PMID- 36802993
OWN - NLM
STAT- MEDLINE
DCOM- 20230731
LR  - 20230731
IS  - 1551-3823 (Electronic)
IS  - 1551-3815 (Linking)
VI  - 42
IP  - 4
DP  - 2023 Aug
TI  - Expression of TFE3 in Cellular and Myxoid Type of Neurothekeoma: Four Cases in 
      Young Children and Adolescents.
PG  - 679-684
LID - 10.1080/15513815.2023.2181626 [doi]
AB  - Introduction: Cellular neurothekeoma is a benign tumor that mainly occurs in 
      young children and adolescents. The aberrant expression of transcription factor 
      E3 (TFE3) has not been reported in cellular neurothekeoma previously. Case 
      report: We report four cellular neurothekeoma with aberrant immunohistochemical 
      expression of TFE3 protein. The fluorescence in situ hybridization (FISH) showed 
      no TFE3 gene rearrangement or amplification. Discussion/Conclusion: TEF3 protein 
      expression may not be related to TFE3 gene translocation in cellular 
      neurothekeoma. TFE3 may be a potential pitfall in diagnosis, for several 
      malignant tumors in children also express TFE3. The aberrant expression of TFE3 
      may offer insights into cellular neurothekeoma etiology, and associated molecular 
      mechanisms.
FAU - Cheng, Yin
AU  - Cheng Y
AUID- ORCID: 0000-0003-1705-231X
AD  - Department of Pathology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing, China.
FAU - Zhang, Nan
AU  - Zhang N
AD  - Department of Pathology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing, China.
FAU - Deng, Zhijuan
AU  - Deng Z
AD  - Department of Pathology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing, China.
FAU - Guan, Xiaoxing
AU  - Guan X
AD  - Department of Pathology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing, China.
FAU - Xu, Jiaosheng
AU  - Xu J
AD  - Department of Dermatology, Beijing Children's Hospital, Capital Medical 
      University, National Center for Children's Health, Beijing, China.
FAU - Qu, Linlin
AU  - Qu L
AD  - Department of Pathology, Peking University People's Hospital, Beijing, China.
FAU - He, Lejian
AU  - He L
AUID- ORCID: 0000-0001-6141-9946
AD  - Department of Pathology, Beijing Children's Hospital, Capital Medical University, 
      National Center for Children's Health, Beijing, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20230221
PL  - England
TA  - Fetal Pediatr Pathol
JT  - Fetal and pediatric pathology
JID - 101230972
RN  - 0 (TFE3 protein, human)
SB  - IM
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - *Neurothekeoma/diagnosis/genetics
OTO - NOTNLM
OT  - Cellular neurothekeoma
OT  - Spitz nevus
OT  - TFE3
OT  - TFE3 gene translocation
EDAT- 2023/02/22 06:00
MHDA- 2023/07/24 06:43
CRDT- 2023/02/21 17:40
PHST- 2023/07/24 06:43 [medline]
PHST- 2023/02/22 06:00 [pubmed]
PHST- 2023/02/21 17:40 [entrez]
AID - 10.1080/15513815.2023.2181626 [doi]
PST - ppublish
SO  - Fetal Pediatr Pathol. 2023 Aug;42(4):679-684. doi: 10.1080/15513815.2023.2181626. 
      Epub 2023 Feb 21.