/12/20 00:00 [accepted]
PHST- 2023/04/24 06:41 [medline]
PHST- 2023/02/22 06:00 [pubmed]
PHST- 2023/02/21 16:13 [entrez]
AID - S1443-9506(23)00022-7 [pii]
AID - 10.1016/j.hlc.2022.12.012 [doi]
PST - ppublish
SO  - Heart Lung Circ. 2023 Apr;32(4):480-486. doi: 10.1016/j.hlc.2022.12.012. Epub 
      2023 Feb 16.