PMID- 36818372
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230224
IS  - 2090-598X (Print)
IS  - 2090-5998 (Electronic)
IS  - 2090-598X (Linking)
VI  - 21
IP  - 1
DP  - 2023
TI  - Outcome of hyaluronic acid gel injection in glans penis for treatment of lifelong 
      premature ejaculation: A pilot study.
PG  - 31-35
LID - 10.1080/2090598X.2022.2100580 [doi]
AB  - OBJECTIVE: To assess safety and efficacy of hyaluronic acid (HA) gel injection in 
      glans penis for treatment of premature ejaculation (PE) using our new five 
      puncture technique. PATIENTS AND METHODS: This is a prospective, non-randomized 
      clinical trial on HA gel injection in glans penis for all patients with lifelong 
      PE; all patients were circumcised having heterosexual normal marital life and 
      sexually active. Patients with history of ejaculatory medication use within the 
      previous 3 months, psychiatric disorders, erectile dysfunction, lower urinary 
      tract symptoms (LUTS) due to prostatitis and acquired PE were excluded from the 
      study. A local anesthetic was applied to the skin of glans penis for 30 minutes 
      before the injection of 2 ml HA in glans penis via 30-gauge needle using our new 
      Five-puncture technique. Intra-vaginal ejaculatory latency time (IELT) was 
      measured at 1, 3, 6 and 12 months after injection. RESULTS: Thirty patients 
      completed our study follow up schedule. Mean age of the patients was 
      41.72 +/- 8.50, while mean age of female partner was 37.23 +/- 8.54 years. IELT was 
      highly significantly increased (P-value < 0.001) after HA gel injection from 
      baseline, which was in maximum 37.83 +/- 11.01 sec at baseline to 323.03 +/- 42.06, 
      281.07 +/- 41.05, 241.03 +/- 43.09 and 235.6 +/- 41.87 sec after 1, 3, 6 and 12 months, 
      respectively, after injection. Three patients complained from discomfort at the 
      site of injection, two from bullae formation at the site of injection and one 
      from ecchymosis, and all resolved spontaneously after 1 week to 10 days after 
      injection. CONCLUSION: HA gel injection in glans penis using our new 
      five-puncture technique is a safe and effective method that ensures a modest 
      long-term significant increase in IELT and improves ejaculatory control.
CI  - (c) 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & 
      Francis Group.
FAU - Sakr, Ahmed
AU  - Sakr A
AD  - Faculty of Medicine, Urology Department, Zagazig University, Zagazig, Egypt.
FAU - Elgalaly, Hazem
AU  - Elgalaly H
AD  - Faculty of Medicine, Urology Department, Zagazig University, Zagazig, Egypt.
FAU - Seleem, Mohamed M
AU  - Seleem MM
AD  - Faculty of Medicine, Urology Department, Zagazig University, Zagazig, Egypt.
FAU - Kamel, Mostafa
AU  - Kamel M
AD  - Faculty of Medicine, Urology Department, Zagazig University, Zagazig, Egypt.
FAU - El-Sakka, Ahmed I
AU  - El-Sakka AI
AD  - Faculty of Medicine, Urology Department, Suez Canal University, Ismailia, Egypt.
FAU - Ibrahim, Ibrahim M
AU  - Ibrahim IM
AD  - Faculty of Medicine, Urology Department, Zagazig University, Zagazig, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20220719
PL  - United States
TA  - Arab J Urol
JT  - Arab journal of urology
JID - 101562480
PMC - PMC9930752
OTO - NOTNLM
OT  - Glans penis injection
OT  - hyaluronic acid
OT  - premature ejaculation
COIS- No potential conflict of interest was reported by the author(s).
EDAT- 2023/02/24 06:00
MHDA- 2023/02/24 06:01
PMCR- 2022/07/19
CRDT- 2023/02/23 09:49
PHST- 2023/02/23 09:49 [entrez]
PHST- 2023/02/24 06:00 [pubmed]
PHST- 2023/02/24 06:01 [medline]
PHST- 2022/07/19 00:00 [pmc-release]
AID - 2100580 [pii]
AID - 10.1080/2090598X.2022.2100580 [doi]
PST - epublish
SO  - Arab J Urol. 2022 Jul 19;21(1):31-35. doi: 10.1080/2090598X.2022.2100580. 
      eCollection 2023.