PMID- 36808781
OWN - NLM
STAT- MEDLINE
DCOM- 20230705
LR  - 20230705
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 37
IP  - 7
DP  - 2023 Jul
TI  - The effect of a standardized capsule of Aloe vera gel on the quality of life in 
      patients with systolic heart failure: A randomized double-blind 
      placebo-controlled clinical trial.
PG  - 2800-2810
LID - 10.1002/ptr.7775 [doi]
AB  - This trial was designed to evaluate the effect of a standardized capsule of Aloe 
      vera gel (AVG) on the quality of life (QOL) in patients with systolic heart 
      failure (HF). Forty-two patients were randomly divided into two groups to receive 
      either AVG 150 mg or harmonized placebo capsules twice a day for 8 weeks. The 
      patients were evaluated before and after the intervention using the Minnesota 
      Living with Heart Failure Questionnaire (MLHFQ), New York Heart Association 
      (NYHA) functional class, six-minute walk test (6MWT), Insomnia Severity Index 
      (ISI), Pittsburgh Sleep Quality Index (PSQI) and STOP-BANG questionnaires. 
      Post-intervention, AVG group indicated a significant reduction in the total score 
      of MLHFQ (p < 0.001). The changes in MLHFQ and NYHA class were statistically 
      significant after taking medication (p < 0.001 and p = 0.004, respectively). The 
      change of 6MWT in the AVG group was more advanced; however, it was not 
      statistically significant (p = 0.353). Moreover, in the AVG group, the severity 
      of insomnia and obstructive sleep apnea decreased (p < 0.001, p = 0.01 
      respectively) and the sleep quality improved as well (p < 0.001). There were 
      significantly fewer adverse events reported in the AVG group (p = 0.047). 
      Therefore, AVG combined with standard medical therapy could provide more clinical 
      benefits for patients with systolic HF.
CI  - (c) 2023 John Wiley & Sons Ltd.
FAU - Sabbaghzadegan, Saeideh
AU  - Sabbaghzadegan S
AD  - Department of Traditional Medicine, School of Persian Medicine, Iran University 
      of Medical Sciences, Tehran, Iran.
AD  - Department of Traditional Medicine, Institute for Studies in Medical History, 
      Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, 
      Iran.
AD  - Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.
FAU - Soltani, Mohammad Hossein
AU  - Soltani MH
AD  - Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical 
      Sciences, Yazd, Iran.
FAU - Kamalinejad, Mohammad
AU  - Kamalinejad M
AD  - Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of 
      Medical Sciences, Tehran, Iran.
FAU - Bahrami, Mohsen
AU  - Bahrami M
AD  - Private Clinic, Tehran, Iran.
FAU - Kabir, Ali
AU  - Kabir A
AD  - Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Dadmehr, Majid
AU  - Dadmehr M
AUID- ORCID: 0000-0002-7032-8648
AD  - Department of Traditional Medicine, School of Persian Medicine, Iran University 
      of Medical Sciences, Tehran, Iran.
AD  - Department of Traditional Medicine, Institute for Studies in Medical History, 
      Persian and Complementary Medicine, Iran University of Medical Sciences, Tehran, 
      Iran.
LA  - eng
GR  - 98-2-63-15069/Iran University of Medical Sciences/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20230220
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Aloe vera gel)
RN  - 0 (Plant Preparations)
SB  - IM
MH  - Humans
MH  - Quality of Life
MH  - *Heart Failure, Systolic/drug therapy
MH  - *Sleep Initiation and Maintenance Disorders/drug therapy
MH  - Plant Preparations
MH  - Double-Blind Method
MH  - *Aloe
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Aloe vera gel
OT  - cardioprotective
OT  - heart failure
OT  - herbal medicine
OT  - quality of life
OT  - sleep apnea
EDAT- 2023/02/23 06:00
MHDA- 2023/07/05 06:42
CRDT- 2023/02/22 13:14
PHST- 2022/12/11 00:00 [revised]
PHST- 2021/12/31 00:00 [received]
PHST- 2022/12/18 00:00 [accepted]
PHST- 2023/07/05 06:42 [medline]
PHST- 2023/02/23 06:00 [pubmed]
PHST- 2023/02/22 13:14 [entrez]
AID - 10.1002/ptr.7775 [doi]
PST - ppublish
SO  - Phytother Res. 2023 Jul;37(7):2800-2810. doi: 10.1002/ptr.7775. Epub 2023 Feb 20.