PMID- 36816573
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230403
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 14
DP  - 2023
TI  - Elucidation of the mechanism underlying impaired sensorimotor gating in patients 
      with primary blepharospasm using prepulse inhibition.
PG  - 1105483
LID - 10.3389/fneur.2023.1105483 [doi]
LID - 1105483
AB  - OBJECTIVE: We aimed to analyze prepulse inhibition (PPI) impairment of the blink 
      reflex in patients with primary blepharospasm (BSP). METHODS: We recruited 30 BSP 
      patients and 20 gender- and age-matched healthy controls (HCs). Weak electrical 
      stimulation was applied to the right index finger at interstimulus intervals 
      (ISIs) of 120, 200, and 300 ms before the supraorbital nerve stimulation to 
      investigate PPI size [PPI size = (1 - R(2) area at prepulse trials/R(2) area at 
      baseline trials) x 100%]. RESULTS: The prepulse stimulus significantly inhibited 
      the R (2) component at the three ISIs in both groups, but less inhibition was 
      shown in the BSP group (p < 0.05). In HCs, the prepulse stimulus induced 
      prolonged R (2) and R (2c) latencies at the three ISIs and increased the R (1) 
      amplitude at ISIs of 120 ms; these changes were absent in BSP patients. In the 
      BSP group, patients with sensory tricks showed better PPI than patients without 
      sensory tricks. Disease duration and motor symptom severity showed no significant 
      correlation with PPI size. CONCLUSION: In BSP patients, PPI was impaired while R 
      (1) facilitation was absent. PPI size did not correlate with the motor symptom 
      severity and disease duration. Patients with sensory tricks showed better PPI 
      than those without sensory tricks.
CI  - Copyright (c) 2023 Hao, Huang, Yin, Wang, Lu, Liang and Song.
FAU - Hao, Xinqing
AU  - Hao X
AD  - Department of Neurology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Huang, Xiaofeng
AU  - Huang X
AD  - Department of Neurology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Yin, Xiaoxue
AU  - Yin X
AD  - Department of Neurology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Wang, Hai-Yang
AU  - Wang HY
AD  - Department of Neurology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
AD  - Department of Neurology, Jining No. 1 People's Hospital, Jining, China.
FAU - Lu, Ren
AU  - Lu R
AD  - Department of Neurology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Liang, Zhanhua
AU  - Liang Z
AD  - Department of Neurology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
FAU - Song, Chunli
AU  - Song C
AD  - Department of Neurology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, China.
LA  - eng
PT  - Journal Article
DEP - 20230201
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
EIN - Front Neurol. 2023 Mar 16;14:1174368. PMID: 37006482
PMC - PMC9929365
OTO - NOTNLM
OT  - blink reflex
OT  - prepulse inhibition
OT  - primary blepharospasm
OT  - sensorimotor integration
OT  - sensory trick
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/02/24 06:00
MHDA- 2023/02/24 06:01
PMCR- 2023/02/01
CRDT- 2023/02/23 09:23
PHST- 2022/11/22 00:00 [received]
PHST- 2023/01/16 00:00 [accepted]
PHST- 2023/02/23 09:23 [entrez]
PHST- 2023/02/24 06:00 [pubmed]
PHST- 2023/02/24 06:01 [medline]
PHST- 2023/02/01 00:00 [pmc-release]
AID - 10.3389/fneur.2023.1105483 [doi]
PST - epublish
SO  - Front Neurol. 2023 Feb 1;14:1105483. doi: 10.3389/fneur.2023.1105483. eCollection 
      2023.