PMID- 36818609
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230224
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 11
IP  - 4
DP  - 2023 Feb 6
TI  - Development of Henoch-Schoenlein purpura in a child with idiopathic 
      hypereosinophilia syndrome with multiple thrombotic onset: A case report.
PG  - 952-961
LID - 10.12998/wjcc.v11.i4.952 [doi]
AB  - BACKGROUND: The incidence of pulmonary embolism (PE) in children is low, but its 
      mortality is high. Hypereosinophilic syndrome (HES) is a group of diseases caused 
      by an abnormal increase in eosinophilic granulocytes resulting in multiple-organ 
      dysfunction. The urgent event of thromboembolism in the pulmonary region provoked 
      by eosinophils in idiopathic HES (IHES) is relatively unusual. This article 
      reports a case of IHES with multiple PEs and left leg venous thrombosis as the 
      first manifestation. One month later, the patient developed Henoch-Schonlein 
      purpura (HSP), which is very rare. CASE SUMMARY: We report the case of a 
      12-year-old boy who was admitted to the hospital with dyspnea, left leg pain, and 
      aggravation. He had bilateral PE and left leg venous embolism with mild 
      eosinophilia. Low-molecular-weight heparin and urokinase were given. At the same 
      time, the interventional department was contacted about filter implantation, 
      followed by urokinase thrombolysis. The left leg thrombus was aspirated under 
      ultrasound guidance. He was discharged from the hospital on rivaroxaban. One 
      month later, he developed a rash on both legs and ankle pain consistent with HSP, 
      with severe eosinophilia and motor and sensory disturbances. The patient was 
      diagnosed with IHES with multiple embolisms complicated by HSP after excluding 
      other causes of the eosinophil elevation. After glucocorticoid treatment, the 
      symptoms were relieved, but the patient later developed purpura nephritis. 
      CONCLUSION: We report a rare and life-threatening case of IHES with multiple 
      embolisms associated with HSP. A mild elevation of eosinophils early in the 
      disease leads to difficulties in diagnosis and delayed treatment.
CI  - (c)The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Xu, Yan-Yan
AU  - Xu YY
AD  - Department of Pediatric Cardiovascular, Anhui Province Children's Hospital, Anhui 
      Hospital of Children's Hospital Affiliated with Fudan University, Hefei 230051, 
      Anhui Province, China.
FAU - Huang, Xiao-Bi
AU  - Huang XB
AD  - Department of Pediatric Cardiovascular, Anhui Province Children's Hospital, Anhui 
      Hospital of Children's Hospital Affiliated with Fudan University, Hefei 230051, 
      Anhui Province, China.
FAU - Wang, Yun-Gong
AU  - Wang YG
AD  - Department of Pediatric Cardiovascular, Anhui Province Children's Hospital, Anhui 
      Hospital of Children's Hospital Affiliated with Fudan University, Hefei 230051, 
      Anhui Province, China.
FAU - Zheng, Li-Yun
AU  - Zheng LY
AD  - Department of Pediatric Cardiovascular, Anhui Province Children's Hospital, Anhui 
      Hospital of Children's Hospital Affiliated with Fudan University, Hefei 230051, 
      Anhui Province, China.
FAU - Li, Min
AU  - Li M
AD  - Department of Pediatric Intensive Care Unit, Anhui Province Children's Hospital, 
      Anhui Hospital of Children's Hospital affiliated with Fudan University, Hefei 
      230051, Anhui Province, China.
FAU - Dai, Yu
AU  - Dai Y
AD  - Department of Pediatrics, The Fourth Affiliated Hospital of Anhui Medical 
      University, Hefei 230032, Anhui Province, China.
FAU - Zhao, Sheng
AU  - Zhao S
AD  - Department of Pediatric Cardiovascular, Anhui Province Children's Hospital, Anhui 
      Hospital of Children's Hospital Affiliated with Fudan University, Hefei 230051, 
      Anhui Province, China. 382877830@qq.com.
LA  - eng
PT  - Case Reports
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC9928698
OTO - NOTNLM
OT  - Case report
OT  - Eosinophil
OT  - Henoch-Schoenlein purpura
OT  - Hypereosinophilic syndrome
OT  - Thrombosis
COIS- Conflict-of-interest statement: The authors declare that they have no conflict of 
      interest to disclose.
EDAT- 2023/02/24 06:00
MHDA- 2023/02/24 06:01
PMCR- 2023/02/06
CRDT- 2023/02/23 09:54
PHST- 2022/11/16 00:00 [received]
PHST- 2022/12/11 00:00 [revised]
PHST- 2023/01/09 00:00 [accepted]
PHST- 2023/02/23 09:54 [entrez]
PHST- 2023/02/24 06:00 [pubmed]
PHST- 2023/02/24 06:01 [medline]
PHST- 2023/02/06 00:00 [pmc-release]
AID - 10.12998/wjcc.v11.i4.952 [doi]
PST - ppublish
SO  - World J Clin Cases. 2023 Feb 6;11(4):952-961. doi: 10.12998/wjcc.v11.i4.952.