PMID- 36805367
OWN - NLM
STAT- MEDLINE
DCOM- 20230310
LR  - 20230922
IS  - 1533-4058 (Electronic)
IS  - 1533-4058 (Linking)
VI  - 31
IP  - 3
DP  - 2023 Mar 1
TI  - The Value of Immunohistochemical Expression of TOX, ICOS, and GATA-3 in the 
      Diagnosis of Mycosis Fungoides.
PG  - 163-171
LID - 10.1097/PAI.0000000000001110 [doi]
AB  - BACKGROUND: Mycosis fungoides (MF) is considered the commonest type of cutaneous 
      T-cell lymphoma representing about 50% of all primary cutaneous lymphomas. 
      Differentiation between MF and another inflammatory dermatitis (BIDs) is 
      important to ensure proper management. AIM: We aimed to evaluate the 
      immunohistochemical expression of T OX, ICOS, and GATA binding protein 3 (GATA-3) 
      in early stages MF (stage IA and IB) to establish their diagnostic value and to 
      guide the use of inhibitors in the treatment of cutaneous T-cell lymphomas. 
      MATERIALS AND METHODS: A retrospective study of 75 skin paraffin blocks (punch 
      biopsy) 40 cases of MF and 35 cases of eczematous dermatitis as a group 
      representing other inflammatory dermatitis were retrieved from archives of the 
      pathology department of our University, during the period from October 2017 to 
      May 2021. RESULTS: About 98% and 90% of patients in the MF group had positive T 
      OX and ICOS, while 70% of them had positive GATA-3. High expression of T OX, 
      ICOS, and GATA-3 was associated with higher stages. CONCLUSIONS: T OX is 
      considered a diagnostic marker for early MF. The importance of identifying novel 
      markers in MF expressed by immunohistochemistry, such as ICOS, has been 
      established. According to our results, GATA-3 could be used as an accessory 
      marker in the diagnosis of MF when combined with T OX and ICOS in a panel.
CI  - Copyright (c) 2023 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Atwa, Hanaa A
AU  - Atwa HA
AD  - Pathology Department, Faculty of Medicine, Zagazig University, Egypt.
FAU - Abdelrahman, Doaa I
AU  - Abdelrahman DI
LA  - eng
PT  - Journal Article
DEP - 20230220
PL  - United States
TA  - Appl Immunohistochem Mol Morphol
JT  - Applied immunohistochemistry & molecular morphology : AIMM
JID - 100888796
RN  - 0 (ICOS protein, human)
RN  - 0 (Inducible T-Cell Co-Stimulator Protein)
SB  - IM
MH  - Humans
MH  - Retrospective Studies
MH  - *Skin Neoplasms/pathology
MH  - *Mycosis Fungoides/diagnosis/metabolism/pathology
MH  - *Lymphoma, T-Cell, Cutaneous/diagnosis/pathology
MH  - *Dermatitis
MH  - Inducible T-Cell Co-Stimulator Protein
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/23 06:00
MHDA- 2023/03/11 06:00
CRDT- 2023/02/22 09:34
PHST- 2022/06/03 00:00 [received]
PHST- 2023/01/22 00:00 [accepted]
PHST- 2023/02/23 06:00 [pubmed]
PHST- 2023/03/11 06:00 [medline]
PHST- 2023/02/22 09:34 [entrez]
AID - 00129039-202303000-00004 [pii]
AID - 10.1097/PAI.0000000000001110 [doi]
PST - ppublish
SO  - Appl Immunohistochem Mol Morphol. 2023 Mar 1;31(3):163-171. doi: 
      10.1097/PAI.0000000000001110. Epub 2023 Feb 20.