PMID- 36814552 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230224 IS - 2312-0541 (Print) IS - 2312-0541 (Electronic) IS - 2312-0541 (Linking) VI - 9 IP - 1 DP - 2023 Jan TI - Epidemiological characteristics of nontuberculous mycobacteriosis and bronchiectasis: comparative study using national mortality statistics from 1970 to 2015 in Japan. LID - 00424-2022 [pii] LID - 10.1183/23120541.00424-2022 [doi] AB - BACKGROUND: This study assessed longitudinal national data on mortality due to nontuberculous mycobacteriosis (NTMosis) and bronchiectasis and the association between the two diseases. METHODS: We analysed the national death statistics of Japan from 1970 to 2015. The International Classification of Disease (ICD) codes were used to extract the relevant data. Crude mortality, age-adjusted mortality and standardised mortality rates were calculated using vital statistics and the population in 2000. We also identified domestic publications related to NTMosis and bronchiectasis with an internet-based search system. RESULTS: The total number of bronchiectasis-related deaths remained at the same level, which was approximately 1000, for 45 years, although the number of deaths has consistently decreased in males but increased in females since the mid-1990s. A substantial increasing trend in females was also observed for NTMosis in the same period. The age-adjusted mortality data showed an increase in mortality in women due to NTMosis and confirmed the trend in bronchiectasis in women. The patterns in the number of domestic reports showed a recent slight increase in bronchiectasis and a marked increase in NTMosis. CONCLUSIONS: The trends in bronchiectasis-related mortality differed by sex. The epidemiological trends in the two diseases were associated, especially in elderly females since the mid-1990s. It is suggested that pulmonary NTMosis without pre-existing bronchiectasis might be a leading cause of postinfectious bronchiectasis in Japan. CI - Copyright (c)The authors 2023. FAU - Morimoto, Kozo AU - Morimoto K AD - Division of Clinical Research, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. AD - The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan. AD - Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. FAU - Iwai, Kazuro AU - Iwai K AD - The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan. FAU - Yoshiyama, Takashi AU - Yoshiyama T AD - The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan. AD - Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. FAU - Ito, Masashi AU - Ito M AD - Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. FAU - Uesugi, Fumiko AU - Uesugi F AD - Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. FAU - Asakura, Takanori AU - Asakura T AUID- ORCID: 0000-0003-3122-6937 AD - Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. AD - Department of Clinical Medicine (Laboratory of Bioregulatory Medicine), Kitasato University School of Pharmacy, Tokyo, Japan. FAU - Osawa, Takeshi AU - Osawa T AUID- ORCID: 0000-0002-6657-7916 AD - Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. FAU - Furuuchi, Koji AU - Furuuchi K AD - Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. FAU - Kurashima, Atsuyuki AU - Kurashima A AD - Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. FAU - Fujiwara, Keiji AU - Fujiwara K AUID- ORCID: 0000-0002-1139-1604 AD - Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. FAU - Hasegawa, Naoki AU - Hasegawa N AD - Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan. FAU - Tanaka, Yoshiaki AU - Tanaka Y AD - Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. FAU - Shoji, Kudoh AU - Shoji K AD - Japan Anti-Tuberculosis Association, Tokyo, Japan. FAU - Shiraishi, Yuji AU - Shiraishi Y AD - Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. FAU - Mitarai, Satoshi AU - Mitarai S AUID- ORCID: 0000-0002-2288-077X AD - The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan. FAU - Ato, Manabu AU - Ato M AUID- ORCID: 0000-0002-3178-2645 AD - Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama, Japan. FAU - Ohta, Ken AU - Ohta K AD - Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan. LA - eng PT - Journal Article DEP - 20230220 PL - England TA - ERJ Open Res JT - ERJ open research JID - 101671641 PMC - PMC9940714 COIS- Conflict of interest: K. Morimoto reports grants from AMED during the study, JSPS KAKENHI and lecture fees from INSMED outside the submitted work. T. Asakura reports grants from JSPS KAKENHI and AMED outside the submitted work. Y. Tanaka reports personal fees from Nippon Boehringer Ingelheim Co, Ltd, outside the submitted work. M. Ato reports grants from AMED outside the submitted work. N. Hasegawa reports grants from AMED and JSPS KAKENHI, and lecture fees from INSMED outside the submitted work. K. Iwai, T. Yoshiyama, M. Ito, F. Uesugi, T. Osawa, K. Furuuchi, A. Kurahsima, K. Fujiwara, K. Shoji, Y. Shiraishi, S. Mitarai, and K. Ohta declare that they have no competing interests. EDAT- 2023/02/24 06:00 MHDA- 2023/02/24 06:01 PMCR- 2023/02/20 CRDT- 2023/02/23 02:06 PHST- 2022/08/22 00:00 [received] PHST- 2022/11/02 00:00 [accepted] PHST- 2023/02/23 02:06 [entrez] PHST- 2023/02/24 06:00 [pubmed] PHST- 2023/02/24 06:01 [medline] PHST- 2023/02/20 00:00 [pmc-release] AID - 00424-2022 [pii] AID - 10.1183/23120541.00424-2022 [doi] PST - epublish SO - ERJ Open Res. 2023 Feb 20;9(1):00424-2022. doi: 10.1183/23120541.00424-2022. eCollection 2023 Jan.