PMID- 36811711
OWN - NLM
STAT- MEDLINE
DCOM- 20240306
LR  - 20240306
IS  - 1433-8491 (Electronic)
IS  - 0940-1334 (Linking)
VI  - 274
IP  - 2
DP  - 2024 Mar
TI  - Top-down and bottom-up alterations of connectivity patterns of the 
      suprachiasmatic nucleus in chronic insomnia disorder.
PG  - 245-254
LID - 10.1007/s00406-022-01534-1 [doi]
AB  - The importance of the suprachiasmatic nucleus (SCN, also called the master 
      circadian clock) in regulating sleep and wakefulness has been confirmed by 
      multiple animal research. However, human studies of SCN in vivo are still 
      nascent. Recently, the development of resting-state functional magnetic resonance 
      imaging (fMRI) has made it possible to study SCN-related connectivity changes in 
      patients with chronic insomnia disorder (CID). Hence, this study aimed to explore 
      whether sleep-wake circuitry (i.e., communication between the SCN and other brain 
      regions) is disrupted in human insomnia. Forty-two patients with CID and 37 
      healthy controls (HCs) underwent fMRI scanning. Resting-state functional 
      connectivity (rsFC) and Granger causality analysis (GCA) were performed to find 
      abnormal functional and causal connectivity of the SCN in CID patients. In 
      addition, correlation analyses were conducted to detect associations between 
      features of disrupted connectivity and clinical symptoms. Compared to HCs, CID 
      patients showed enhanced rsFC of the SCN-left dorsolateral prefrontal cortex 
      (DLPFC), as well as reduced rsFC of the SCN-bilateral medial prefrontal cortex 
      (MPFC); these altered cortical regions belong to the "top-down" circuit. 
      Moreover, CID patients exhibited disrupted functional and causal connectivity 
      between the SCN and the locus coeruleus (LC) and the raphe nucleus (RN); these 
      altered subcortical regions constitute the "bottom-up" pathway. Importantly, the 
      decreased causal connectivity from the LC-to-SCN was associated with the duration 
      of disease in CID patients. These findings suggest that the disruption of the 
      SCN-centered "top-down" cognitive process and "bottom-up" wake-promoting pathway 
      may be intimately tied to the neuropathology of CID.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
FAU - Yu, Siyi
AU  - Yu S
AD  - Department of Acupuncture and Tuina, Chengdu University of Traditional Chinese 
      Medicine, Chengdu, China. cdutcmysy@gmail.com.
FAU - Shen, Zhifu
AU  - Shen Z
AD  - Department of Traditional Chinese Medicine, the Affiliated Hospital of North 
      Sichuan Medical College, Nanchong, China.
AD  - Department of Traditional Chinese and Western Medicine, North Sichuan Medical 
      College, Nanchong, China.
FAU - Xu, Hao
AU  - Xu H
AD  - Department of Acupuncture and Tuina, Chengdu University of Traditional Chinese 
      Medicine, Chengdu, China.
FAU - Xia, Zihao
AU  - Xia Z
AD  - Department of Acupuncture and Tuina, Chengdu University of Traditional Chinese 
      Medicine, Chengdu, China.
FAU - Peng, Wei
AU  - Peng W
AD  - Department of Acupuncture and Tuina, Chengdu University of Traditional Chinese 
      Medicine, Chengdu, China.
FAU - Hu, Youping
AU  - Hu Y
AD  - Department of Acupuncture and Tuina, Chengdu University of Traditional Chinese 
      Medicine, Chengdu, China.
FAU - Feng, Fen
AU  - Feng F
AD  - Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, 
      Chengdu, China.
FAU - Zeng, Fang
AU  - Zeng F
AD  - Department of Acupuncture and Tuina, Chengdu University of Traditional Chinese 
      Medicine, Chengdu, China. zengfang@cdutcm.edu.cn.
LA  - eng
GR  - 82004488/National Natural Science Foundation of China/
GR  - 2021YJ0176/Sichuan Province Science and Technology Support Program/
GR  - 2018YJ0249/Sichuan Province Science and Technology Support Program/
PT  - Journal Article
DEP - 20230222
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Sleep Initiation and Maintenance Disorders/diagnostic imaging
MH  - Suprachiasmatic Nucleus
MH  - Brain
MH  - Prefrontal Cortex/pathology
MH  - Magnetic Resonance Imaging/methods
OTO - NOTNLM
OT  - Causal connectivity
OT  - Chronic insomnia disorder
OT  - Functional connectivity
OT  - Granger causality analysis
OT  - Suprachiasmatic nucleus
EDAT- 2023/02/23 06:00
MHDA- 2024/03/06 06:44
CRDT- 2023/02/22 15:55
PHST- 2022/07/20 00:00 [received]
PHST- 2022/12/16 00:00 [accepted]
PHST- 2024/03/06 06:44 [medline]
PHST- 2023/02/23 06:00 [pubmed]
PHST- 2023/02/22 15:55 [entrez]
AID - 10.1007/s00406-022-01534-1 [pii]
AID - 10.1007/s00406-022-01534-1 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2024 Mar;274(2):245-254. doi: 
      10.1007/s00406-022-01534-1. Epub 2023 Feb 22.