PMID- 36804493
OWN - NLM
STAT- MEDLINE
DCOM- 20230313
LR  - 20240502
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Print)
IS  - 0045-6535 (Linking)
VI  - 322
DP  - 2023 May
TI  - Brominated flame retardants and legacy organochlorines in archived human placenta 
      samples: Sex differences, temporal analysis and associations with infant birth 
      weight.
PG  - 138170
LID - S0045-6535(23)00437-X [pii]
LID - 10.1016/j.chemosphere.2023.138170 [doi]
AB  - Perinatal exposure to persistent organic pollutants (POPs) has been suggested to 
      play a role in the etiology of adverse pregnancy outcomes. This study evaluated 
      temporal changes in the accumulation of several classes of POPs, including 
      polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and 
      several organochlorine pesticides in human placenta and examined their 
      associations with birth outcomes at delivery. Placental tissues (n = 99) 
      previously collected and archived at the Duke University Medical Center from 2009 
      to 2015 were analyzed for 22 POPs using gas chromatography mass spectrometry. The 
      mean age of mothers was 30.6 years; 8% of newborns were characterized as low 
      birthweight (<2500 g). Of the 22 POPs targeted in the analysis, only p,p'-DDE, 
      BDE-47 and BDE-100 were detected in more than 50% of the samples, with median 
      concentrations of 0.110, 0.310, and 0.033 ng/g wet weight, respectively. 
      Placental PBDE concentrations generally decreased over time, particularly BDE-47. 
      Placental tissues associated with female infants had significantly higher levels 
      of BDE-100 than placental tissues associated with male infants (p = 0.02) and a 
      similar, but not statistically significant trend was observed for BDE-47 
      (p = 0.07). Multivariate regression models revealed that placental BDE-47 
      concentrations were associated with a significantly lower birthweight among male, 
      but not female infants. A similar, although non-statistically significant, trend 
      was observed for other POPs, further suggesting sex-specific associations between 
      gestational exposure to POPs and birthweight.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Ruis, Matthew
AU  - Ruis M
AD  - Nicholas School of the Environment, Levine Science Research Center, Duke 
      University, Durham, NC, 27710, USA.
FAU - Hoffman, Kate
AU  - Hoffman K
AD  - Nicholas School of the Environment, Levine Science Research Center, Duke 
      University, Durham, NC, 27710, USA; Children's Health Discovery Initiative, Duke 
      School of Medicine, North Carolina, United States.
FAU - Stapleton, Heather M
AU  - Stapleton HM
AD  - Nicholas School of the Environment, Levine Science Research Center, Duke 
      University, Durham, NC, 27710, USA. Electronic address: 
      heather.stapleton@duke.edu.
LA  - eng
GR  - R01 ES028110/ES/NIEHS NIH HHS/United States
GR  - R01 ES031419/ES/NIEHS NIH HHS/United States
GR  - T32 ES021432/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20230216
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
RN  - 0 (pentabrominated diphenyl ether 100)
RN  - 0 (Flame Retardants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Humans
MH  - Female
MH  - Male
MH  - Infant, Newborn
MH  - Infant
MH  - Pregnancy
MH  - Adult
MH  - Birth Weight
MH  - Placenta/chemistry
MH  - *Flame Retardants/analysis
MH  - Sex Characteristics
MH  - Maternal Exposure
MH  - Halogenated Diphenyl Ethers/analysis
MH  - *Hydrocarbons, Chlorinated/analysis
MH  - *Polychlorinated Biphenyls/analysis
MH  - *Environmental Pollutants/analysis
PMC - PMC10039416
MID - NIHMS1877843
OTO - NOTNLM
OT  - Birth outcomes
OT  - DDT
OT  - Flame retardants
OT  - PBDE
OT  - Placenta
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/02/23 06:00
MHDA- 2023/03/14 06:00
PMCR- 2024/05/01
CRDT- 2023/02/22 08:46
PHST- 2022/12/20 00:00 [received]
PHST- 2023/02/14 00:00 [revised]
PHST- 2023/02/15 00:00 [accepted]
PHST- 2023/02/23 06:00 [pubmed]
PHST- 2023/03/14 06:00 [medline]
PHST- 2023/02/22 08:46 [entrez]
PHST- 2024/05/01 00:00 [pmc-release]
AID - S0045-6535(23)00437-X [pii]
AID - 10.1016/j.chemosphere.2023.138170 [doi]
PST - ppublish
SO  - Chemosphere. 2023 May;322:138170. doi: 10.1016/j.chemosphere.2023.138170. Epub 
      2023 Feb 16.