PMID- 36805105 OWN - NLM STAT- MEDLINE DCOM- 20230811 LR - 20230811 IS - 2213-2201 (Electronic) VI - 11 IP - 8 DP - 2023 Aug TI - Most Patients With Autoimmune Chronic Spontaneous Urticaria Also Have Autoallergic Urticaria, but Not ViceVersa. PG - 2417-2425.e1 LID - S2213-2198(23)00184-8 [pii] LID - 10.1016/j.jaip.2023.02.006 [doi] AB - BACKGROUND: Two endotypes of chronic spontaneous urticaria (CSU) associated with mast cell-activating autoantibodies are described, namely autoallergic chronic spontaneous urticaria (aaCSU; with immunoglobulin E [IgE]-anti-autoallergens) and autoimmune chronic spontaneous urticaria (aiCSU; with IgG-anti-high-affinity receptor for the Fc region of immunoglobulin E [FcepsilonRI]/IgE). OBJECTIVE: To investigate the rates of CSU patients with aaCSU and aiCSU. METHODS: We analyzed 111 CSU patients for aaCSU (ie, IgE to thyroid peroxidase, interleukin 24) and for aiCSU (ie, a positive autologous serum skin and Basophil Activation Test plus immunoglobulin G [IgG]-anti-FcepsilonRI/IgE). Clinical and laboratory parameters were compared in patients with aaCSU, aiCSU, and both. RESULTS: Across 111 patients with CSU, 64 (58%) had aaCSU and 9 (8%) had aiCSU. Eight of the 9 aiCSU patients had aaCSU, but only 8 of 64 patients with aaCSU had aiCSU. In total, 7% (8 of 111) of patients had both aiCSU and aaCSU, 41% (46 of 111) had neither, and 16% (18 of 111) tested negative for all markers of aaCSU and aiCSU assessed. Patients with aaCSU or aiCSU are different from those without: patients with stand-alone aaCSU tend to be younger than non-aaCSU patients, aiCSU, and aaCSU/aiCSU overlapping subpopulations. In contrast, patients with aiCSU, with or without aaCSU coexistence, are more often female, have higher levels of thyroid peroxidase autoantibodies (both IgG and IgE), and show more severe quality of life impairment. CONCLUSIONS: Our novel finding that aiCSU coexisting with aaCSU needs to be confirmed in bigger cohorts and multicenter studies. Autoimmunity driven by autoreactive IgE and/or IgG in CSU needs further investigation for better understanding of the pathophysiology. CI - Copyright (c) 2023 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. FAU - Xiang, Yi-Kui AU - Xiang YK AD - Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany. FAU - Kolkhir, Pavel AU - Kolkhir P AD - Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany. FAU - Scheffel, Jorg AU - Scheffel J AD - Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany. FAU - Sauer, Merle AU - Sauer M AD - Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany. FAU - Vera, Carolina AU - Vera C AD - Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany. FAU - Frischbutter, Stefan AU - Frischbutter S AD - Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany. FAU - Krause, Karoline AU - Krause K AD - Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany. FAU - Siebenhaar, Frank AU - Siebenhaar F AD - Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany. FAU - Metz, Martin AU - Metz M AD - Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany. FAU - Maurer, Marcus AU - Maurer M AD - Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany. Electronic address: marcus.maurer@charite.de. FAU - Altrichter, Sabine AU - Altrichter S AD - Urticaria Center of Reference and Excellence (UCARE), Institute of Allergology, Charite-Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Allergology and Immunology, Berlin, Germany; Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology and Venereology, Comprehensive Allergy Center, Kepler Universitatsklinikum Linz, Austria. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230216 PL - United States TA - J Allergy Clin Immunol Pract JT - The journal of allergy and clinical immunology. In practice JID - 101597220 RN - EC 1.11.1.8 (Iodide Peroxidase) RN - 37341-29-0 (Immunoglobulin E) RN - 0 (Autoantibodies) RN - 0 (Receptors, IgE) RN - 0 (Immunoglobulin G) SB - IM MH - Humans MH - Female MH - Iodide Peroxidase MH - Quality of Life MH - Chronic Disease MH - *Chronic Urticaria MH - *Urticaria MH - Immunoglobulin E MH - Autoantibodies MH - Receptors, IgE MH - Immunoglobulin G OTO - NOTNLM OT - Autoallergy OT - Autoantibodies OT - Autoimmunity OT - Chronic spontaneous urticaria OT - IgE EDAT- 2023/02/23 06:00 MHDA- 2023/08/11 06:42 CRDT- 2023/02/22 09:18 PHST- 2022/11/24 00:00 [received] PHST- 2023/01/20 00:00 [revised] PHST- 2023/02/03 00:00 [accepted] PHST- 2023/08/11 06:42 [medline] PHST- 2023/02/23 06:00 [pubmed] PHST- 2023/02/22 09:18 [entrez] AID - S2213-2198(23)00184-8 [pii] AID - 10.1016/j.jaip.2023.02.006 [doi] PST - ppublish SO - J Allergy Clin Immunol Pract. 2023 Aug;11(8):2417-2425.e1. doi: 10.1016/j.jaip.2023.02.006. Epub 2023 Feb 16.