PMID- 36817455
OWN - NLM
STAT- MEDLINE
DCOM- 20230227
LR  - 20230307
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 14
DP  - 2023
TI  - Biomarkers for early complications post hematopoietic cell transplantation: 
      Insights and challenges.
PG  - 1100306
LID - 10.3389/fimmu.2023.1100306 [doi]
LID - 1100306
AB  - Hematopoietic cell transplantation is an established curative treatment option 
      for various hematological malignant, and non-malignant diseases. However, the 
      success of HCT is still limited by life-threatening early complications post-HCT, 
      such as Graft Versus Host Disease (GVHD), Sinusoidal Obstruction Syndrome (SOS), 
      and transplant-associated microangiopathy, to name a few. A decade of research in 
      the discovery and validation of novel blood-based biomarkers aims to manage these 
      early complications by using them for diagnosis or prognosis. Advances in this 
      field have also led to predictive biomarkers to identify patients' likelihood of 
      response to therapy. Although biomarkers have been extensively evaluated for 
      different complications, these are yet to be used in routine clinical practice. 
      This review provides a detailed summary of various biomarkers for individual 
      early complications post-HCT, their discovery, validation, ongoing clinical 
      trials, and their limitations. Furthermore, this review also provides insights 
      into the biology of biomarkers and the challenge of obtaining a universal cut-off 
      value for biomarkers.
CI  - Copyright (c) 2023 Balakrishnan, Kulkarni, Pai, Illangeswaran, Mohanan, Mathews, 
      George and Balasubramanian.
FAU - Balakrishnan, Balaji
AU  - Balakrishnan B
AD  - Department of Integrative Biology, School of Bio Sciences and Technology, Vellore 
      Institute of Technology, Vellore, India.
FAU - Kulkarni, Uday Prakash
AU  - Kulkarni UP
AD  - Department of Haematology, Christian Medical College, Vellore, India.
FAU - Pai, Aswin Anand
AU  - Pai AA
AD  - Department of Haematology, Christian Medical College, Vellore, India.
FAU - Illangeswaran, Raveen Stephen Stallon
AU  - Illangeswaran RSS
AD  - Department of Haematology, Christian Medical College, Vellore, India.
FAU - Mohanan, Ezhilpavai
AU  - Mohanan E
AD  - Department of Haematology, Christian Medical College, Vellore, India.
FAU - Mathews, Vikram
AU  - Mathews V
AD  - Department of Haematology, Christian Medical College, Vellore, India.
FAU - George, Biju
AU  - George B
AD  - Department of Haematology, Christian Medical College, Vellore, India.
FAU - Balasubramanian, Poonkuzhali
AU  - Balasubramanian P
AD  - Department of Haematology, Christian Medical College, Vellore, India.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230202
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Biomarkers
MH  - *Hematopoietic Stem Cell Transplantation/adverse effects
MH  - *Graft vs Host Disease/etiology
MH  - Prognosis
MH  - *Hepatic Veno-Occlusive Disease
PMC - PMC9932777
OTO - NOTNLM
OT  - GVHD
OT  - HSCT
OT  - SOS
OT  - biomarker
OT  - endothelial
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/02/24 06:00
MHDA- 2023/03/03 06:00
PMCR- 2023/01/01
CRDT- 2023/02/23 09:36
PHST- 2022/11/16 00:00 [received]
PHST- 2023/01/23 00:00 [accepted]
PHST- 2023/02/23 09:36 [entrez]
PHST- 2023/02/24 06:00 [pubmed]
PHST- 2023/03/03 06:00 [medline]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2023.1100306 [doi]
PST - epublish
SO  - Front Immunol. 2023 Feb 2;14:1100306. doi: 10.3389/fimmu.2023.1100306. 
      eCollection 2023.