PMID- 36801661 OWN - NLM STAT- MEDLINE DCOM- 20230314 LR - 20230616 IS - 1879-1360 (Electronic) IS - 0022-3999 (Linking) VI - 167 DP - 2023 Apr TI - The link between cardiac status and depression and anxiety in implantable cardioverter defibrillator patients: Design and first results of the PSYCHE-ICD study. PG - 111182 LID - S0022-3999(23)00037-5 [pii] LID - 10.1016/j.jpsychores.2023.111182 [doi] AB - OBJECTIVE: Depression and anxiety in patients with an implantable cardioverter-defibrillator (ICD) are associated with adverse outcomes. This study describes the design of the PSYCHE-ICD study and evaluates the correlation between cardiac status and depression and anxiety in ICD patients. METHODS: We included 178 patients. Prior to implantation, patients completed validated psychological questionnaires for depression, anxiety and personality traits. Cardiac status was evaluated by means of left ventricular ejection fraction assessment (LVEF), New York Heart Association (NYHA) functional class, 6-minute walk test (6MWT), and 24-h Holter monitoring for heart rate variability (HRV). A cross-sectional analysis was performed. Follow-up with annual study visits, including repeated full cardiac evaluation, will continue 36 months after ICD implantation. RESULTS: Depressive symptoms were present in 62 (35%) and anxiety in 56 (32%) patients. Values of depression and anxiety significantly increased with higher NYHA class (P < 0.001). Depression symptoms were correlated with a reduced 6MWT (411 +/- 128 vs. 488 +/- 89, P < 0.001), higher heart rate (74 +/- 13 vs. 70 +/- 13, P = 0.02), higher thyroid stimulation hormone levels (1.8 [1.3-2.8] vs 1.5 [1.0-2.2], P = 0.03) and multiple HRV parameters. Anxiety symptoms were correlated with higher NYHA class and a reduced 6MWT (433 +/- 112 vs 477 +/- 102, P = 0.02). CONCLUSION: A substantial part of patients receiving an ICD have symptoms of depression and anxiety at time of ICD implantation. Depression and anxiety were correlated with multiple cardiac parameters, suggesting a possible biological links between psychological distress and cardiac disease in ICD patients. CI - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved. FAU - van der Lingen, Anne-Lotte C J AU - van der Lingen ACJ AD - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Cardiology, Amsterdam Cardiovascular Sciences, De Boelelaan 1117, Amsterdam, the Netherlands. FAU - Rijnierse, Mischa T AU - Rijnierse MT AD - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Cardiology, Amsterdam Cardiovascular Sciences, De Boelelaan 1117, Amsterdam, the Netherlands. FAU - Hooghiemstra, Astrid M AU - Hooghiemstra AM AD - Amsterdam UMC, Vrije Universiteit Amsterdam, Alzheimer Center and Department of Neurology, Amsterdam Neurosciences, De Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Humanities, Amsterdam Public Health Research Institute, De Boelelaan 1089a, 1081 HV, Amsterdam, the Netherlands. FAU - Elshout, Saskia AU - Elshout S AD - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Cardiology, Amsterdam Cardiovascular Sciences, De Boelelaan 1117, Amsterdam, the Netherlands. FAU - van Halm, Vokko P AU - van Halm VP AD - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Cardiology, Amsterdam Cardiovascular Sciences, De Boelelaan 1117, Amsterdam, the Netherlands. FAU - Batelaan, Neeltje M AU - Batelaan NM AD - Amsterdam UMC, Vrije Universiteit, Department of Psychiatry, Amsterdam Public Health Research Institute, De Boelelaan 1117, Amsterdam, the Netherlands; GGZ inGeest, Specialized Mental Health Care, Amsterdam, the Netherlands. FAU - van Rossum, Albert C AU - van Rossum AC AD - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Cardiology, Amsterdam Cardiovascular Sciences, De Boelelaan 1117, Amsterdam, the Netherlands. FAU - Pedersen, Susanne S AU - Pedersen SS AD - University of Southern Denmark, Department of Psychology, Odense, Denmark; Odense University Hospital, Department of Cardiology, Odense, Denmark. FAU - Leeuwis, Anna E AU - Leeuwis AE AD - Amsterdam UMC, Vrije Universiteit Amsterdam, Alzheimer Center and Department of Neurology, Amsterdam Neurosciences, De Boelelaan 1117, Amsterdam, the Netherlands; GGZ inGeest, Specialized Mental Health Care, Amsterdam, the Netherlands. FAU - Allaart, Cornelis P AU - Allaart CP AD - Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Cardiology, Amsterdam Cardiovascular Sciences, De Boelelaan 1117, Amsterdam, the Netherlands. Electronic address: cp.allaart@amsterdamumc.nl. LA - eng PT - Journal Article DEP - 20230210 PL - England TA - J Psychosom Res JT - Journal of psychosomatic research JID - 0376333 SB - IM CIN - J Psychosom Res. 2023 Aug;171:111390. PMID: 37270908 MH - Humans MH - *Defibrillators, Implantable MH - Depression/psychology MH - Stroke Volume MH - Cross-Sectional Studies MH - Ventricular Function, Left MH - Anxiety/psychology OTO - NOTNLM OT - Anxiety OT - Autonomic function OT - Depression OT - Heart failure OT - Implantable cardioverter defibrillator COIS- Declaration of Competing Interest All authors have completed the Unified Competing Interest form at http://www.icmje.org/coi_disclosure.pdf and declare that AE Leeuwis and AM Hooghiemstra are part of the Heart-Brain Connection crossroads (HBCx) consortium of the Dutch CardioVascular Alliance (DCVA). HBCx has received funding from the Dutch Heart Foundation under grant agreement 2018-28. ACJ van der Lingen, MT Rijnierse, S. Elshout, VP van Halm, NM Batelaan, AC van Rossum, SS Pedersen and CP Allaart have nothing to disclose. EDAT- 2023/02/22 06:00 MHDA- 2023/03/15 06:00 CRDT- 2023/02/21 16:32 PHST- 2021/09/27 00:00 [received] PHST- 2023/01/07 00:00 [revised] PHST- 2023/02/03 00:00 [accepted] PHST- 2023/02/22 06:00 [pubmed] PHST- 2023/03/15 06:00 [medline] PHST- 2023/02/21 16:32 [entrez] AID - S0022-3999(23)00037-5 [pii] AID - 10.1016/j.jpsychores.2023.111182 [doi] PST - ppublish SO - J Psychosom Res. 2023 Apr;167:111182. doi: 10.1016/j.jpsychores.2023.111182. Epub 2023 Feb 10.