PMID- 36810539
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230224
IS  - 2079-9721 (Print)
IS  - 2079-9721 (Electronic)
IS  - 2079-9721 (Linking)
VI  - 11
IP  - 1
DP  - 2023 Feb 1
TI  - A Case of Light Chain Deposition Disease Leading to Acute Liver Failure and 
      Review of Literature.
LID - 10.3390/diseases11010024 [doi]
LID - 24
AB  - Light chain deposition disease (LCDD) is a monoclonal immunoglobulin deposition 
      disease characterized by light chain deposition in soft tissues and viscera, 
      causing systemic organ dysfunction with an underlying lymphoproliferative 
      disorder. While the kidney is the most affected organ, cardiac and hepatic 
      involvement is also seen with LCDD. Hepatic manifestation can range from mild 
      hepatic injury to fulminant liver failure. Herein, we are presenting a case of an 
      83-year-old woman with a monoclonal gammopathy of undetermined significance 
      (MGUS), who presented to our institution with acute liver failure progressing to 
      circulatory shock and multiorgan failure. After an extensive workup, a diagnosis 
      of hepatic LCDD was determined. In conjunction with the hematology and oncology 
      department, chemotherapy options were discussed, but given her poor prognosis, 
      the family decided to pursue a palliative route. Though establishing a prompt 
      diagnosis is important for any acute condition, the rarity of this condition, 
      along with paucity of data, makes timely diagnosis and treatment challenging. The 
      available literature shows variable rates of success with chemotherapy for 
      systemic LCDD. Despite chemotherapeutic advances, liver failure in LCDD indicates 
      a dismal prognosis, where further clinical trials are difficult owing to the low 
      prevalence of the condition. In our article, we will also be reviewing previous 
      case reports on this disease.
FAU - Gandhi, Mustafa
AU  - Gandhi M
AD  - Department of Internal Medicine, University of Missouri, Columbia, MO 65211, USA.
FAU - Pasha, Syed Bilal
AU  - Pasha SB
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      University of Missouri, Columbia, MO 65211, USA.
FAU - Reznicek, Emily
AU  - Reznicek E
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      University of Missouri, Columbia, MO 65211, USA.
FAU - Pasha, Syed Raheel
AU  - Pasha SR
AUID- ORCID: 0000-0003-0610-5674
AD  - Department of Medicine, Jinnah Sindh Medical University, Karachi 75510, Pakistan.
FAU - Ertugrul, Hamza
AU  - Ertugrul H
AUID- ORCID: 0000-0003-2022-8232
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      University of Missouri, Columbia, MO 65211, USA.
FAU - Araslanova, Adel
AU  - Araslanova A
AD  - Department of Medicine, University of South Florida, Tampa, FL 33620, USA.
FAU - Yin, Feng
AU  - Yin F
AD  - Department of Pathology, University of Missouri, Columbia, MO 65211, USA.
AD  - Department of Pathology, The University of Texas MD Anderson Cancer Center, 
      Houston, TX 77030, USA.
FAU - Tahan, Veysel
AU  - Tahan V
AUID- ORCID: 0000-0001-6796-9359
AD  - Division of Gastroenterology and Hepatology, Department of Internal Medicine, 
      University of Missouri, Columbia, MO 65211, USA.
LA  - eng
PT  - Case Reports
DEP - 20230201
PL  - Switzerland
TA  - Diseases
JT  - Diseases (Basel, Switzerland)
JID - 101636232
PMC - PMC9944111
OTO - NOTNLM
OT  - acute kidney injury
OT  - acute liver failure
OT  - gammopathy
OT  - immune
OT  - light change deposition disease
OT  - monoclonal
OT  - plasma cells
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/23 06:00
MHDA- 2023/02/23 06:01
PMCR- 2023/02/01
CRDT- 2023/02/22 14:39
PHST- 2022/12/20 00:00 [received]
PHST- 2023/01/26 00:00 [revised]
PHST- 2023/01/30 00:00 [accepted]
PHST- 2023/02/22 14:39 [entrez]
PHST- 2023/02/23 06:00 [pubmed]
PHST- 2023/02/23 06:01 [medline]
PHST- 2023/02/01 00:00 [pmc-release]
AID - diseases11010024 [pii]
AID - diseases-11-00024 [pii]
AID - 10.3390/diseases11010024 [doi]
PST - epublish
SO  - Diseases. 2023 Feb 1;11(1):24. doi: 10.3390/diseases11010024.