PMID- 36809757
OWN - NLM
STAT- MEDLINE
DCOM- 20231115
LR  - 20240430
IS  - 2235-3186 (Electronic)
IS  - 1660-8151 (Linking)
VI  - 147 Suppl 1
DP  - 2023
TI  - Light Chain Deposition Disease Recurrence in Renal Allograft after Long-Term 
      Remission.
PG  - 96-100
LID - 10.1159/000529776 [doi]
AB  - Light chain deposition disease (LCDD) is a rare manifestation of monoclonal 
      gammopathy, which can lead to renal failure. We previously reported a detailed 
      recurrence process in a case of LCDD after renal transplantation. To the best of 
      our knowledge, no report has described the long-term clinical course and renal 
      pathology findings of recurrent LCDD in patients after renal transplantation. In 
      this case report, we describe the long-term clinical presentation and changes in 
      renal pathology of the same patient after early LCDD relapse in a renal 
      allograft. A 54-year-old woman with recurrent immunoglobulin A lambda-type LCDD in an 
      allograft was admitted 1 year post-transplant for bortezomib and dexamethasone 
      therapy. At 2 years post-transplantation, a graft biopsy performed after complete 
      remission was achieved, showing some glomeruli with residual nodular lesions 
      similar to the pre-treatment renal biopsy findings. However, the enlarged 
      subendothelial space disappeared. She remained in complete remission 
      serologically for 6 years. Subsequently, the ratio of serum kappa/lambda-free light chains 
      decreased gradually. She underwent a transplant biopsy approximately 12 years 
      after renal transplantation due to increased proteinuria and decreased renal 
      function. Compared with the previous graft biopsy, almost all glomeruli showed 
      advanced nodule formation and subendothelial expansion. Because the LCDD case 
      relapsed after long-term remission following renal transplantation, protocol 
      biopsy monitoring might be necessary.
CI  - (c) 2023 S. Karger AG, Basel.
FAU - Kobayashi, Azusa
AU  - Kobayashi A
AD  - Kidney Center, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 
      Nagoya, Japan.
FAU - Takeda, Asami
AU  - Takeda A
AD  - Kidney Center, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 
      Nagoya, Japan.
FAU - Shinjo, Hibiki
AU  - Shinjo H
AD  - Kidney Center, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 
      Nagoya, Japan.
FAU - Iguchi, Daiki
AU  - Iguchi D
AD  - Kidney Center, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 
      Nagoya, Japan.
FAU - Ito, Chiharu
AU  - Ito C
AD  - Kidney Center, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 
      Nagoya, Japan.
FAU - Okada, Eriko
AU  - Okada E
AD  - Kidney Center, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 
      Nagoya, Japan.
FAU - Goto, Norihiko
AU  - Goto N
AD  - Kidney Center, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 
      Nagoya, Japan.
FAU - Futamura, Kenta
AU  - Futamura K
AD  - Kidney Center, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 
      Nagoya, Japan.
FAU - Okada, Manabu
AU  - Okada M
AD  - Kidney Center, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 
      Nagoya, Japan.
FAU - Hiramitsu, Takahisa
AU  - Hiramitsu T
AD  - Kidney Center, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 
      Nagoya, Japan.
FAU - Narumi, Syunji
AU  - Narumi S
AD  - Kidney Center, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 
      Nagoya, Japan.
FAU - Watarai, Yoshihiko
AU  - Watarai Y
AD  - Kidney Center, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 
      Nagoya, Japan.
LA  - eng
PT  - Case Reports
DEP - 20230221
PL  - Switzerland
TA  - Nephron
JT  - Nephron
JID - 0331777
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Kidney Transplantation
MH  - *Multiple Myeloma/pathology/therapy
MH  - Kidney/physiology/pathology
MH  - *Paraproteinemias/pathology
MH  - Immunoglobulin Light Chains
MH  - Allografts/pathology
OTO - NOTNLM
OT  - Allograft kidney
OT  - Light chain deposition disease
OT  - Recurrent renal disease
EDAT- 2023/02/23 06:00
MHDA- 2023/11/15 06:42
CRDT- 2023/02/22 14:08
PHST- 2022/12/15 00:00 [received]
PHST- 2023/02/06 00:00 [accepted]
PHST- 2023/11/15 06:42 [medline]
PHST- 2023/02/23 06:00 [pubmed]
PHST- 2023/02/22 14:08 [entrez]
AID - 000529776 [pii]
AID - 10.1159/000529776 [doi]
PST - ppublish
SO  - Nephron. 2023;147 Suppl 1:96-100. doi: 10.1159/000529776. Epub 2023 Feb 21.