PMID- 36813972 OWN - NLM STAT- MEDLINE DCOM- 20230421 LR - 20230519 IS - 1720-8319 (Electronic) IS - 1594-0667 (Print) IS - 1594-0667 (Linking) VI - 35 IP - 4 DP - 2023 Apr TI - Development and validation of an intrinsic capacity composite score in the Longitudinal Aging Study Amsterdam: a formative approach. PG - 815-825 LID - 10.1007/s40520-023-02366-2 [doi] AB - BACKGROUND: Intrinsic capacity (IC) defined by the WHO refers to the composite of five domains of capacities. So far, developing and validating a standardized overall score of the concept have been challenging partly because its conceptual framework has been unclear. We consider that a person's IC is determined by its domain-specific indicators suggesting a formative measurement model. AIMS: To develop an IC score applying a formative approach and assess its validity. METHODS: The study sample (n = 1908) consisted of 57-88-year-old participants from the Longitudinal Aging Study Amsterdam (LASA). We used logistic regression models to select the indicators to the IC score with 6-year functional decline as an outcome. An IC score (range 0-100) was constructed for each participant. We examined the known-groups' validity of the IC score by comparing groups based on age and number of chronic diseases. The criterion validity of the IC score was assessed with 6-year functional decline and 10-year mortality as outcomes. RESULTS: The constructed IC score included seven indicators covering all five domains of the construct. The mean IC score was 66.7 (SD 10.3). The scores were higher among younger participants and those who had lower number of chronic diseases. After adjustment for sociodemographic indicators, chronic diseases, and BMI, a one-point higher IC score was associated with a 7% decreased risk for 6-year functional decline and a 2% decreased risk for 10-year mortality. CONCLUSIONS: The developed IC score demonstrated discriminative ability according to age and health status and is associated with subsequent functional decline and mortality. CI - (c) 2023. The Author(s). FAU - Koivunen, Kaisa AU - Koivunen K AUID- ORCID: 0000-0002-0710-0069 AD - Epidemiology and Data Science, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. kaisa.m.koivunen@jyu.fi. AD - Faculty of Sport and Health Sciences and Gerontology Research Center, University of Jyvaskyla, Rautpohjankatu 8, P.O. Box 35, 40014, Jyvaskyla, Finland. kaisa.m.koivunen@jyu.fi. FAU - Hoogendijk, Emiel O AU - Hoogendijk EO AD - Epidemiology and Data Science, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. AD - Department of General Practice, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. AD - Aging and Later Life, Amsterdam Public Health Research Institute, De Boelelaan 1117, Amsterdam, The Netherlands. FAU - Schaap, Laura A AU - Schaap LA AD - Aging and Later Life, Amsterdam Public Health Research Institute, De Boelelaan 1117, Amsterdam, The Netherlands. AD - Department of Health Sciences, Faculty of Science, Amsterdam Public Health Research Institute, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1081, 1081 HV, Amsterdam, The Netherlands. FAU - Huisman, Martijn AU - Huisman M AD - Epidemiology and Data Science, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. AD - Aging and Later Life, Amsterdam Public Health Research Institute, De Boelelaan 1117, Amsterdam, The Netherlands. AD - Department of Sociology, Vrije Universiteit Amsterdam, De Boelelaan 1105, 1081 HV, Amsterdam, The Netherlands. FAU - Heymans, Martijn W AU - Heymans MW AD - Epidemiology and Data Science, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. AD - Aging and Later Life, Amsterdam Public Health Research Institute, De Boelelaan 1117, Amsterdam, The Netherlands. FAU - van Schoor, Natasja M AU - van Schoor NM AD - Epidemiology and Data Science, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. AD - Aging and Later Life, Amsterdam Public Health Research Institute, De Boelelaan 1117, Amsterdam, The Netherlands. LA - eng GR - 693045/European Research Council/International GR - 310526/Academy of Finland/ PT - Journal Article DEP - 20230223 PL - Germany TA - Aging Clin Exp Res JT - Aging clinical and experimental research JID - 101132995 SB - IM MH - Humans MH - Aged MH - Aged, 80 and over MH - *Aging MH - Longitudinal Studies MH - Chronic Disease MH - Logistic Models PMC - PMC10115715 OTO - NOTNLM OT - Functional ability OT - Healthy aging OT - Measurement OT - WHO COIS- The authors declare that they have no conflict of interest. EDAT- 2023/02/23 06:00 MHDA- 2023/04/21 06:41 PMCR- 2023/02/23 CRDT- 2023/02/22 23:24 PHST- 2022/10/13 00:00 [received] PHST- 2023/02/05 00:00 [accepted] PHST- 2023/04/21 06:41 [medline] PHST- 2023/02/23 06:00 [pubmed] PHST- 2023/02/22 23:24 [entrez] PHST- 2023/02/23 00:00 [pmc-release] AID - 10.1007/s40520-023-02366-2 [pii] AID - 2366 [pii] AID - 10.1007/s40520-023-02366-2 [doi] PST - ppublish SO - Aging Clin Exp Res. 2023 Apr;35(4):815-825. doi: 10.1007/s40520-023-02366-2. Epub 2023 Feb 23.