PMID- 36802923
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1940-2465 (Electronic)
IS  - 1066-8969 (Linking)
VI  - 31
IP  - 7
DP  - 2023 Oct
TI  - Biphenotypic Sinonasal Sarcoma: A Genetically Confirmed Case Showing Bone 
      Invasion Accompanying a Non-neoplastic Respiratory Epithelium.
PG  - 1414-1419
LID - 10.1177/10668969231152577 [doi]
AB  - Biphenotypic sinonasal sarcoma is a newly established tumor entity that is 
      associated with distinct clinicopathological findings. Biphenotypic sinonasal 
      sarcoma is a rare, low-grade spindle cell sarcoma that arises in middle-aged 
      females, exclusively in the sinonasal tract. A fusion gene involving PAX3 is 
      detected in most biphenotypic sinonasal sarcomas, which aids in its diagnosis. 
      Here, we report a case of biphenotypic sinonasal sarcoma with its cytological 
      findings. The patient was a 73-year-old woman who presented with purulent nasal 
      discharge and dull pain in the left cheek area. Computed tomography showed a mass 
      extending from the left nasal cavity to the left ethmoid sinus, the left frontal 
      sinus, and the frontal skull base. She underwent a combined transcranial and 
      endoscopic approach for en bloc resection with a safety margin. Histologically, 
      spindle-shaped tumor cells have been thought to proliferate mainly in the 
      subepithelial stroma. Here, nasal mucosal epithelial hyperplasia was noted, and 
      the tumor had invaded the bone tissue accompanying the epithelial cells. 
      Fluorescence in situ hybridization (FISH) analysis showed a PAX3 rearrangement, 
      and next-generation sequencing identified a PAX3::MAML3 fusion. Based on FISH, 
      split signals were observed not in respiratory cells but in stromal cells. This 
      indicated that respiratory cells were non-neoplastic. In the diagnosis of 
      biphenotypic sinonasal sarcoma, the inverted growth of the respiratory epithelium 
      can be a diagnostic pitfall. FISH analysis using a PAX3 break-apart probe is 
      helpful not only for an accurate diagnosis but also for detecting the true 
      neoplastic cells.
FAU - Muraoka, Erika
AU  - Muraoka E
AD  - Department of Diagnostic Pathology, Yokohama City University Hospital, Yokohama, 
      Japan. RINGGOLD: 218758
AD  - Department of Molecular Pathology, Yokohama City University, Graduate School of 
      Medicine, Yokohama, Japan. RINGGOLD: 26438
FAU - Kato, Ikuma
AU  - Kato I
AUID- ORCID: 0000-0002-7731-9509
AD  - Department of Molecular Pathology, Yokohama City University, Graduate School of 
      Medicine, Yokohama, Japan. RINGGOLD: 26438
FAU - Matsumura, Mai
AU  - Matsumura M
AD  - Department of Pathology, Yokohama City University, Graduate School of Medicine, 
      Yokohama, Japan. RINGGOLD: 26438
FAU - Arai, Yasuhiro
AU  - Arai Y
AD  - Department of Otolaryngology, Head and Neck Surgery, Yokohama City University 
      Hospital, Yokohama, Japan. RINGGOLD: 218758
FAU - Suenaga, Jun
AU  - Suenaga J
AD  - Department of Neurosurgery, Yokohama City University Hospital, Yokohama, Japan. 
      RINGGOLD: 218758
FAU - Yamanaka, Shoji
AU  - Yamanaka S
AD  - Department of Diagnostic Pathology, Yokohama City University Hospital, Yokohama, 
      Japan. RINGGOLD: 218758
FAU - Fujii, Satoshi
AU  - Fujii S
AD  - Department of Diagnostic Pathology, Yokohama City University Hospital, Yokohama, 
      Japan. RINGGOLD: 218758
AD  - Department of Molecular Pathology, Yokohama City University, Graduate School of 
      Medicine, Yokohama, Japan. RINGGOLD: 26438
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20230219
PL  - United States
TA  - Int J Surg Pathol
JT  - International journal of surgical pathology
JID - 9314927
SB  - IM
MH  - Middle Aged
MH  - Female
MH  - Humans
MH  - Aged
MH  - In Situ Hybridization, Fluorescence
MH  - *Paranasal Sinus Neoplasms/diagnosis/genetics/pathology
MH  - *Sarcoma/pathology
MH  - *Soft Tissue Neoplasms
MH  - Respiratory Mucosa/pathology
MH  - Bone and Bones/pathology
OTO - NOTNLM
OT  - PAX3::MAML3
OT  - biphenotypic sinonasal sarcoma
OT  - cytology
OT  - fluorescence in situ hybridization
COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2023/02/22 06:00
MHDA- 2023/10/23 12:45
CRDT- 2023/02/21 17:37
PHST- 2023/10/23 12:45 [medline]
PHST- 2023/02/22 06:00 [pubmed]
PHST- 2023/02/21 17:37 [entrez]
AID - 10.1177/10668969231152577 [doi]
PST - ppublish
SO  - Int J Surg Pathol. 2023 Oct;31(7):1414-1419. doi: 10.1177/10668969231152577. Epub 
      2023 Feb 19.