PMID- 36808577
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231023
IS  - 1591-9528 (Electronic)
IS  - 1591-8890 (Linking)
VI  - 23
IP  - 6
DP  - 2023 Oct
TI  - T lymphocyte subsets and immunoglobulin and complement levels are associated with 
      the infection status of patients with antineutrophil cytoplasmic 
      antibody-associated vasculitis.
PG  - 2877-2884
LID - 10.1007/s10238-023-01021-4 [doi]
AB  - BACKGROUND: Infection is the leading cause of death in patients with 
      antineutrophil cytoplasmic antibody-associated vasculitis (AAV). The aim of this 
      study was to characterize the immunological features of infectious events 
      occurring in patients with newly diagnosed AAV and to identify possible risk 
      factors associated with infection. METHODS: The T lymphocyte subsets, 
      immunoglobulin, and complement levels of the groups were compared between 
      infected group and the noninfected group. Further, regression analysis was 
      conducted to determine the association of each variable with the risk of 
      infection. RESULTS: 280 patients with newly diagnosed AAV were enrolled. The 
      average levels of CD3(+) T cells (720.0 vs. 920.5, P < 0.001), CD3(+)CD4(+) T 
      cells (392.0 vs. 547.0, P < 0.001), and CD3(+)CD8(+) T cells (248.0 vs. 335.0, 
      P = 0.001), serum IgG (11.66 g/L vs. 13.59 g/L, P = 0.002), IgA (1.70 g/L vs. 
      2.44 g/L, P < 0.001), C3 (1.03 g/L vs. 1.09 g/L, P = 0.015), and C4 (0.24 g/L vs. 
      0.27 g/L, P < 0.001) were significantly lower in the infected group than in the 
      noninfected group. The levels of CD3(+)CD4(+) T cells (adjusted OR 0.997, 
      P = 0.018), IgG (adjusted OR 0.804, P = 0.004), and C4 (adjusted OR 0.001, 
      P = 0.013) were found independently associated with infection. CONCLUSIONS: 
      Patients of infected AAV and those without infection differ in T lymphocyte 
      subsets and immunoglobulin and complement levels. Furthermore, CD3(+)CD4(+) T 
      cells counts and serum IgG and C4 levels were independent risk factors with 
      infection in patients with newly diagnosed AAV.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
FAU - Liu, Rui
AU  - Liu R
AD  - Department of Rheumatology and Immunology, The First Affiliated Hospital of 
      Zhengzhou University, Zhengzhou, China.
FAU - Li, Mengdi
AU  - Li M
AD  - Department of Rheumatology and Immunology, The First Affiliated Hospital of 
      Zhengzhou University, Zhengzhou, China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Department of Rheumatology and Immunology, The First Affiliated Hospital of 
      Zhengzhou University, Zhengzhou, China.
FAU - Wang, Yan
AU  - Wang Y
AD  - Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, China.
FAU - Li, Wei
AU  - Li W
AUID- ORCID: 0000-0002-4073-4397
AD  - Department of Rheumatology and Immunology, The First Affiliated Hospital of 
      Zhengzhou University, Zhengzhou, China. libuwei2011@163.com.
FAU - Liu, Shengyun
AU  - Liu S
AUID- ORCID: 0000-0002-0426-1705
AD  - Department of Rheumatology and Immunology, The First Affiliated Hospital of 
      Zhengzhou University, Zhengzhou, China. fccliusy2@zzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230219
PL  - Italy
TA  - Clin Exp Med
JT  - Clinical and experimental medicine
JID - 100973405
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Humans
MH  - *Antibodies, Antineutrophil Cytoplasmic
MH  - CD8-Positive T-Lymphocytes
MH  - T-Lymphocyte Subsets
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
MH  - Immunoglobulin G
OTO - NOTNLM
OT  - ANCA-associated vasculitis
OT  - Complement
OT  - Immunoglobulin
OT  - Infection
OT  - T lymphocyte subset
EDAT- 2023/02/23 06:00
MHDA- 2023/10/23 12:41
CRDT- 2023/02/22 12:56
PHST- 2023/01/22 00:00 [received]
PHST- 2023/02/05 00:00 [accepted]
PHST- 2023/10/23 12:41 [medline]
PHST- 2023/02/23 06:00 [pubmed]
PHST- 2023/02/22 12:56 [entrez]
AID - 10.1007/s10238-023-01021-4 [pii]
AID - 10.1007/s10238-023-01021-4 [doi]
PST - ppublish
SO  - Clin Exp Med. 2023 Oct;23(6):2877-2884. doi: 10.1007/s10238-023-01021-4. Epub 
      2023 Feb 19.