PMID- 36812381
OWN - NLM
STAT- MEDLINE
DCOM- 20230405
LR  - 20230406
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 159
IP  - 4
DP  - 2023 Apr 4
TI  - Recurrent PRDM10 Fusions in Superficial CD34-Positive Fibroblastic Tumors : A 
      Clinicopathologic and Molecular Study of 10 Additional Cases of an Emerging Novel 
      Entity.
PG  - 367-378
LID - 10.1093/ajcp/aqac171 [doi]
AB  - OBJECTIVES: Superficial CD34-positive fibroblastic tumor (SCD34FT) is a rare 
      mesenchymal neoplasm. The genetic alterations of SCD34FT have yet to be 
      determined. Recent studies suggest it overlaps with PRDM10-rearranged soft tissue 
      tumor (PRDM10-STT). METHODS: This study aimed to characterize a series of 10 
      cases of SCD34FT using fluorescence in situ hybridization (FISH) and targeted 
      next-generation sequencing (NGS). RESULTS: The study recruited 7 men and 3 women 
      aged between 26 and 64 years. The tumors were located in the superficial soft 
      tissues of the thigh (8 cases), foot, and back (1 case each), ranging in size 
      from 1.5 to 7 cm. The tumors were composed of sheets and fascicles of plump 
      spindled to polygonal cells, with glassy cytoplasm and pleomorphic nuclei. 
      Mitotic activity was absent or low. Common and uncommon stromal findings included 
      foamy histiocytic infiltrates, myxoid changes, peripheral lymphoid aggregates, 
      large ectatic vessels, arborizing capillary vasculature, and hemosiderin 
      deposition. All tumors expressed CD34, and 4 demonstrated focal cytokeratin 
      immunoexpression. In 7 of 9 (77.8%) cases analyzed, FISH identified PRDM10 
      rearrangement. Targeted NGS revealed a MED12::PRDM10 fusion in 4 of 7 cases 
      tested. Follow-up showed no recurrence or metastasis. CONCLUSIONS: We demonstrate 
      recurrent PRDM10 rearrangements in SCD34FT and provide additional evidence of a 
      close relationship to PRDM10-STT.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of American 
      Society for Clinical Pathology. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Zhao, Ming
AU  - Zhao M
AUID- ORCID: 0000-0001-5971-7303
AD  - Department of Pathology, Cancer Center, Zhejiang Provincial People's Hospital, 
      People's Hospital of Hangzhou Medical College, Hangzhou, China.
FAU - Yin, Xiaona
AU  - Yin X
AD  - Department of Pathology, Hangzhou Women's Hospital, Hangzhou, China.
FAU - He, Huiying
AU  - He H
AD  - Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking 
      University Health Science Center, Beijing, China.
FAU - Fan, Yuqian
AU  - Fan Y
AD  - Department of Pathology, Cancer Center, Zhejiang Provincial People's Hospital, 
      People's Hospital of Hangzhou Medical College, Hangzhou, China.
FAU - Ru, Guoqing
AU  - Ru G
AD  - Department of Pathology, Cancer Center, Zhejiang Provincial People's Hospital, 
      People's Hospital of Hangzhou Medical College, Hangzhou, China.
FAU - Meng, Xuli
AU  - Meng X
AD  - Department of Breast Surgery, Cancer Center, Zhejiang Provincial People's 
      Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.
LA  - eng
GR  - LY21H160052/Zhejiang Provincial Natural Science Foundation/
GR  - 2023KY040/Zhejiang Provincial Medicine and Health Research Foundation/
GR  - LY21H160052/Natural Science Foundation of Zhejiang Province/
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (Transcription Factors)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (PRDM10 protein, human)
RN  - 0 (DNA-Binding Proteins)
SB  - IM
MH  - Humans
MH  - Female
MH  - In Situ Hybridization, Fluorescence
MH  - Transcription Factors/genetics
MH  - *Soft Tissue Neoplasms/genetics/pathology
MH  - *Neoplasms, Connective and Soft Tissue
MH  - Cell Nucleus/pathology
MH  - Biomarkers, Tumor/genetics
MH  - DNA-Binding Proteins/genetics
OTO - NOTNLM
OT  - PRDM10
OT  - Fluorescence in situ hybridization
OT  - Gene fusion
OT  - Next-generation sequencing
OT  - Superficial CD34-positive fibroblastic tumor
EDAT- 2023/02/23 06:00
MHDA- 2023/04/05 06:42
CRDT- 2023/02/22 16:27
PHST- 2022/10/13 00:00 [received]
PHST- 2022/12/06 00:00 [accepted]
PHST- 2023/04/05 06:42 [medline]
PHST- 2023/02/23 06:00 [pubmed]
PHST- 2023/02/22 16:27 [entrez]
AID - 7051170 [pii]
AID - 10.1093/ajcp/aqac171 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2023 Apr 4;159(4):367-378. doi: 10.1093/ajcp/aqac171.